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公开(公告)号：US20080220032A1
公开(公告)日：2008-09-11
申请号：US12043743
申请日：2008-03-06
CPC分类号： A61K8/87 , A61K8/8176 , A61K8/86 , A61Q11/00 , A61Q11/02
摘要： An oral care composition including a hydrophilic, aliphatic, polyether-based thermoplastic polyurethane, a glycol polymer, and a poly(N-vinyl lactam). These components form a tacky film having a thickness of about 1 mils to about 50 mils. A whitening agent, such as a peroxide, can be absorbed into the tacky film, and adapted to desorb from the tacky film to whiten teeth to which the film is joined. A method is also provided in which the components are extruded through a twin screw extruder and output to a die to produce the film. The whitening agent can be deposited on the film and absorbed by the film to form a relatively stable oral care composition including the whitening agent.
摘要翻译： 一种口腔护理组合物，其包含亲水性，脂肪族，聚醚类热塑性聚氨酯，二醇聚合物和聚（N-乙烯基内酰胺）。 这些组分形成厚度为约1密耳至约50密耳的粘性薄膜。 美白剂如过氧化物可以被吸收到粘性膜中，并且适于从粘性膜解吸，以使与该膜接合的牙齿变白。 还提供了一种方法，其中组分通过双螺杆挤出机挤出并输出到模具以制备膜。 增白剂可以沉积在薄膜上并被薄膜吸收以形成包含增白剂的相对稳定的口腔护理组合物。
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2.发明授权
公开(公告)号：US5468501A
公开(公告)日：1995-11-21
申请号：US385205
申请日：1995-02-08
申请人： Agis Kydonieus , Kishore R. Shah , Bret Berner
发明人： Agis Kydonieus , Kishore R. Shah , Bret Berner
CPC分类号： A61K9/7084 , A61K31/21 , A61M31/002
摘要： A device useful for administration of pharmacologically-active substances transdermally, orally, or by means of subdermal implant includes an impermeable backing layer, a plasticized polyvinyl chloride layer, and an adhesive layer, wherein the plasticized polyvinyl chloride layer includes from about 20 up to about 70% by weight of a polyvinyl chloride resin, from about 20 up to about 70% by weight of a plasticizer, and from about 0.5 up to about 35% by weight of a pharmacologically-active substance such as isosorbide dinitrate, nicotine, clonidine, guanfacine, indomethacin, nitroglycerin, and prostaglandin and optionally excipients.
摘要翻译： 用于通过皮下，口服或通过皮下植入来施用药理活性物质的装置包括不渗透背衬层，塑化聚氯乙烯层和粘合剂层，其中增塑聚氯乙烯层包括约20至约约 70重量％的聚氯乙烯树脂，约20至约70重量％的增塑剂和约0.5至约35重量％的药理活性物质如硝酸异山梨酯，尼古丁，可乐定， 胍法辛，吲哚美辛，硝酸甘油和前列腺素以及任选的赋形剂。
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3.发明授权
公开(公告)号：US4904247A
公开(公告)日：1990-02-27
申请号：US782848
申请日：1985-10-02
CPC分类号： A61K9/7084 , A61F13/0213 , A61F13/0253 , A61L15/58 , B32B7/02 , A61F2013/00604 , A61F2013/00748 , A61F2013/00757 , A61F2013/00765 , A61F2013/00846 , A61F2013/00906 , A61F2013/0091
摘要： The present invention describes a pressure-sensitive hydrophilic laminate composite comprising contiguous layers of a tacky pressure sensitive hydrophilic polymer blend, and a non-tacky hydrophilic polymer blend. Numerous variations in individual layer formulations allow for a multitude of hydrophilic blend laminate composite structures, which are readily utilizable as wound dressings, and/or transdermal and topical delivery systems incorporating a wide range of bioactive agents. The hydrophilic laminate composite structurese are characterized by ease of application, adhesiveness to skin, high tensile strength, mechanical integrity, transparency, fluid absorbency, and highly effective bacterial barrier properties, and permeability to water vapor, oxygen and drugs and/or bioactive agents. In the preferred embodiments, they are further characterized in their ability to inhibit severe maceration of the wound as well as underlying tissue destruction upon removal.
摘要翻译： 本发明描述了一种压敏亲水层压复合材料，其包含粘性压敏亲水性聚合物共混物的邻接层和非粘性亲水性聚合物共混物。 单独层制剂的许多变化允许多种亲水混合层压复合结构，其易于用作伤口敷料，和/或包含广泛生物活性剂的透皮和局部递送系统。 亲水性层压复合结构的特征在于易于使用，对皮肤的粘合性，高拉伸强度，机械完整性，透明度，流体吸收性和高效细菌屏障性能，以及对水蒸气，氧气和药物和/或生物活性剂的渗透性。 在优选的实施方案中，它们的进一步特征在于它们能够抑制伤口的严重浸渍以及去除时潜在的组织破坏。
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公开(公告)号：US4462665A
公开(公告)日：1984-07-31
申请号：US415571
申请日：1982-09-07
申请人： Kishore R. Shah
发明人： Kishore R. Shah
CPC分类号： G02B1/043 , B29D11/0073 , B32B27/08 , Y10S428/913 , Y10T428/24942
摘要： Polymer blends capable of forming hydrogels upon immersion in water are bonded by heat and pressure alone to water-resistant polymer compositions compatible with vinyl lactam polymers to form laminates. Bonding can also be achieved by casting on the surface of the polymer composition a solution of the blend in a solvent inert to the polymer composition and evaporating the solvent. The blends are optically clear blends of vinyl lactam polymers or copolymers with water insoluble copolymers of a hydrophobic water-insoluble ethylenically unsaturated monomer, an ethylenically unsaturated monomer containing an acid group, and optionally a hydrophilic ethylenically unsaturated monomer free from acidic groups.
摘要翻译： 能够在浸入水中形成水凝胶的聚合物共混物通过热和压力单独粘合到与乙烯基内酰胺聚合物相容的耐水性聚合物组合物中以形成层压体。 粘合也可以通过在聚合物组合物的表面上浇铸共混物在对聚合物组合物惰性且溶剂蒸发的溶剂中的溶液来实现。 共混物是乙烯基内酰胺聚合物或共聚物与疏水性不溶于水的烯键式不饱和单体的水不溶性共聚物，含有酸基的烯属不饱和单体和任选的不含酸性基团的亲水性烯属不饱和单体的光学透明共混物。
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公开(公告)号：US4306039A
公开(公告)日：1981-12-15
申请号：US142986
申请日：1980-04-23
申请人： Kishore R. Shah , Samuel C. Temin
发明人： Kishore R. Shah , Samuel C. Temin
CPC分类号： F16J15/3284 , C08L33/064 , C09J133/08 , C09K3/10 , C08L39/00 , C09K2200/0615 , C09K2200/0622 , C09K2200/0625
摘要： A non-tacky thermoplastic elastomeric composition which is an optically clear blend of (A) a copolymer of ethyl or butyl acrylate or mixtures thereof with from 2 to 10% by weight of a copolymerizable ethylenic monomer containing an acid group and (B) from 2 to 15%, by weight of the blend, of a water-soluble homopolymer of a vinyl lactam having the structure ##STR1## in which X represents an alkylene bridge having three to five carbon atoms, or from 2 to 30%, by weight of the blend, of a copolymer of said lactam with from 1 to 80 mole percent of a copolymerizable monomer containing a polymerizable ethylenic unsaturation, the vinyl lactam polymer or copolymer having a glass transistion temperature from 20.degree. to 250.degree. C.
摘要翻译： 一种非粘性热塑性弹性体组合物，其是（A）丙烯酸乙酯或丁酯或其混合物与2-10重量％含有酸基团的可共聚乙烯单体和（B）的共聚物的光学透明共混物， 至15重量％的具有结构“IMAGE”的乙烯基内酰胺的水溶性均聚物，其中X表示具有3至5个碳原子的亚烷基桥，或2至30重量％ 所述内酰胺与1至80摩尔％的含可聚合烯属不饱和度的可共聚单体的共聚物的共混物，所述乙烯基内酰胺聚合物或共聚物的玻璃化转变温度为20-250℃。
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公开(公告)号：US4300820A
公开(公告)日：1981-11-17
申请号：US201349
申请日：1980-10-27
申请人： Kishore R. Shah
发明人： Kishore R. Shah
IPC分类号： A61L15/58 , A61L17/14 , A61L29/08 , A61L29/14 , C01B21/26 , C08L39/04 , C08L39/06 , C09J133/06 , C09J139/06 , C08L45/00 , G02C7/04
CPC分类号： C09J133/064 , A61L15/585 , A61L17/145 , A61L29/085 , A61L29/145 , C01B21/26 , C08L39/06 , C09J139/06 , G02B1/04 , G02B1/043 , C08L39/04 , C09J2201/606
摘要： A composition capable of absorbing more than 45% of its weight of water without dissolution at room temperature to form a hydrogel is made by blending (1) 40 to 98% by weight of water-soluble polymer of a vinyl lactam having the structure ##STR1## in which X represents an alkylene bridge having three to five carbon atoms or a copolymer thereof with 1 to 90 mole percent of a copolymerizable monomer containing a polymerizable ethylenic unsaturation; and (2) 2 to 60% by weight of a water-insoluble copolymer formed of 50% to 90% by weight based on the total copolymer of a hydrophobic water-insoluble ethylenically unsaturated monomer, 2 to 12% by weight of an ethylenically unsaturated monomer containing an acid group, and 0 to 50% by weight of a hydrophilic ethylenically unsaturated monomer free from acidic groups.
摘要翻译： 通过混合（1）40至98重量％的具有结构
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公开(公告)号：US08257719B2
公开(公告)日：2012-09-04
申请号：US12043743
申请日：2008-03-06
CPC分类号： A61K8/87 , A61K8/8176 , A61K8/86 , A61Q11/00 , A61Q11/02
摘要： An oral care composition including a hydrophilic, aliphatic, polyether-based thermoplastic polyurethane, a glycol polymer, and a poly(N-vinyl lactam). These components form a tacky film having a thickness of about 1 mils to about 50 mils. A whitening agent, such as a peroxide, can be absorbed into the tacky film, and adapted to desorb from the tacky film to whiten teeth to which the film is joined. A method is also provided in which the components are extruded through a twin screw extruder and output to a die to produce the film. The whitening agent can be deposited on the film and absorbed by the film to form a relatively stable oral care composition including the whitening agent.
摘要翻译： 一种口腔护理组合物，其包含亲水性，脂肪族，聚醚类热塑性聚氨酯，二醇聚合物和聚（N-乙烯基内酰胺）。 这些组分形成厚度为约1密耳至约50密耳的粘性薄膜。 美白剂如过氧化物可以被吸收到粘性膜中，并且适于从粘性膜解吸，以使与该膜接合的牙齿变白。 还提供了一种方法，其中组分通过双螺杆挤出机挤出并输出到模具以制备膜。 增白剂可以沉积在薄膜上并被薄膜吸收以形成包含增白剂的相对稳定的口腔护理组合物。
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公开(公告)号：US5827525A
公开(公告)日：1998-10-27
申请号：US711754
申请日：1996-09-10
申请人： Wei-Chi Liao , Agis Kydonieus , Kishore R. Shah
发明人： Wei-Chi Liao , Agis Kydonieus , Kishore R. Shah
IPC分类号： A61K9/70 , A61K9/00 , A61K31/198 , A61K38/55 , A61F13/00
CPC分类号： A61K31/198 , A61K38/556 , A61K9/006
摘要： A unidirectional buccal delivery system for the delivery of therapeutic agents over an extended period of time. The delivery system includes a matrix for releasing the drug into the oral cavity at a sustained rate and a means for securing the matrix to the palate or other adequate regions in the oral cavity.
摘要翻译： 用于在延长的时间段内递送治疗剂的单向颊部递送系统。 递送系统包括用于以持续速率将药物释放到口腔中的基质和用于将基质固定到口腔中的腭或其它适当区域的装置。
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9.发明授权
公开(公告)号：US5028431A
公开(公告)日：1991-07-02
申请号：US406811
申请日：1989-09-13
申请人： Thomas J. Franz , Kishore R. Shah , Agis Kydonieus
发明人： Thomas J. Franz , Kishore R. Shah , Agis Kydonieus
CPC分类号： A61K9/703 , A61K31/57 , A61K9/7053
摘要： Described is an article for the controlled release and delivery to animal tissue of a pharmacologically active agent with or without an excipient and/or enhances which may be a causative factor in the occurrence of non-allergic or allergic contact dermatitis comprising an anti-dermatitis substance.
摘要翻译： 描述了一种用于控制释放和递送具有或不具有赋形剂的药理学活性剂的动物组织和/或增强其可能是发生非过敏性或过敏性接触性皮炎的致病因素，其包含抗皮炎物质 。
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10.发明授权
公开(公告)号：US4767808A
公开(公告)日：1988-08-30
申请号：US122862
申请日：1987-11-19
申请人： Agis Kydonieus , Kishore R. Shah , Bret Berner
发明人： Agis Kydonieus , Kishore R. Shah , Bret Berner
IPC分类号： A61K9/70 , A61K31/165 , A61K31/21 , A61K31/34 , A61K31/405 , A61K31/415 , A61K31/465 , A61K31/557 , A61M31/00 , A61K9/00
CPC分类号： A61K31/165 , A61K31/21 , A61K31/34 , A61K31/405 , A61K31/415 , A61K31/465 , A61K31/557 , A61K9/703 , A61K9/7084 , A61M31/002
摘要： Described is an article of manufacture useful for administration of pharmacologically-active substances, transdermally, orally or by means of subdermal implant comprising a solid vinyl plastisol layer for contacting a patient's tissue, internally or externally, the layer containing from about 20 up to about 70% by weight of a polyvinyl chloride resin or a polyvinyl chloride-polyvinyl acetate copolymer containing a minor proportion of vinyl acetate; from about 20-70% plasticizer composition; from about 0.5 up to 35% of a pharmacologically-active substance such as isosorbide dinitrate, nicotine, clonidine, guanfacine, indomethacin, glyceryl trinitrate and prostaglandin and optionally excipients. Also described is the novel plasticizer-polyvinyl chloride composition of matter comprising 1-dodecylhexahydro-2H-azepin-2-one and polyvinyl chloride resin taken together with a pharmacologically-active substance wherein the 1-dodecylhexahydro-2H-azepin-2-one not only acts as a plasticizer but also acts as a penetration enhancer (through tissue) for the pharmacologically-active substance.
摘要翻译： 描述了可用于施用药理学活性物质，经皮，口服或通过皮下植入的制剂，其包括固体乙烯基增塑溶胶层，用于在内部或外部将患者组织接触含有约20至约70的层 重量百分比的聚氯乙烯树脂或含有少量醋酸乙烯酯的聚氯乙烯 - 聚乙酸乙烯酯共聚物; 约20-70％的增塑剂组成; 约0.5至35％的药理学活性物质如硝酸异山梨酯，尼古丁，可乐定，胍法辛，吲哚美辛，三硝酸甘油酯和前列腺素以及任选的赋形剂。 还描述了包含1-十二烷基六氢-2H-氮杂-2-酮和聚氯乙烯树脂与药理活性物质一起的物质的新型增塑剂 - 聚氯乙烯组合物，其中1-十二烷基六氢-2H-氮杂-2-酮不 仅用作增塑剂，但也用作药理活性物质的渗透促进剂（通过组织）。
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