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    Substituted cyclopentenes, their preparation and their use for chiral scaffolds
    4.
    发明授权
    Substituted cyclopentenes, their preparation and their use for chiral scaffolds 失效
    取代的环戊烯，它们的制备及其在手性支架中的用途

    公开(公告)号：US06593489B1

    公开(公告)日：2003-07-15

    申请号：US09659482

    申请日：2000-09-11

    申请人： Mark Edward Brennan Smith ,  Nadine Derrien

    发明人： Mark Edward Brennan Smith ,  Nadine Derrien

    IPC分类号： C07C6974

    CPC分类号： C07D263/52 ,  C07B2200/07 ,  C07C227/32 ,  C07C271/56 ,  Y02P20/55 ,  C07C229/48

    摘要： 3,4-Disubstituted-1-cyclopentene compounds, in substantially enantiopure form, have the relative stereochemistry according to formula (1A) or (1B) including the opposite enantiomers thereof, wherein R1 is either COOX, wherein X is selected from the group consisting of alkyl, H, and a salt-forming cation, or CH2OH, whererin the hydroxy group is optionally protected; R2 is H or a protecting group; R3 is H or alkyl, and R4 is selected from the group consisting of H, alkoxy, alkyl, aryl, and aralkyl; or, in the case of formula (1A), R2 and R4 are linked to form an oxazolidonone ring. These compounds can be used to prepare a series of complementary stereochemcially varied cyclopentane scaffolds.

    摘要翻译： 具有基本对映体形式的3,4-二取代-1-环戊烯化合物具有根据式（1A）或（1B）的相对立体化学，包括其相对的对映异构体，其中R 1是COOX，其中X选自烷基 ，H和成盐阳离子或CH 2 OH，其中羟基任选被保护; R 2是H或保护基; R 3是H或烷基，R 4选自H，烷氧基，烷基，芳基， 和芳烷基; 或者在式（1A）的情况下，R 2和R 4连接形成恶唑烷酮环。这些化合物可用于制备一系列互补的立体化学变化的环戊烷支架。