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1.发明申请6-ALKENYL AND 6-PHENYLALKYL SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE) POLYMERASE INHIBITORS 有权6-烷基和6-苯基取代的2-喹啉酮和2-喹啉酮作为聚（ADP-赖酮）聚合酶抑制剂公开(公告)号：US20110124673A1
公开(公告)日：2011-05-26
申请号：US12950345
申请日：2010-11-19
申请人： Dominique Jean-Pierre Mabire , Jerôme Emile Georges Guillemont , Jacobus Alphonsus Josephus Van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
发明人： Dominique Jean-Pierre Mabire , Jerôme Emile Georges Guillemont , Jacobus Alphonsus Josephus Van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
IPC分类号： A61K31/473 , C07D405/14 , C07D401/12 , C07D221/12 , A61P35/00 , A61P25/00 , A61P25/28 , A61P25/02 , A61P29/00 , A61P19/02 , A61P3/10 , A61P9/10
CPC分类号： C07D215/227 , C07D241/44 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/12
摘要： The present invention provides compounds of formula (I) and compounds of formula (VII-a) as well as pharmaceutical compositions comprising said compounds and their use as PARP inhibitors wherein n, R1, R2, R3, R4, R5, R6, R7, Re, Rd and X have defined meanings.
摘要翻译： 本发明提供式（I）化合物和式（VII-a）化合物以及包含所述化合物及其用作PARP抑制剂的药物组合物，其中n，R1，R2，R3，R4，R5，R6，R7， Re，Rd和X定义含义。
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2.发明授权6-substituted 2-quinolinones and 2-quinoxalinones as poly (adp-ribose) polymerase inhibitors 有权6-取代的2-喹啉酮和2-喹喔啉酮作为聚（adp-核糖）聚合酶抑制剂公开(公告)号：US07879857B2
公开(公告)日：2011-02-01
申请号：US10596086
申请日：2004-11-18
申请人： Dominique Jean-Pierre Mabire , Jérôme Emile Georges Guillemont , Jacobus Alphonsus Josephus Van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
发明人： Dominique Jean-Pierre Mabire , Jérôme Emile Georges Guillemont , Jacobus Alphonsus Josephus Van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
IPC分类号： C07D241/44 , C07D215/227 , A61K31/498 , A61K31/4704 , A61P25/28
CPC分类号： C04B35/632 , C07D241/44 , C07D401/12 , C07D407/06 , C07D409/14
摘要： The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, R1, R2, R3, R4 and X have defined meanings.
摘要翻译： 本发明提供式（I）化合物，它们作为PARP抑制剂的用途以及包含所述式（I）化合物的药物组合物，其中n，R1，R2，R3，R4和X具有定义的含义。
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3.发明授权7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors 有权作为聚（ADP-核糖）聚合酶抑制剂的7-苯基烷基取代的2-喹啉酮和2-喹喔啉酮公开(公告)号：US08524714B2
公开(公告)日：2013-09-03
申请号：US13047402
申请日：2011-03-14
申请人： Dominique Jean-Pierre Mabire , Jerome Emile Georges Guillemont , Jacobus Alphonsus Josephus van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
发明人： Dominique Jean-Pierre Mabire , Jerome Emile Georges Guillemont , Jacobus Alphonsus Josephus van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
IPC分类号： A61K31/498 , C07D401/06
CPC分类号： C07D403/06 , C07D241/44 , C07D401/06
摘要： The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, R1, R2, R3, R4, R5, R6 and X have defined meanings.
摘要翻译： 本发明提供式（I）化合物，其作为PARP抑制剂的用途以及包含所述式（I）化合物的药物组合物，其中n，R1，R2，R3，R4，R5，R6和X具有定义的含义。
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公开(公告)号：US08450486B2
公开(公告)日：2013-05-28
申请号：US13284110
申请日：2011-10-28
申请人： Dominique Jean-Pierre Mabire , Jérôme Emile Georges Guillemont , Jacobus Alphonsus Josephus Van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
发明人： Dominique Jean-Pierre Mabire , Jérôme Emile Georges Guillemont , Jacobus Alphonsus Josephus Van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
IPC分类号： A61K31/498
CPC分类号： C07D215/227 , C07D241/44 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/12
摘要： The present invention provides compounds of formula (I) and compounds of formula (VII-a) as well as pharmaceutical compositions comprising said compounds and their use as PARP inhibitors wherein n, R1, R2, R3, R4, R5, R6, R7, Re, Rd and X have defined meanings.
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5.发明授权6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors 有权6-烯基和6-苯基烷基取代的2-喹啉酮和2-喹喔啉酮作为聚（ADP-核糖）聚合酶抑制剂公开(公告)号：US08071612B2
公开(公告)日：2011-12-06
申请号：US12950345
申请日：2010-11-19
申请人： Dominique Jean-Pierre Mabire , Jérôme Emile Georges Guillemont , Jacobus Alphonsus Josephus Van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
发明人： Dominique Jean-Pierre Mabire , Jérôme Emile Georges Guillemont , Jacobus Alphonsus Josephus Van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
IPC分类号： C07D221/12
CPC分类号： C07D215/227 , C07D241/44 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/12
摘要： The present invention provides compounds of formula (I) and compounds of formula (VII-a) as well as pharmaceutical compositions comprising said compounds and their use as PARP inhibitors wherein n, R1, R2, R3, R4, R5, R6, R7, Re, Rd and X have defined meanings.
摘要翻译： 本发明提供式（I）化合物和式（VII-a）化合物以及包含所述化合物及其用作PARP抑制剂的药物组合物，其中n，R1，R2，R3，R4，R5，R6，R7， Re，Rd和X定义含义。
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6.发明申请7-PHENYLALKYL SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE) POLYMERASE INHIBITORS 有权作为聚（ADP-RIBOSE）聚合酶抑制剂的7-苯乙烯取代的2-喹啉酮和2-喹啉酮公开(公告)号：US20110230492A1
公开(公告)日：2011-09-22
申请号：US13047402
申请日：2011-03-14
申请人： Dominique Jean-Pierre Mabire , Jerome Emile Georges Guillemont , Jacobus Alphonsus Josephus van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
发明人： Dominique Jean-Pierre Mabire , Jerome Emile Georges Guillemont , Jacobus Alphonsus Josephus van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
IPC分类号： A61K31/498 , A61K31/4704 , A61P35/00
CPC分类号： C07D403/06 , C07D241/44 , C07D401/06
摘要： The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, R1, R2, R3, R4, R5, R6 and X have defined meanings.
摘要翻译： 本发明提供式（I）化合物，其作为PARP抑制剂的用途以及包含所述式（I）化合物的药物组合物，其中n，R1，R2，R3，R4，R5，R6和X具有定义的含义。
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7.发明申请6-SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE) POLYMERASE INHIBITORS 审中-公开6-取代的2-喹啉酮和2-喹啉酮作为聚（ADP-糖基）聚合酶抑制剂公开(公告)号：US20110230491A1
公开(公告)日：2011-09-22
申请号：US12971319
申请日：2010-12-17
申请人： Dominique Jean-Pierre Mabire , Jerome Emile Georges Guillemont , Jacobus Alphonsus Josephus van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
发明人： Dominique Jean-Pierre Mabire , Jerome Emile Georges Guillemont , Jacobus Alphonsus Josephus van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
IPC分类号： A61K31/498 , C07D241/44 , C07D215/227 , A61K31/4709 , A61P35/00
CPC分类号： C04B35/632 , C07D241/44 , C07D401/12 , C07D407/06 , C07D409/14
摘要： The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, R1, R2, R3, R4 and X have defined meanings.
摘要翻译： 本发明提供式（I）化合物，它们作为PARP抑制剂的用途以及包含所述式（I）化合物的药物组合物，其中n，R1，R2，R3，R4和X具有定义的含义。
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8.发明申请SUBSTITUTED 6-CYCLOHEXYLALKYL SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE) POLYMERASE INHIBITORS 有权取代的6-环戊基二甲基取代的2-喹啉酮和作为聚（ADP-赖酮）聚合酶抑制剂的2-喹喔啉酮公开(公告)号：US20090042881A1
公开(公告)日：2009-02-12
申请号：US10596083
申请日：2004-11-18
申请人： Dominique Jean-Pierre Mabire , Jacobus Alphonsus Josephus Van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
发明人： Dominique Jean-Pierre Mabire , Jacobus Alphonsus Josephus Van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
IPC分类号： A61K31/4709 , C07D401/10 , C07D491/107 , C07D215/227 , C07D413/10 , A61K31/5377 , A61K31/498 , A61K31/496
CPC分类号： C07D241/44 , C07D215/227 , C07D401/06 , C07D401/14 , C07D409/14 , C07D491/10
摘要： The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, s, R1, R2, R3, Q, X and Y have defined meanings.
摘要翻译： 本发明提供式（I）化合物，它们作为PARP抑制剂的用途以及包含所述式（I）化合物的药物组合物，其中n，s，R 1，R 2，R 3，Q，X和Y具有定义的含义。
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9.发明申请6-ALKENYL AND 6-PHENYLALKYL SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE) POLYMERASE INHIBITORS 有权6-烷基和6-苯基取代的2-喹啉酮和2-喹啉酮作为聚（ADP-赖酮）聚合酶抑制剂公开(公告)号：US20120046274A1
公开(公告)日：2012-02-23
申请号：US13284110
申请日：2011-10-28
申请人： Dominique Jean-Pierre Mabire , Jerome Emile Georges Guillemont , Jacobus Alphonsus Josephus Van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
发明人： Dominique Jean-Pierre Mabire , Jerome Emile Georges Guillemont , Jacobus Alphonsus Josephus Van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
IPC分类号： A61K31/4704 , A61K31/496 , A61K31/55 , A61K31/498 , A61P9/10 , A61P37/00 , A61P25/28 , A61P19/02 , A61P19/10 , A61P21/00 , A61P27/02 , A61K31/473 , A61Q19/08
CPC分类号： C07D215/227 , C07D241/44 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/12
摘要： The present invention provides compounds of formula (I) and compounds of formula (VII-a) as well as pharmaceutical compositions comprising said compounds and their use as PARP inhibitors wherein n, R1, R2, R3, R4, R5, R6, R7, Re, Rd and X have defined meanings.
摘要翻译： 本发明提供式（I）化合物和式（VII-a）化合物以及包含所述化合物及其用作PARP抑制剂的药物组合物，其中n，R1，R2，R3，R4，R5，R6，R7， Re，Rd和X定义含义。
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10.发明授权Substituted 6-cyclohexylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors 有权取代的6-环己基烷基取代的2-喹啉酮和2-喹喔啉酮作为聚（ADP-核糖）聚合酶抑制剂公开(公告)号：US07652014B2
公开(公告)日：2010-01-26
申请号：US10596083
申请日：2004-11-18
申请人： Dominique Jean-Pierre Mabire , Jacobus Alphonsus Josephus Van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
发明人： Dominique Jean-Pierre Mabire , Jacobus Alphonsus Josephus Van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
IPC分类号： A61K31/472 , A61K31/498 , A61K31/4709 , C07D241/44 , C07D215/227 , C07D401/06
CPC分类号： C07D241/44 , C07D215/227 , C07D401/06 , C07D401/14 , C07D409/14 , C07D491/10
摘要： The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, s, R1, R2, R3, Q, X and Y have defined meanings.
摘要翻译： 本发明提供式（I）化合物，它们作为PARP抑制剂的用途以及包含所述式（I）化合物的药物组合物，其中n，s，R 1，R 2，R 3，Q，X和Y具有定义的含义。
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