公开(公告)号：US5674921A

公开(公告)日：1997-10-07

申请号：US382325

申请日：1995-02-01

申请人： Donald W. Regula ,  Michael F. Bregen ,  Stuart L. Cooper ,  Dennis D. Jamiolkowski ,  Rao S. Bezwada

发明人： Donald W. Regula ,  Michael F. Bregen ,  Stuart L. Cooper ,  Dennis D. Jamiolkowski ,  Rao S. Bezwada

IPC分类号： A61L31/06 ,  A61L31/14 ,  C08F290/14 ,  C08G18/67 ,  A61B17/08 ,  B29C35/02 ,  C08L75/16 ,  G03C5/00

CPC分类号： A61L31/06 ,  A61L31/148 ,  C08F290/147 ,  C08G18/672 ,  C08G2230/00

摘要： A radiation-curable prepolymer of a polyurethane endtipped with an hydroxy (acrylate or methacrylate) is disclosed. The polyurethane is derived from the reaction of a polyfunctional isocyanate with a hydrolyzable oligomer of an anhydrous cyclic ester of an hydroxy acid. Crosslinked polymers prepared by irradiating the prepolymers are also disclosed. The crosslinked polymers are bioabsorbable and biocompatible with bodily tissue, yet still maintain the outstanding mechanical properties one would expect from a polyurethane. The prepolymers and crosslinked polymers are especially well-suited for the fabrication of surgical devices, particularly wound closure devices such as surgical staples and clips, in a stereolithography apparatus.

摘要翻译： 公开了一种端接有羟基（丙烯酸酯或甲基丙烯酸酯）的聚氨酯的可辐射固化预聚物。 聚氨酯衍生自多官能异氰酸酯与羟基酸的无水环状酯的可水解低聚物的反应。 还公开了通过照射预聚物制备的交联聚合物。 交联聚合物是生物可吸收的并且与身体组织生物相容，但仍然保持着从聚氨酯所期望的突出的机械性能。 预聚物和交联聚合物特别适用于在立体光刻设备中制造手术装置，特别是诸如外科缝钉和夹子的伤口闭合装置。

公开(公告)号：US5550172A

公开(公告)日：1996-08-27

申请号：US385015

申请日：1995-02-07

申请人： Donald W. Regula ,  Kevin Cooper ,  Michael F. Bregen ,  Shawn T. Huxel ,  Daniel C. Rosenman

发明人： Donald W. Regula ,  Kevin Cooper ,  Michael F. Bregen ,  Shawn T. Huxel ,  Daniel C. Rosenman

IPC分类号： A61L24/00 ,  A61L24/02 ,  A61L24/04 ,  A61L24/06 ,  A61L27/00 ,  C08K5/10 ,  A61B17/56 ,  A61B17/58 ,  C01B15/16

CPC分类号： A61L24/046 ,  A61L24/02 ,  A61L24/06

摘要： A process for enhancing the security of implantable surgical devices secured to bone tissue comprising implanting in bone tissue a surgical device with a biocompatible adhesive and/or sealant selected from the group consisting of: p1 (a) a material made from monomers of the formula:CHR.sup.1 .dbd.CX.sup.1 Y.sup.1 wherein X.sup.1 and Y.sup.1 are each strong electron withdrawing groups, and R.sup.1 is hydrogen or, provided that X.sup.1 and Y.sup.1 are both cyano groups, a C.sub.1 -C.sub.4 alkyl group;(b) a semi-crystalline aliphatic poly(ester) of the formula:[--0--R.sup.11 --C(0)--].sub.y, wherein R.sup.11 is selected from the group consisting of --CR.sup.12 H--, --(CH.sub.2).sub.3 --0--, --CH.sub.2 --CH.sub.2 --O--CH.sub.2 --, CR.sub.12 H--CH.sub.2, --(CH.sub.2).sub.4 --, --(CH.sub.2).sub.z --O--C(O)-- and --(CH.sub.2).sub.z --C(O)--CH.sub.2 --; R.sup.12 is hydrogen or methyl; z is an integer in the range of from 1 to 7 and y is an integer in the range of from about 10 to about 20,000; and(c) a slurry of water and a calcium containing compounds with the general formula:M.sup.2+.sub.10-n N.sup.1+.sub.2n (WO.sub.4.sup.3-).sub.6 mU.sup.2- where n is an integer from 1 to 10, and m is 2 when x is 1, or m is 1 when x is 2, M and N are alkali or alkaline earth metals; WO.sub.4 is an acid radical and w is phosphorus, vanadium, sulfur, silicon, or is substituted in whole or part with carbonate (CO.sub.3.sup.2-); and U is a halide, hydroxide, or carbonate; provided in an amount effective to increase the amount of force necessary to remove the implanted surgical device. Additionally provided is a surgical device that is at least partially coated with at least one biocompatible adhesive and/or sealant.

摘要翻译： 一种用于增强固定到骨组织的可植入手术装置的安全性的方法，包括在骨组织中植入具有选自以下的生物相容性粘合剂和/或密封剂的手术装置：p1（a）由下式的单体制成的材料： CHR1 = CX1Y1，其中X1和Y1各自是强吸电子基团，R1是氢，或者X1和Y1都是氰基，C1-C4烷基; （b）下式的半结晶脂族聚（酯）：[-0-R11-C（O） - ] y，其中R11选自-CR12H - ， - （CH2）3-0 - ， - CH 2 - （CH 2）4 - ， - （CH 2）z OC（O） - 和 - （CH 2）z C（O） R 12是氢或甲基; z是1至7的整数，y是约10至约20,000的整数; 和（c）水和含钙化合物的浆料，通式为：M2 + 10-nN1 + 2n（WO43-）6mU2-其中n为1至10的整数，当x为1时，m为2， 或当x为2时m为1，M和N为碱金属或碱土金属; WO4是酸基，w是磷，钒，硫，硅，或全部或部分被碳酸酯（CO32-）取代; U是卤化物，氢氧化物或碳酸盐; 提供有效量以增加去除植入的手术装置所需的力的量。 另外提供了至少部分地涂覆有至少一种生物相容性粘合剂和/或密封剂的手术装置。

公开(公告)号：US5346501A

公开(公告)日：1994-09-13

申请号：US14019

申请日：1993-02-05

申请人： Donald W. Regula ,  Michael F. Bregen ,  Zoltan Szabo ,  Barry N. Gardiner

发明人： Donald W. Regula ,  Michael F. Bregen ,  Zoltan Szabo ,  Barry N. Gardiner

IPC分类号： A61B17/115 ,  A61B17/00 ,  A61B17/11

CPC分类号： A61B17/1114 ,  A61B2017/00004

摘要： A mechanism and applier therefor which is capable of inverted anastomosis of two lumens by an absorbable fastener. The fastener is made from two washer-like plate assemblies and a pair of introducers. Each such plate assembly has slots to receive latching prongs protruding from the other plate, and pins to impale tissue. Fastening is done through an applier that causes the pins to pierce the tissue, and causes a knife blade to cut through excess tissue. Fastening is done by attaching fastener halves. Insertion and removal of the fastener and applier optimally is done in an endoscopic procedure through a trocar or through the surgical incision in an open procedure. The system can be used such that the plates can be placed to properly set gaps between and anastomose tissue. The introducer portion will soften intraluminally and be expelled, in about 24 hours. The coupler portion will remain in place for 2-3 weeks, typically, and then fragment and be expelled with the feces.

摘要翻译： 其机构和应用者能够通过可吸收的紧固件反转两个腔的吻合。 紧固件由两个垫圈状板组件和一对导向器组成。 每个这样的板组件具有槽以接收从另一个板突出的锁定插脚，以及用于将突起组织的销钉。 紧固通过施加器完成，使得销刺穿组织，并且使刀片切割过多的组织。 通过安装紧固件半部来完成紧固。 通过套管针或通过开放手术中的外科切口在内窥镜手术中最佳地插入和移除紧固件和施放器。 可以使用该系统，使得板可以被放置成适当地设置和吻合组织之间的间隙。 导引器部分将在约24小时内内向软化并被排出。 联结器部分通常保持2-3周，然后碎片并用粪便排出。

公开(公告)号：US5304204A

公开(公告)日：1994-04-19

申请号：US15707

申请日：1993-02-09

申请人： Michael F. Bregen

发明人： Michael F. Bregen

IPC分类号： A61B17/08 ,  A61B17/064 ,  A61B17/00

CPC分类号： A61B17/0644 ,  Y10S411/904 ,  Y10S411/92

摘要： A self-closing receiverless surgical fastener comprises a fastener body of biocompatible or bioabsorbable material including a bridge member and at least two tines extending from opposite ends of the bridge member. The tines are resiliently deformable from a normally closed position with the distal ends of the tines pointing toward each other to an open position with the distal ends of the tines extending substantially parallel to each other for penetrating into tissue. The tines are resiliently returnable to the closed position with the distal ends of the tines pointing toward each other to secure the fastener body to the tissue.

摘要翻译： 自闭合无接收器手术紧固件包括生物相容性或生物可吸收材料的紧固件主体，其包括桥构件和从桥构件的相对端延伸的至少两个齿。 尖齿可以从常闭位置弹性变形，其中齿的远端彼此指向彼此到达打开位置，其中尖端的远端基本上彼此平行地延伸以穿透组织。 尖齿可弹性地返回到关闭位置，其中齿的远端指向彼此以将紧固件固定到组织上。