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公开(公告)号:US5646121A
公开(公告)日:1997-07-08
申请号:US302064
申请日:1994-09-07
申请人: Dieter Habich , Thomas-J. Schulze , Jurgen Reefschlager , Jutta Hansen , Rainer Neumann , Gert Streissle , Arnold Paessens
发明人: Dieter Habich , Thomas-J. Schulze , Jurgen Reefschlager , Jutta Hansen , Rainer Neumann , Gert Streissle , Arnold Paessens
IPC分类号: C07D249/06 , A61K38/00 , A61P31/12 , C07C237/22 , C07C271/10 , C07C275/28 , C07C279/02 , C07C279/14 , C07C311/64 , C07C317/44 , C07D213/24 , C07D213/81 , C07D215/48 , C07D311/70 , C07D333/70 , C07K1/02 , C07K1/10 , C07K1/113 , C07K1/12 , C07K5/068 , C07K5/072 , C07K5/087 , C07K5/09 , C07K5/093 , C07K5/097 , C07D241/04 , A61K31/16 , A61K31/165 , C07D211/06
CPC分类号: C07K5/0817 , C07C311/64 , C07K5/06095 , A61K38/00
摘要: The present invention relates to novel pseudopeptides with antiviral activity of the general formula (I) ##STR1## in which the substituents have the meaning given in the description, to a process for their preparation, and to their use as antiviral agents, especially against cytomegaloviruses.
摘要翻译: 本发明涉及具有通式(I)(I)的抗病毒活性的新型伪肽,其中取代基具有本说明书中给出的含义,其制备方法及其作为抗病毒剂的用途, 特别是针对巨细胞病毒。
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公开(公告)号:US07220824B1
公开(公告)日:2007-05-22
申请号:US10070208
申请日:2000-08-28
申请人: Hans-Georg Lerchen , Jörg Baumgarten , Ulf Brüggemeier , Markus Albers , Andreas Schoop , Thomas-J. Schulze
发明人: Hans-Georg Lerchen , Jörg Baumgarten , Ulf Brüggemeier , Markus Albers , Andreas Schoop , Thomas-J. Schulze
IPC分类号: A61K38/14
CPC分类号: C07D491/22
摘要: The present invention relates to cytostatics which have a tumour-specific action as a result of linkage to αvβ3 integrin antagonists via preferred linking units. The preferred linking units guarantee serum stability of the conjugate of cytostatic and αvβ3 integrin antagonist and at the same time the desired intracellular action in tumour cells as a result of their enzymatic or hydrolytic cleavability with release of the cytostatic.
摘要翻译: 本发明涉及通过优选连接单元与α-β3整联蛋白拮抗剂连接而具有肿瘤特异性作用的细胞抑制剂。 优选的连接单元保证细胞生长抑制和α3β3整联蛋白拮抗剂的缀合物的血清稳定性,同时由于它们的结合,肿瘤细胞中期望的细胞内作用 酶促或水解裂解性,释放细胞抑制作用。
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