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公开(公告)号：US20060035229A1
公开(公告)日：2006-02-16
申请号：US10519988
申请日：2003-07-04
申请人： Dieter Scharnweber , Rene Beutner , Sophie Roessler , Thomas Hanke , Hartmut Worch , Bernd Schwenzer , Jan Michael
发明人： Dieter Scharnweber , Rene Beutner , Sophie Roessler , Thomas Hanke , Hartmut Worch , Bernd Schwenzer , Jan Michael
CPC分类号： A61K9/0024 , A61K9/1611 , A61K9/167 , A61L27/306 , B01J2219/00527 , B01J2219/00574 , B01J2219/00576 , B01J2219/00641 , B01J2219/00722 , C25D11/02 , C40B40/06
摘要： A metallic object has a coating made of a thin metal oxide layer and nucleic acids or nucleic acid derivatives bonded thereto. The nucleic acid compounds have 5′-terminal or 3′-terminal molecule areas that are incorporated stably into the metal oxide layer. The unincorporated areas of the nucleic acid compounds that are not incorporated into the metal oxide layer are freely accessible for subsequent interactions with other molecules such as complementary nucleic acids having active ingredients attached thereto.
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2.发明申请公开(公告)号：US20050079198A1
公开(公告)日：2005-04-14
申请号：US10918743
申请日：2004-08-16
CPC分类号： C25D9/02 , A61L27/34 , A61L27/54 , A61L2300/232 , A61L2300/236 , A61L2300/252 , A61L2300/406 , A61L2300/426 , A61L2300/606 , C08L5/08
摘要： The invention describes an article made from chitosan-coated metal, where an impermeable chitosan layer having a barrier action is present on the metal through electrochemical polarisation in a chitosan-containing solution. The incorporation of biologically active components into the chitosan coating enables the coating to be matched to various applications and the bio-compatibility of correspondingly modified surfaces to be increased. Metallic articles or surfaces coated in this way are used, for example, as material for medical implants.
摘要翻译： 本发明描述了由壳聚糖涂覆的金属制成的制品，其中通过在含壳聚糖的溶液中的电化学极化，在金属上存在具有屏障作用的不可渗透的壳聚糖层。 将生物活性成分并入壳聚糖涂层中使得涂层能够匹配各种应用，并且相应改性表面的生物相容性增加。 以这种方式涂覆的金属制品或表面例如用作医疗植入物的材料。
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