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公开(公告)号：US20140186414A1
公开(公告)日：2014-07-03
申请号：US14122273
申请日：2012-05-31
申请人： Donald E. Ingber , Yusuke Torisawa , Geraldine Hamilton , Akiko Mammoto , Tadanori Mammoto , Catherine Spina
发明人： Donald E. Ingber , Yusuke Torisawa , Geraldine Hamilton , Akiko Mammoto , Tadanori Mammoto , Catherine Spina
IPC分类号： C12N5/077
CPC分类号： C12N5/0669 , A01N1/0247 , A61K35/28 , G01N27/44791
摘要： The technology described herein is directed to methods and devices that can be used to induce functional organ structures to form within an implantation device by implanting it in vivo within the body of a living animal, and allowing cells and tissues to impregnate the implantation device and establish normal microenvironmental architecture and tissue-tissue interfaces. Then the contained cells and tissues can be surgically removed intact and either transplanted into another animal or maintained ex vivo by perfusing it through one or more of the fluid channels with medium and/or gases necessary for cell survival.
摘要翻译： 本文描述的技术涉及可用于通过将其体内植入活体动物体内诱导功能性器官结构形成的方法和装置，并允许细胞和组织浸渍植入装置并建立 正常的微环境结构和组织 - 组织界面。 然后，所包含的细胞和组织可以通过外科手术移除，并移植到另一只动物中，或者通过使其通过一个或多个流体通道与细胞存活所需的培养基和/或气体灌注而保持离体。
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公开(公告)号：US09951313B2
公开(公告)日：2018-04-24
申请号：US14122273
申请日：2012-05-31
申请人： Donald E. Ingber , Yusuke Torisawa , Geraldine Hamilton , Akiko Mammoto , Tadanori Mammoto , Catherine Spina
发明人： Donald E. Ingber , Yusuke Torisawa , Geraldine Hamilton , Akiko Mammoto , Tadanori Mammoto , Catherine Spina
IPC分类号： C12N5/077 , A01N1/02 , A61K35/28 , G01N27/447
CPC分类号： C12N5/0669 , A01N1/0247 , A61K35/28 , G01N27/44791
摘要： The technology described herein is directed to methods and devices that can be used to induce functional organ structures to form within an implantation device by implanting it in vivo within the body of a living animal, and allowing cells and tissues to impregnate the implantation device and establish normal microenvironmental architecture and tissue-tissue interfaces. Then the contained cells and tissues can be surgically removed intact and either transplanted into another animal or maintained ex vivo by perfusing it through one or more of the fluid channels with medium and/or gases necessary for cell survival.
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公开(公告)号：US20120190659A1
公开(公告)日：2012-07-26
申请号：US13265589
申请日：2010-04-16
CPC分类号： C07J43/003 , C07J41/0005
摘要： Compounds of Structural Formula I or pharmaceutically acceptable salts thereof, are effective inhibitors of angiogenesis:
摘要翻译： 结构式I的化合物或其药学上可接受的盐是血管生成的有效抑制剂：
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公开(公告)号：US08722638B2
公开(公告)日：2014-05-13
申请号：US12999746
申请日：2009-06-19
申请人： Donald E. Ingber , Akiko Mammoto
发明人： Donald E. Ingber , Akiko Mammoto
CPC分类号： C12N15/113 , A61K31/7088 , A61K45/06 , C12N2310/14
摘要： The present invention relates to methods and compositions for promoting or inhibiting capillary endothelial (CE) cell migration, promoting or inhibiting the formation of CE networks and promoting or inhibiting angiogenesis. Some embodiments relate to methods and compositions for treating angiogenesis-related disorders characterized by loss or decreased angiogenesis. One aspect relates to the use of at least one pro-angiogenic agent selected from at least one of an p190RhoGAP inhibitor, a TFII-I inhibitor or a GATA-2 activator for promoting the formation of CE networks and angiogenesis, and methods for treating angiogenesis-related disorders characterized by loss or decreased angiogenesis. Another aspect of the invention related to use of at least one anti-angiogenic agent selected from at least one of an p190RhoGAP activator, a TFII-I activator or a GATA-2 inhibitor for inhibiting the formation of CE networks and inhibiting angiogenesis, and methods for treating angiogenesis-related disorders characterized by uncontrolled or elevated angiogenesis.
摘要翻译： 本发明涉及用于促进或抑制毛细血管内皮细胞迁移，促进或抑制CE网络形成和促进或抑制血管发生的方法和组合物。 一些实施方案涉及用于治疗以血管生成减少或减少为特征的血管生成相关病症的方法和组合物。 一方面涉及使用至少一种选自p190RhoGAP抑制剂，TFII-1抑制剂或GATA-2激活剂中的至少一种的促血管生成剂来促进CE网络和血管生成的形成，以及用于治疗血管发生的方法 以血管生成减少或减少为特征的相关疾病。 本发明的另一方面涉及使用选自p190RhoGAP激活剂，TFII-1激活剂或GATA-2抑制剂中的至少一种的至少一种抗血管生成剂来抑制CE网络的形成和抑制血管生成，以及方法 用于治疗以不受控制或升高的血管发生为特征的血管发生相关疾病。
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公开(公告)号：US20110135632A1
公开(公告)日：2011-06-09
申请号：US12999746
申请日：2009-06-19
申请人： Donald E. Ingber , Akiko Mammoto
发明人： Donald E. Ingber , Akiko Mammoto
IPC分类号： A61K39/395 , A61K31/7088 , A61K38/00 , A61P35/00 , A61P3/10 , A61P27/02 , A61P19/02 , A61P25/28 , A61P3/04 , A61P17/06 , A61P9/00 , A61P17/02
CPC分类号： C12N15/113 , A61K31/7088 , A61K45/06 , C12N2310/14
摘要： The present invention relates to methods and compositions of promoting or inhibiting capillary endothelial (CE) cell migration, promoting or inhibiting the formation of CE networks and promoting or inhibiting angiogenesis, and uses thereof. In particular, the present invention relates to methods and compositions for promoting capillary endothelial (CE) cell migration, promoting the formation of CE networks and promoting angiogenesis, and uses thereof for the purposes of treating angiogenesis-related disorders characterized by loss or decreased angiogenesis, such as ischemic injury and the like. One aspect of the invention related to use of at least one pro-angiogenic agent selected from at least one of an p190RhoGAP inhibitor, a TFII-I inhibitor or a GATA-2 activator for promoting the formation of CE networks and promoting angiogenesis, and uses thereof for the purposes of treating angiogenesis-related disorders characterized by loss or decreased angiogenesis. Another aspect of the invention related to use of at least one anti-angiogenic agent selected from at least one of an p190RhoGAP activator, a TFII-I activator or a GATA-2 inhibitor for inhibiting the formation of CE networks and inhibiting angiogenesis, and uses thereof for the purposes of treating angiogenesis-related disorders characterized by uncontrolled or elevated angiogenesis.
摘要翻译： 本发明涉及促进或抑制毛细血管内皮细胞迁移，促进或抑制CE网络形成和促进或抑制血管发生的方法和组合物及其用途。 特别地，本发明涉及用于促进毛细血管内皮细胞迁移，促进CE网络的形成和促进血管发生的方法和组合物及其用于治疗以血管生成减少或减少为特征的血管生成相关病症的用途， 例如缺血性损伤等。 本发明的一个方面涉及使用选自p190RhoGAP抑制剂，TFII-1抑制剂或GATA-2激活剂中的至少一种的至少一种促血管生成剂来促进CE网络的形成和促进血管生成，以及使用 其用于治疗以血管生成丧失或减少为特征的血管生成相关病症的目的。 本发明的另一方面涉及使用选自p190RhoGAP激活剂，TFII-1激活剂或GATA-2抑制剂中的至少一种的至少一种抗血管生成剂来抑制CE网络的形成和抑制血管生成，以及使用 以治疗以不受控制或升高的血管发生为特征的血管发生相关疾病的目的。
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公开(公告)号：US09156037B2
公开(公告)日：2015-10-13
申请号：US13144572
申请日：2010-01-15
IPC分类号： C12Q1/68 , B03C1/01 , B03C1/28 , G01N33/543 , G01N1/40
CPC分类号： B03C1/01 , B03C1/288 , B03C2201/18 , G01N1/40 , G01N33/54326 , G01N33/54366
摘要： A microfluidic device for separating target components from a source fluid includes one or more source channels connected to one or more collection channels by one or more transfer channels. The target components of the source fluid can be magnetic or bound to magnetic particles using a know binding agent. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid that is stagnant until a predefined volume of source fluid is processed or a predefined volume of target components accumulate in the collection channel, at which point collection fluid can be pumped into the collection channel to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis.
摘要翻译： 用于从源流体分离目标部件的微流体装置包括通过一个或多个传送通道连接到一个或多个收集通道的一个或多个源通道。 源流体的目标组分可以使用已知的结合剂磁性或与磁性颗粒结合。 含有磁结合的靶组分的源流体可以泵送通过微流体装置的源通道。 磁场梯度可以施加到源通道中的源流体，使得磁结合的目标分量通过传输通道迁移到收集通道中。 收集通道可以包括滞留的收集流体，直到预处理的体积的源流体被处理或预定量的目标组分积聚在收集通道中，此时收集流体可被泵入收集通道以冲洗目标组分 离开收集渠道。 随后分析目标成分进行检测和诊断。
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公开(公告)号：US09078856B2
公开(公告)日：2015-07-14
申请号：US13703765
申请日：2011-06-22
IPC分类号： A61K48/00 , A61K31/497 , A61K38/17 , A61K31/00 , A61K31/22 , A61K31/221 , A61K31/336 , A61K31/365 , A61K45/06 , A61N5/10
CPC分类号： A61K38/1709 , A61K31/00 , A61K31/22 , A61K31/221 , A61K31/336 , A61K31/365 , A61K38/177 , A61K45/06 , A61N5/10
摘要： Embodiments of the invention provide a method of improving the efficacy of an anti-cancer therapy and a method of treatment of cancer by normalizing angiogenesis in cancer. By enhancing the cell signaling pathway via a TRPV4 receptor in tumor endothelial cells, either by a TRPV4 agonist or by increasing the expression of TRPV4 in the tumor endothelial cells, the tumor endothelial cells behave normally and form normal angiogenic network for better anti-cancer therapy to the tumors.
摘要翻译： 本发明的实施方案提供了通过使癌症中的血管生成正常化来提高抗癌治疗的功效的方法和治疗癌症的方法。 通过TRPV4激动剂或通过增加TRPV4在肿瘤内皮细胞中的表达，通过肿瘤内皮细胞中的TRPV4受体增强细胞信号传导途径，肿瘤内皮细胞表现正常并形成正常的血管生成网络以获得更好的抗癌治疗 到肿瘤。
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公开(公告)号：US20140227723A1
公开(公告)日：2014-08-14
申请号：US14233553
申请日：2012-07-18
申请人： Donald E. Ingber , Michael Super , Jeffrey Charles Way , Mark J. Cartwright , Julia B. Berthet , Dinah R. Super , Martin M. Rottman , Alexander Watters
发明人： Donald E. Ingber , Michael Super , Jeffrey Charles Way , Mark J. Cartwright , Julia B. Berthet , Dinah R. Super , Martin M. Rottman , Alexander Watters
IPC分类号： C07K16/12 , G01N33/569 , C07K14/42
CPC分类号： C07K16/12 , A61K47/68 , A61K47/6815 , C07K14/42 , C07K2319/33 , G01N33/54353 , G01N33/56911 , G01N33/56916 , G01N33/56938 , G01N33/56961 , G01N2333/42 , G01N2333/4724 , Y02A50/53 , Y02A50/58
摘要： Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface. Microbe-targeting molecules and/or substrates can be regenerated after use by washing with a low pH buffer or buffer in which calcium is insoluble.
摘要翻译： 本文描述了工程化的微生物靶向或微生物结合分子，包含其的试剂盒及其用途。 微生物靶向或微生物结合分子的一些具体实施方案包含与Fc区的一部分连接的甘露糖结合凝集素或其片段的碳水化合物识别结构域。 在一些实施方案中，微生物靶向分子或微生物结合分子可以与基底（例如磁性微珠）缀合，形成微生物靶向底物（例如，微生物靶向磁性微珠）。 这样的微生物靶向分子和/或底物及其包含的试剂盒可以结合和/或捕获微生物和/或其微生物物质，因此可以用于各种应用中，例如诊断和/或治疗感染 由微生物引起，如受试者或任何环境表面的败血症。 微生物靶向分子和/或底物可以在使用后通过用不溶于钙的低pH缓冲液或缓冲液洗涤而再生。
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公开(公告)号：US20140158233A1
公开(公告)日：2014-06-12
申请号：US14116477
申请日：2012-05-09
申请人： Daniel Christopher Leslie , Karel Domansky , Geraldine A. Hamilton , Anthony Bahinski , Donald E. Ingber
发明人： Daniel Christopher Leslie , Karel Domansky , Geraldine A. Hamilton , Anthony Bahinski , Donald E. Ingber
IPC分类号： B05B15/00
摘要： The present invention is directed to systems and methods for delivering aerosolized micro-droplets into microfluidic devices. In some embodiments, the microfluidic devices are designed for the culture of living cells at an air interface. In some embodiments, the systems and methods described herein can be used to deliver aerosolized micro-droplet into detection systems and small animals, tissues, organs and organisms.
摘要翻译： 本发明涉及用于将雾化的微滴输送到微流体装置中的系统和方法。 在一些实施例中，微流体装置被设计用于在空气界面处培养活细胞。 在一些实施方案中，本文所述的系统和方法可用于将雾化的微滴输送到检测系统和小动物，组织，器官和生物中。
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公开(公告)号：US20140123578A1
公开(公告)日：2014-05-08
申请号：US14000999
申请日：2012-03-01
CPC分类号： E06B3/6715 , E06B3/66323 , E06B3/66333 , E06B3/6722 , F24D17/0015 , F24S10/50 , F24S20/63 , Y02B10/20 , Y02E10/44
摘要： A bio-inspired window can be created by applying one or more heat exchange layers to one or more surfaces of a window of a building, boat, vehicle or any other structure. The heat exchange layer can include an interconnected network or array of channels or microchannels that can be used to flow a fluid over the surface of the window. The fluid can be used to heat or cool the surface of the window panel to control the flow of heat across the window and reduce the heating or cooling energy load of building. The fluid can be heated or cooled using the ambient air in the building. The refractive index of the fluid can be adjusted to change of optical transparency properties of the window. In some embodiments, the window can appear nearly as clear as an ordinary panel of glass. In other embodiments, the window can color, block or scatter the incoming light.
摘要翻译： 可以通过将一个或多个热交换层施加到建筑物，船，车辆或任何其他结构的窗户的一个或多个表面来创建生物启发的窗口。 热交换层可以包括可用于使流体在窗口表面上流动的通道或微通道的互连网络或阵列。 流体可用于加热或冷却窗板的表面，以控制穿过窗户的热量流动，并减少建筑物的加热或冷却能量负荷。 流体可以使用建筑物中的环境空气进行加热或冷却。 可以调节流体的折射率以改变窗口的光学透明性。 在一些实施例中，窗口可以看起来像普通的玻璃板几乎一样清楚。 在其他实施例中，窗口可以着色，阻挡或散射入射光。
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