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    METHODS AND USES FOR EX VIVO TISSUE CULTURE SYSTEMS
    1.
    发明申请
    METHODS AND USES FOR EX VIVO TISSUE CULTURE SYSTEMS 有权
    方法和用于EX VIVO组织文化系统

    公开(公告)号：US20140186414A1

    公开(公告)日：2014-07-03

    申请号：US14122273

    申请日：2012-05-31

    申请人： Donald E. Ingber ,  Yusuke Torisawa ,  Geraldine Hamilton ,  Akiko Mammoto ,  Tadanori Mammoto ,  Catherine Spina

    发明人： Donald E. Ingber ,  Yusuke Torisawa ,  Geraldine Hamilton ,  Akiko Mammoto ,  Tadanori Mammoto ,  Catherine Spina

    IPC分类号： C12N5/077

    CPC分类号： C12N5/0669 ,  A01N1/0247 ,  A61K35/28 ,  G01N27/44791

    摘要： The technology described herein is directed to methods and devices that can be used to induce functional organ structures to form within an implantation device by implanting it in vivo within the body of a living animal, and allowing cells and tissues to impregnate the implantation device and establish normal microenvironmental architecture and tissue-tissue interfaces. Then the contained cells and tissues can be surgically removed intact and either transplanted into another animal or maintained ex vivo by perfusing it through one or more of the fluid channels with medium and/or gases necessary for cell survival.

    摘要翻译： 本文描述的技术涉及可用于通过将其体内植入活体动物体内诱导功能性器官结构形成的方法和装置，并允许细胞和组织浸渍植入装置并建立 正常的微环境结构和组织 - 组织界面。 然后，所包含的细胞和组织可以通过外科手术移除，并移植到另一只动物中，或者通过使其通过一个或多个流体通道与细胞存活所需的培养基和/或气体灌注而保持离体。