公开(公告)号：US6121300A

公开(公告)日：2000-09-19

申请号：US189200

申请日：1998-11-10

申请人： Dilip R. Wagle ,  Sheng-Ding Fang ,  Taikyun Rho ,  John J. Egan ,  Sara Vasan ,  Peter Ulrich ,  Anthony Cerami

发明人： Dilip R. Wagle ,  Sheng-Ding Fang ,  Taikyun Rho ,  John J. Egan ,  Sara Vasan ,  Peter Ulrich ,  Anthony Cerami

IPC分类号： C07D277/20 ,  A61K8/00 ,  A61K8/49 ,  A61K31/426 ,  A61K31/427 ,  A61K31/431 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61P9/14 ,  A61P13/12 ,  A61P17/00 ,  A61P27/02 ,  A61Q19/00 ,  C07D277/22 ,  C07D277/24 ,  C07D277/44 ,  C07D417/06

CPC分类号： C07D277/22 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5355 ,  A61K31/541 ,  A61K31/55 ,  C07D277/44 ,  C07D417/06

摘要： The present invention relates to compositions and methods for reversing advanced glycosylation end product-mediated cross-linking and protein aging. Accordingly, compositions are described which comprise thiazolium compounds substituted with heterocyclic groups which are capable of reversing the formation of advanced glycosylation end product cross-links. Both industrial and therapeutic applications for the invention are disclosed, as food spoilage and animal protein aging can be treated. Such compounds have particular application in the treatment of protein aging such as is responsible for the complications of aging and diabetes.

公开(公告)号：US06319934B1

公开(公告)日：2001-11-20

申请号：US09644024

申请日：2000-08-23

申请人： Dilip R. Wagle ,  Sheng-Ding Fang ,  Taikyun Rho ,  John J. Egan ,  Sara Vasan ,  Peter Ulrich ,  Anthony Cerami

发明人： Dilip R. Wagle ,  Sheng-Ding Fang ,  Taikyun Rho ,  John J. Egan ,  Sara Vasan ,  Peter Ulrich ,  Anthony Cerami

IPC分类号： C07D27724

CPC分类号： C07D277/22 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5355 ,  A61K31/541 ,  A61K31/55 ,  C07D277/44 ,  C07D417/06

摘要： The present invention relates to compositions and methods for reversing advanced glycosylation end product-mediated cross-linking and protein aging. Accordingly, compositions are described which comprise thiazolium compounds substituted with heterocyclic groups which are capable of reversing the formation of advanced glycosylation end product cross-links. Both industrial and therapeutic applications for the invention are disclosed, as food spoilage and animal protein aging can be treated. Such compounds have particular application in the treatment of protein aging such as is responsible for the complications of aging and diabetes.

摘要翻译： 本发明涉及用于逆转晚期糖基化终产物介导的交联和蛋白质老化的组合物和方法。 因此，描述了包含被能够逆转高级糖基化终产物交联的形成的杂环基取代的噻唑鎓化合物的组合物。 公开了用于本发明的工业和治疗应用，因为可以处理食物腐败和动物蛋白质老化。 这些化合物在治疗老化和糖尿病并发症等蛋白质老化中具有特殊的应用。

公开(公告)号：US06790859B2

公开(公告)日：2004-09-14

申请号：US10348378

申请日：2003-01-21

申请人： Dilip R. Wagle ,  Sheng-Ding Fang ,  Taikyun Rho ,  John J. Egan ,  Sara Vasan ,  Peter Ulrich ,  Anthony Cerami

发明人： Dilip R. Wagle ,  Sheng-Ding Fang ,  Taikyun Rho ,  John J. Egan ,  Sara Vasan ,  Peter Ulrich ,  Anthony Cerami

IPC分类号： A61K31425

CPC分类号： C07D277/22 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5355 ,  A61K31/541 ,  A61K31/55 ,  C07D277/44 ,  C07D417/06

摘要： The present invention relates to compositions and methods for reversing advanced glycosylation end product-mediated cross-linking and protein aging. Accordingly, compositions are described which comprise thiazolium compounds substituted with heterocyclic groups which are capable of reversing the formation of advanced glycosylation end product cross-links. Both industrial and therapeutic applications for the invention are disclosed, as food spoilage and animal protein aging can be treated. Such compounds have particular application in the treatment of protein aging such as is responsible for the complications of aging and diabetes.

摘要翻译： 本发明涉及用于逆转晚期糖基化终产物介导的交联和蛋白质老化的组合物和方法。 因此，描述了包含被能够逆转高级糖基化终产物交联的形成的杂环基取代的噻唑鎓化合物的组合物。 公开了用于本发明的工业和治疗应用，因为可以处理食物腐败和动物蛋白质老化。 这些化合物在治疗老化和糖尿病并发症等蛋白质老化中具有特殊的应用。

公开(公告)号：US5869527A

公开(公告)日：1999-02-09

申请号：US771958

申请日：1996-12-23

申请人： Sheng-Ding Fang ,  Michael E. Lankin ,  Henry W. Founds ,  David H. Shih

发明人： Sheng-Ding Fang ,  Michael E. Lankin ,  Henry W. Founds ,  David H. Shih

IPC分类号： A61K31/197 ,  A61K31/235

CPC分类号： G01N33/6842 ,  A61K31/197

摘要： Compounds useful in the production and analysis of monoclonal antibodies to advanced glycosylation endproducts are 6-(N-carboxymethylamino)caproates of the formulaXO.sub.2 C--(CH.sub.2).sub.5 --NH--CH.sub.2 CO.sub.2 X (I)wherein X is hydrogen or an alkali metal salt cation. These compounds can be used in the production of such monoclonal antibodies, and to assess the purity and reactivity of AGE-antibodies produced for diagnostic purposes.

摘要翻译： 用于生产和分析晚期糖基化终产物的单克隆抗体的化合物是式XO2C-（CH2）5-NH-CH2CO2X（I）的6-（N-羧甲基氨基）己酸盐，其中X是氢或碱金属盐阳离子。 这些化合物可以用于生产这样的单克隆抗体，并且用于评估为诊断目的而生产的AGE-抗体的纯度和反应性。