公开(公告)号：US20070134684A1

公开(公告)日：2007-06-14

申请号：US11457713

申请日：2006-07-14

申请人： Dmitri Petrovykh ,  Lloyd Whitman ,  Michael Tarlov ,  Aric Opdahl ,  Hiromi Kimura-Suda

发明人： Dmitri Petrovykh ,  Lloyd Whitman ,  Michael Tarlov ,  Aric Opdahl ,  Hiromi Kimura-Suda

IPC分类号： C12Q1/68 ,  C12M1/34 ,  B05D3/00

CPC分类号： B01J19/0046 ,  B01J2219/00529 ,  B01J2219/00572 ,  B01J2219/00596 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00734 ,  B01J2219/0074 ,  B01J2219/00743

摘要： The method provides for attaching nucleic acids to a surface at a controlled grafting density in a controlled conformation by contacting an immobilization solution of nucleic acids containing at least one block of adenine nucleotides to a surface for a sufficient period of time to allow attachment to the surface. Another aspect of the methods described provides for controlling the grafting density of immobilized oligonucleotides by coadsorption/displacement by oligo(dA). Another aspect provides for a method of immobilizing oligonucleotides in complex conformations by varying the number and position of the block(s) of adenine nucleotides in the sequence of said oligonucleotides. Another aspect provides for controlled immobilization of a functional unit, such as a ligand, a molecule, a macromolecule, an aptamer, a lectin, an immunoglobulin, an antibody, a biomolecule, a solid state particle, a vesicle, or a label to a surface via attachment to at least one block of adenine nucleotides.

摘要翻译： 该方法提供以受控构象的受控接枝密度将核酸附着到表面，通过将含有至少一个腺嘌呤核苷酸嵌段的核酸的固定化溶液与表面接触足够的时间以允许附着于表面 。 所述方法的另一方面提供了通过寡聚（dA）的共吸附/置换来控制固定的寡核苷酸的接枝密度。 另一方面提供了通过改变所述寡核苷酸序列中腺嘌呤核苷酸嵌段的数目和位置来固定复合构象中的寡核苷酸的方法。 另一方面提供功能单元如配体，分子，大分子，适体，凝集素，免疫球蛋白，抗体，生物分子，固态颗粒，囊泡或标签的受控固定化 通过连接至至少一个腺嘌呤核苷酸区的表面。

公开(公告)号：US06538744B1

公开(公告)日：2003-03-25

申请号：US09666410

申请日：2000-09-20

申请人： Hiromi Kimura-Suda ,  Takafumi Sassa ,  Tatsuo Wada ,  Hiroyuki Sasabe

发明人： Hiromi Kimura-Suda ,  Takafumi Sassa ,  Tatsuo Wada ,  Hiroyuki Sasabe

IPC分类号： G01B902

CPC分类号： G01J4/04

摘要： According to the present invention, it is adapted to calculate simultaneously an absolute molecular orientation with an effective second order nonlinear optical constant in an object to be measured without changing a measuring point. Further, in order that a period of time required for measuring an absolute molecular orientation and an effective second order nonlinear optical constant in an object to be measured is reduced, whereby a possibility of damaging the object to be measured can be minimized, measurement is carried out by the use of a single light source in accordance with SHG phase method without shifting the measuring point of the; object to be measured, so that the absolute molecular orientation and the effective second order nonlinear optical constant can be calculated from a fitting curve achieved as a result of fitting the fringe obtained by the above described measurement.

摘要翻译： 根据本发明，适于在不改变测量点的情况下同时计算待测物体中的有效二阶非线性光学常数的绝对分子取向。 此外，为了减少测量对象物中的绝对分子取向和有效的二阶非线性光学常数所需的时间，可以使被测定物的损害的可能性最小化，进行测量 通过使用单个光源根据SHG相位法不移动测量点; 可以从通过上述测量得到的边缘拟合的结果所得到的拟合曲线计算绝对分子取向和有效二阶非线性光学常数。

公开(公告)号：US06414089B1

公开(公告)日：2002-07-02

申请号：US09650296

申请日：2000-08-29

申请人： Hiromi Kimura-Suda ,  Hiroyuki Sasabe ,  Tatsuo Wada

发明人： Hiromi Kimura-Suda ,  Hiroyuki Sasabe ,  Tatsuo Wada

IPC分类号： C08L2500

CPC分类号： B82Y20/00 ,  C08G61/12 ,  G02F1/361 ,  G02F1/3615 ,  G02F1/3616 ,  G02F1/3617 ,  G02F2001/3509 ,  Y10T428/10 ,  Y10T428/31504 ,  Y10T428/31507 ,  Y10T428/31544 ,  Y10T428/31616 ,  Y10T428/31721 ,  Y10T428/31743 ,  Y10T428/31786 ,  Y10T428/31797 ,  Y10T428/31855

摘要： A method of manufacturing a polymer film having second order non-linear optical properties which has excellent stability of orientated molecules and does not become disorientated, and a polymer film and a non-linear optical element are provided. A polymer solution is placed between two substrates, which are disposed substantially perpendicular with respect to a rotating stand and substantially symmetrical with respect to a rotation axis of the rotating stand, and the rotating stand is rotated. A polymer film having second order non-linear optical properties is formed by the centrifugal force generated at the polymer solution. The polymer solution is a solution formed by dissolving, in an organic solvent, at least one of (1) a host-guest polymer in which low molecular weight compounds are dispersed in polymers, (2) a modified polymer in which regions which exhibit a function of second order non-linear optical properties are chemically modified in polymer side chains and/or a polymer main chain, and (3) a crosslinked polymer. Among these, modified polymers are particularly preferable.

摘要翻译： 提供具有优异的取向分子的稳定性并且不会变得无定向的具有二次非线性光学性质的聚合物膜的制造方法，以及聚合物膜和非线性光学元件。 将聚合物溶液放置在两个基板之间，这两个基板相对于旋转支架基本上垂直设置并且相对于旋转支架的旋转轴线基本上对称，并且旋转支架旋转。 通过聚合物溶液产生的离心力形成具有二次非线性光学特性的聚合物膜。 聚合物溶液是通过在有机溶剂中溶解（1）将低分子量化合物分散在聚合物中的主体 - 客体聚合物中的至少一种而形成的溶液，（2）改性聚合物，其中表现出 二阶非线性光学性质的功能在聚合物侧链和/或聚合物主链中被化学改性，和（3）交联聚合物。 其中特别优选改性聚合物。