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11 条记录 (耗时 0.021 秒)

    Water-inactivatable pressure sensitive adhesive
    3.
    发明授权
    Water-inactivatable pressure sensitive adhesive 失效
    水灭活压敏胶

    公开(公告)号：US5352516A

    公开(公告)日：1994-10-04

    申请号：US828685

    申请日：1992-01-31

    申请人： Donald J. Therriault ,  Michael J. Zajaczkowski

    发明人： Donald J. Therriault ,  Michael J. Zajaczkowski

    IPC分类号： A61L15/58 ,  C09J7/02 ,  C09J151/00

    CPC分类号： C09J151/00 ,  A61L15/58 ,  C09J7/0217 ,  Y10T428/28 ,  Y10T428/2887 ,  Y10T428/2891

    摘要： A novel polymeric pressure-sensitive adhesive formulation is provided comprised of a balanced hydrophilic/hydrophobic base polymer compounded with at least one water-soluble tackifying component. Upon contact of the pressure-sensitive adhesive with excess amounts of water, the water-soluble tackifying component is caused to separate from the base polymer, thus decreasing the ability of the base polymer to function as a pressure-sensitive adhesive. The adhesive may subsequently be easily removed from any substrate to which it has been applied.

    摘要翻译： 提供了一种新型聚合物压敏粘合剂制剂，其由与至少一种水溶性增粘组分混合的平衡的亲水/疏水性基础聚合物组成。 当压敏粘合剂与过量的水接触时，使水溶性增粘组分与基础聚合物分离，从而降低了基础聚合物作为压敏粘合剂的能力。 粘合剂随后可以容易地从已经施加到其上的任何基底上去除。

    Drug flux enhancer-tolerant pressure sensitive adhesive composition
    4.
    发明授权
    Drug flux enhancer-tolerant pressure sensitive adhesive composition 失效
    药物通量增强剂耐受压敏胶组合物

    公开(公告)号：US5573778A

    公开(公告)日：1996-11-12

    申请号：US405872

    申请日：1995-03-17

    申请人： Donald J. Therriault ,  Kenneth W. Rodgers

    发明人： Donald J. Therriault ,  Kenneth W. Rodgers

    IPC分类号： A61K9/70 ,  C08F290/04 ,  C09J7/02 ,  C09J155/00 ,  A61F13/02

    CPC分类号： A61K9/7053 ,  A61K9/7061 ,  C08F290/044

    摘要： A drug flux enhancer-tolerant pressure sensitive adhesive composition is provided comprised of a mixture of (1) a percutaneous penetration enhancer to increase permeability of skin to transdermally administered pharmacologically active agents and (2) a macromer reinforced base polymer, said base polymer comprising a phase separated graft copolymer composition comprised of copolymerized monomers A and B to form a backbone polymer having polymeric moieties grafted thereto, wherein monomer A is a monomeric acrylic or methacrylic ester of a non-tertiary alcohol having from 1 to 14 carbon atoms, with the average number of carbon atoms being in the range of about 4 to 12, and a monomer B is a polar monomer which is copolymerizable with monomer A.

    摘要翻译： 提供药物通量增强剂耐受性压敏粘合剂组合物，其包含（1）经皮渗透促进剂的混合物，以增加皮肤对透皮给药的药理学活性剂的渗透性，和（2）大分子单体增强的基础聚合物，所述基础聚合物包含 相分离的接枝共聚物组合物由共聚单体A和B组成，以形成具有接枝到其上的聚合物部分的主链聚合物，其中单体A是具有1至14个碳原子的非叔醇的单体丙烯酸或甲基丙烯酸酯，平均 碳原子数在约4-12范围内，单体B是可与单体A共聚的极性单体。

    Adhesive-lined elastic condom cathether
    5.
    发明授权
    Adhesive-lined elastic condom cathether 失效
    内衬弹性避孕套导管

    公开(公告)号：US4863449A

    公开(公告)日：1989-09-05

    申请号：US191069

    申请日：1988-05-06

    申请人： Donald J. Therriault ,  Robert G. Olach ,  John S. Biersteker

    发明人： Donald J. Therriault ,  Robert G. Olach ,  John S. Biersteker

    IPC分类号： A61F5/453

    CPC分类号： A61F5/453

    摘要： A tubular elastic sheath for a condom catheter, the sheath taking the form of a thin, flexible, cylindrical member of elastic material having inner and outer surfaces and being rolled outwardly upon itself to form a torus having successively larger turns. A thin, flexible, multi-layered tape is interposed between successive turns of the rolled torus with such layers, all adhering to each other and to the catheter member, comprising a first adhesive layer, a second adhesive layer, and a highly-stretchable elastomeric layer disposed between the first and second adhesive layers. The first adhesive layer adheres to the inner surface of the catheter member and the second adhesive layer adheres to the outer surface of that member, and the relationship is such that the elastomeric layer adheres more securely to the second adhesive layer than to the first adhesive layer, and the first adhesive layer has less affinity for the elastomeric layer than each of the adhesive layers has for the surfaces of the catheter member. As a result, when the sheath is unrolled, the tape undergoes delamination with the first adhesive layer remaining upon the sheath's inner surface and the second adhesive layer, covered by the elastomeric layer, remaining on the sheath's outer surface.

    摘要翻译： 一种用于避孕套导管的管状弹性护套，该护套采取具有内表面和外表面的薄而柔性的弹性材料圆柱形构件的形式，并在其自身上向外滚动以形成具有连续较大匝数的圆环。 薄的，柔性的多层带被插入到具有这样的层的滚动圆环的连续匝之间，所有这些层全部彼此粘附到导管构件，包括第一粘合剂层，第二粘合剂层和高度可伸缩的弹性体 层，设置在第一和第二粘合剂层之间。 第一粘合剂层粘附到导管构件的内表面，并且第二粘合剂层粘合到该构件的外表面，并且这种关系使得弹性体层比第一粘合剂层更牢固地粘附到第二粘合剂层 ，并且第一粘合剂层对于弹性体层的亲和力低于每个粘合剂层对于导管构件的表面的亲和力。 结果，当鞘被展开时，胶带经历分层，第一粘合剂层保留在护套的内表面上，第二粘合剂层被弹性体层覆盖，保留在护套的外表面上。

    Water-inactivatable pressure sensitive adhesive
    6.
    发明授权
    Water-inactivatable pressure sensitive adhesive 失效
    水灭活压敏胶

    公开(公告)号：US5032637A

    公开(公告)日：1991-07-16

    申请号：US493460

    申请日：1990-03-14

    申请人： Donald J. Therriault ,  Jane E. Workinger

    发明人： Donald J. Therriault ,  Jane E. Workinger

    IPC分类号： C09J129/10 ,  C09J135/08

    CPC分类号： C09J129/10 ,  C09J135/08 ,  Y10S526/931

    摘要： A novel polymeric pressure-sensitive adhesive formulation is provided comprised of a hydrophilic base polymer compounded with at least one water-soluble tackifying component. Upon contact of the pressure-sensitive adhesive with excess amounts of water, the water-soluble tackifying component is caused to separate from the base polymer, thus decreasing the ability of the base polymer to function as a pressure-sensitive adhesive. The adhesive may subsequently be easily removed from any substrate to which it has been applied.

    摘要翻译： 提供了一种新型聚合物压敏粘合剂制剂，其由与至少一种水溶性增粘组分混合的亲水性基础聚合物组成。 当压敏粘合剂与过量的水接触时，使水溶性增粘组分与基础聚合物分离，从而降低了基础聚合物作为压敏粘合剂的能力。 粘合剂随后可以容易地从已经施加到其上的任何基底上去除。

    Pressure-sensitive hydrophilic laminate structures for use in wound dressing, transdermal and topical drug delivery
    10.
    发明授权
    Pressure-sensitive hydrophilic laminate structures for use in wound dressing, transdermal and topical drug delivery 失效
    用于伤口敷料，透皮和局部给药的压敏亲水层压结构

    公开(公告)号：US4904247A

    公开(公告)日：1990-02-27

    申请号：US782848

    申请日：1985-10-02

    申请人： Donald J. Therriault ,  Samuel C. Temin ,  Kishore R. Shah

    发明人： Donald J. Therriault ,  Samuel C. Temin ,  Kishore R. Shah

    IPC分类号： A61F13/00 ,  A61F13/02 ,  A61K9/70 ,  A61L15/58 ,  B32B7/02

    CPC分类号： A61K9/7084 ,  A61F13/0213 ,  A61F13/0253 ,  A61L15/58 ,  B32B7/02 ,  A61F2013/00604 ,  A61F2013/00748 ,  A61F2013/00757 ,  A61F2013/00765 ,  A61F2013/00846 ,  A61F2013/00906 ,  A61F2013/0091

    摘要： The present invention describes a pressure-sensitive hydrophilic laminate composite comprising contiguous layers of a tacky pressure sensitive hydrophilic polymer blend, and a non-tacky hydrophilic polymer blend. Numerous variations in individual layer formulations allow for a multitude of hydrophilic blend laminate composite structures, which are readily utilizable as wound dressings, and/or transdermal and topical delivery systems incorporating a wide range of bioactive agents. The hydrophilic laminate composite structurese are characterized by ease of application, adhesiveness to skin, high tensile strength, mechanical integrity, transparency, fluid absorbency, and highly effective bacterial barrier properties, and permeability to water vapor, oxygen and drugs and/or bioactive agents. In the preferred embodiments, they are further characterized in their ability to inhibit severe maceration of the wound as well as underlying tissue destruction upon removal.

    摘要翻译： 本发明描述了一种压敏亲水层压复合材料，其包含粘性压敏亲水性聚合物共混物的邻接层和非粘性亲水性聚合物共混物。 单独层制剂的许多变化允许多种亲水混合层压复合结构，其易于用作伤口敷料，和/或包含广泛生物活性剂的透皮和局部递送系统。 亲水性层压复合结构的特征在于易于使用，对皮肤的粘合性，高拉伸强度，机械完整性，透明度，流体吸收性和高效细菌屏障性能，以及对水蒸气，氧气和药物和/或生物活性剂的渗透性。 在优选的实施方案中，它们的进一步特征在于它们能够抑制伤口的严重浸渍以及去除时潜在的组织破坏。