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    Biomarkers and assays for Alzheimer's disease
    7.
    发明申请
    Biomarkers and assays for Alzheimer's disease 审中-公开
    阿尔茨海默病的生物标记物和测定法

    公开(公告)号：US20080220449A1

    公开(公告)日：2008-09-11

    申请号：US12069399

    申请日：2008-02-08

    申请人： Sara Vasan ,  Eliot J. Davidowitz ,  James G. Moe

    发明人： Sara Vasan ,  Eliot J. Davidowitz ,  James G. Moe

    IPC分类号： G01N33/53 ,  G01N33/00 ,  C07K16/18 ,  G01N33/566

    CPC分类号： C07K16/18 ,  G01N33/6896 ,  G01N2800/2821 ,  G01N2800/56

    摘要： Methods, compositions and systems are provided for diagnosing, stratifying, or monitoring the progression or regression of Alzheimer's disease (AD), the methods, compositions and systems comprise detecting in a sample a level of at least one AD biomarker, the AD biomarker comprising at least phosphorylated tau pT217, soluble tau oligomer, tau-amyloid-beta 1-42 complex, a fragment thereof or a combination thereof and comparing the level from the sample to a reference level of phosphorylated tau pT217, soluble tau oligomer, and/or tau-amyloid-beta 1-42 complex to diagnose or stratify or monitor the progression or regression of AD. In various embodiments, diagnostic assay and screening kits are provided. In various embodiments, the assay and kits provided can monitor the therapeutic effect of a drug and/or AD treatment. In various embodiments, the assay can be used to screen for drugs that disrupt the AD biomarker(s)

    摘要翻译： 提供了用于诊断，分层或监测阿尔茨海默病（AD）的进展或消退的方法，组合物和系统，所述方法，组合物和系统包括在样品中检测至少一种AD生物标志物的水平，所述AD生物标志物包含 最小磷酸化tau pT217，可溶性tau低聚物，tau-淀粉样蛋白-β1-42复合物，其片段或其组合，并将来自样品的水平与磷酸化tau pT217，可溶性tau低聚物和/或tau的参考水平进行比较 - 淀粉样蛋白-β1-42复合物来诊断或分层或监测AD的进展或消退。 在各种实施方案中，提供诊断测定和筛选试剂盒。 在各种实施方案中，提供的测定和试剂盒可以监测药物和/或AD治疗的治疗效果。 在各种实施方案中，该测定可用于筛选破坏AD生物标志物的药物，

    Agglomeration protein cascades, compositions and methods regarding the same
    9.
    发明申请
    Agglomeration protein cascades, compositions and methods regarding the same 审中-公开
    聚集蛋白级联，组合物和方法相同

    公开(公告)号：US20060257904A1

    公开(公告)日：2006-11-16

    申请号：US11400808

    申请日：2006-04-07

    申请人： Abraham Grossman ,  James Moe ,  Sara Vasan ,  Eliot Davidowitz

    发明人： Abraham Grossman ,  James Moe ,  Sara Vasan ,  Eliot Davidowitz

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12M1/34

    CPC分类号： C07K14/78 ,  C07K14/4711 ,  C07K2319/00 ,  C12N15/115 ,  C12N2310/16 ,  G01N2333/4709 ,  G01N2333/78 ,  G01N2800/2821

    摘要： Described herein are compositions and methods for identifying cellular factors involved in protein agglomeration. One such factor is a nucleic acid component. Another factor is a cellular binding factor. The nucleic acid components, and methods of using them, to interact with agglomeration proteins are also disclosed herein. The nucleic acid compositions herein comprise one or more DNA or RNA molecules having affinity for at least one agglomeration protein. The nucleic acid component is a naturally or non-naturally occurring molecule with twenty or more ribonucleotide bases. For RNA, at least one nucleotide sequence portion of this RNA molecule has affinity to at least one consensus sequence present in the agglomeration RNA-binding protein. Methods disclosed herein are directed towards detecting the presence of one or more agglomeration proteins in a sample matrix using the amplibody compositions described herein. Also described herein is an in vitro system (“TRIPARTITE”), which utilizes a NA and a non-NA chaperone to analyze the amyloid disease progression and test drugs potentially useful in combating such diseases. Also described are in vivo, transgenic animal models for analyzing amyloid diseases and agents potentially useful in combating those diseases.

    摘要翻译： 本文描述了用于鉴定涉及蛋白质聚集的细胞因子的组合物和方法。 一个这样的因素是核酸组分。 另一个因素是细胞结合因子。 本文还公开了核酸组分及其使用方法与附聚蛋白相互作用。 本文的核酸组合物包含一种或多种对至少一种附聚蛋白具有亲和力的DNA或RNA分子。 核酸组分是具有二十个以上核糖核苷酸碱基的天然或非天然存在的分子。 对于RNA，该RNA分子的至少一个核苷酸序列部分对结合RNA结合蛋白中存在的至少一个共有序列具有亲和力。 本文公开的方法旨在使用本文所述的扩增体组合物来检测样品基质中一种或多种附聚蛋白的存在。 本文还描述了一种体外系统（“TRIPARTITE”），其利用NA和非NA伴侣来分析淀粉样蛋白病进展并测试潜在地有助于抵抗此类疾病的药物。 还描述了用于分析淀粉样蛋白病的体内转基因动物模型和可能用于对抗这些疾病的药剂。