公开(公告)号：US08552065B2

公开(公告)日：2013-10-08

申请号：US13558119

申请日：2012-07-25

申请人： Dong Heon Shin

发明人： Dong Heon Shin

IPC分类号： A61K31/165

CPC分类号： C07C235/56 ,  A61K8/42 ,  A61K31/167 ,  A61Q19/02 ,  C07C233/65 ,  C07C233/75 ,  C07C233/76 ,  C07C233/81 ,  C07C255/57

摘要： The present invention relates to a novel biarylamide derivative and a pharmaceutical composition or a cosmetic composition comprising the same as an active ingredient. More particularly, the present invention relates to a novel biarylamide derivative, a pharmaceutical composition or a cosmetic composition for preventing or treating a pigmentation disorder caused by an abnormal excess of melanin or a disease caused by melanocyte hyperplasia comprising the same as an active ingredient. The biarylamide derivative of the present invention inhibits melanin production and thus inhibits melanocyte hyperplasia. Therefore, a cosmetic composition comprising the biarylamide is excellent in a whitening effect, and a pharmaceutical composition comprising the biarylamide is effective in the prevention or treatment of pigmentation disorders of skin such as lentigo, melasma, freckle, etc. and malignant melanoma.

摘要翻译： 本发明涉及一种新颖的联芳基酰胺衍生物和药物组合物或包含其作为活性成分的化妆品组合物。 更具体地说，本发明涉及一种用于预防或治疗由黑素细胞异常过度引起的色素沉着障碍或由包含其作为活性成分的黑素细胞增生引起的疾病的新颖的联芳芳酰胺衍生物，药物组合物或化妆品组合物。 本发明的联芳基酰胺衍生物抑制黑色素的产生，从而抑制黑素细胞增生。 因此，包含联芳基酰胺的化妆品组合物具有优异的美白效果，并且包含联芳基酰胺的药物组合物可有效预防或治疗皮肤如色素沉着病，如紫草，黑斑病，雀斑等，以及恶性黑素瘤。

公开(公告)号：US20120071424A1

公开(公告)日：2012-03-22

申请号：US13236080

申请日：2011-09-19

申请人： Dong Heon Shin ,  Tae Yoon Kim

发明人： Dong Heon Shin ,  Tae Yoon Kim

IPC分类号： A61K31/7008 ,  A61P35/00 ,  A61P17/00 ,  A61P17/12 ,  A61P17/10 ,  A61P17/08 ,  C07H5/06 ,  A61P17/06

CPC分类号： A61K31/341

摘要： Disclosed is a novel use of phytosphingosine. More particularly, disclosed are a composition for preventing or treating hyper-proliferative skin diseases comprising pachastrissamine as an active ingredient, a use of pachastrissamine or a pharmaceutically acceptable salt thereof for preparing a preventing/therapeutic agent of hyper-proliferative skin diseases, and a method for treating hyper-proliferative skin diseases administering an effective amount of pachastrissamine or a pharmaceutically acceptable salt thereof to a subject in need thereof. The pachastrissamine inhibits the degradation of FoxO3a protein and increases the expression of FoxO3a protein. Thus, the inventive pharmaceutical composition has a preventing of treating effect on hyper-proliferative diseases by inducing apoptosis of hyper-proliferative cells and inhibiting the cell cycle. Accordingly, the disclosed composition, a use, and the method can be used for preventing or treating various hyper-proliferative skin diseases such as skin cancer or psoriasis.

摘要翻译： 披露了植物鞘氨醇的新用途。 更具体地，公开了一种用于预防或治疗高增殖性皮肤疾病的组合物，其包括作为活性成分的蓬曲沙胺，用于制备高增殖性皮肤疾病的预防/治疗剂的波多沙胺或其药学上可接受的盐的方法， 用于治疗对有需要的受试者施用有效量的多沙普坦或其药学上可接受的盐的增殖性皮肤病。 帕沙星可抑制FoxO3a蛋白的降解，增加FoxO3a蛋白的表达。 因此，本发明的药物组合物通过诱导高增殖细胞的细胞凋亡和抑制细胞周期来防止治疗对增殖性疾病的作用。 因此，所公开的组合物，用途和方法可用于预防或治疗各种高增殖性皮肤疾病如皮肤癌或牛皮癣。

公开(公告)号：US20120289595A1

公开(公告)日：2012-11-15

申请号：US13558119

申请日：2012-07-25

申请人： Dong Heon Shin

发明人： Dong Heon Shin

IPC分类号： A61K31/167 ,  C07C235/56 ,  A61K31/277 ,  A61K31/245 ,  C07C255/60 ,  C07C233/65 ,  A61P17/00

CPC分类号： C07C235/56 ,  A61K8/42 ,  A61K31/167 ,  A61Q19/02 ,  C07C233/65 ,  C07C233/75 ,  C07C233/76 ,  C07C233/81 ,  C07C255/57

摘要： The present invention relates to a novel biarylamide derivative and a pharmaceutical composition or a cosmetic composition comprising the same as an active ingredient. More particularly, the present invention relates to a novel biarylamide derivative, a pharmaceutical composition or a cosmetic composition for preventing or treating a pigmentation disorder caused by an abnormal excess of melanin or a disease caused by melanocyte hyperplasia comprising the same as an active ingredient. The biarylamide derivative of the present invention inhibits melanin production and thus inhibits melanocyte hyperplasia. Therefore, a cosmetic composition comprising the biarylamide is excellent in a whitening effect, and a pharmaceutical composition comprising the biarylamide is effective in the prevention or treatment of pigmentation disorders of skin such as lentigo, melasma, freckle, etc. and malignant melanoma.

摘要翻译： 本发明涉及一种新颖的联芳基酰胺衍生物和药物组合物或包含其作为活性成分的化妆品组合物。 更具体地说，本发明涉及一种用于预防或治疗由黑素细胞异常过度引起的色素沉着障碍或由包含其作为活性成分的黑素细胞增生引起的疾病的新颖的联芳芳酰胺衍生物，药物组合物或化妆品组合物。 本发明的联芳基酰胺衍生物抑制黑色素的产生，从而抑制黑素细胞增生。 因此，包含联芳基酰胺的化妆品组合物具有优异的美白效果，并且包含联芳基酰胺的药物组合物可有效预防或治疗皮肤如色素沉着病，如紫草，黑斑病，雀斑等，以及恶性黑素瘤。

公开(公告)号：US20120093796A1

公开(公告)日：2012-04-19

申请号：US12532539

申请日：2008-03-24

申请人： Dong Heon Shin ,  Tae Yoon Kim

发明人： Dong Heon Shin ,  Tae Yoon Kim

IPC分类号： A61K38/44 ,  A61P3/10 ,  A61P29/00 ,  A61P27/06 ,  A61P9/10 ,  A61P27/02 ,  A61P27/14 ,  A61P17/10 ,  A61P37/08 ,  A61P17/06 ,  A61P11/06 ,  C12N9/02 ,  C12N15/63 ,  A61K48/00 ,  A61P11/02 ,  A61P17/00 ,  A61P35/00

CPC分类号： A61K38/446 ,  A61K38/00 ,  C12N9/0089 ,  C12Y115/01001

摘要： The present invention relates to compositions for preventing or treating angiogenesis-mediated diseases or allergic diseases which contain, as an active ingredient, an EC-SOD protein or a vector having a polynucleotide encoding thereof. The EC-SOD protein or the vector having a polynucleotide encoding the EC-SOD protein has the effect on inhibiting angiogenesis by inhibiting the expression of VEGF and MMP-9 which induce angiogenesis. Therefore, the EC-SOD protein or the vector may be useful for preventing or treating angiogenesis-mediated diseases. And the EC-SOD protein or the vector having a polynucleotide encoding said EC-SOD protein also has the effect on inhibiting over-differentiation of Th2 cells which cause allergic diseases, inhibiting transcription factor (NF-κ B), and reducing degranulation of human mast cells. Accordingly, the EC-SOD protein or the vector may be useful for preventing or treating allergy diseases. In addition, the inventive method for preparing an EC-SOD protein may be used in preparing an EC-SOD protein having the activity on a large scale. Therefore, the inventive method may be useful industrially.

摘要翻译： 本发明涉及用于预防或治疗血管生成介导的疾病或过敏性疾病的组合物，其含有作为活性成分的EC-SOD蛋白或其编码多核苷酸的载体。 EC-SOD蛋白或具有编码EC-SOD蛋白的多核苷酸的载体通过抑制诱导血管发生的VEGF和MMP-9的表达，具有抑制血管发生的作用。 因此，EC-SOD蛋白或载体可用于预防或治疗血管生成介导的疾病。 并且具有编码所述EC-SOD蛋白质的多核苷酸的EC-SOD蛋白或载体也具有抑制Th2细胞过度分化的作用，所述Th2细胞引起过敏性疾病，抑制转录因子（NF-κB）和减少脱颗粒 人体肥大细胞。 因此，EC-SOD蛋白或载体可用于预防或治疗过敏性疾病。 此外，本发明的制备EC-SOD蛋白的方法可用于制备具有大规模活性的EC-SOD蛋白。 因此，本发明的方法在工业上可能是有用的。

公开(公告)号：US20110207807A1

公开(公告)日：2011-08-25

申请号：US13061836

申请日：2009-09-02

申请人： Tae Yoon Kim ,  Dong Heon Shin

发明人： Tae Yoon Kim ,  Dong Heon Shin

IPC分类号： A61K31/352 ,  C07D311/22 ,  A61P29/00 ,  A61P37/08 ,  A61P17/00 ,  A61P17/06 ,  A61P17/10

CPC分类号： A61Q19/06 ,  A61K8/498 ,  A61K31/352 ,  A61K2800/92

摘要： The present disclosure relates to a new use of homoisoflavanone or a salt thereof. More particularly, it relates to a pharmaceutical composition for the prevention and treatment of inflammatory diseases or allergic diseases comprising homoisoflavanone represented by Chemical Formula 1 or a salt thereof, a use of homoisoflavanone or a salt thereof in the manufacture of an agent for the preventing and treating of inflammatory diseases or allergic diseases, and a method for treating inflammatory diseases or allergic diseases including administering an effective dose of homoisoflavanone or a salt thereof to a subject in need thereof.

摘要翻译： 本公开内容涉及高分子异黄酮或其盐的新用途。 更具体地说，本发明涉及一种用于预防和治疗由化学式1表示的高分子异黄酮或其盐的炎症性疾病或过敏性疾病的药物组合物，使用异丙基黄酮或其盐在制备用于预防和/ 治疗炎性疾病或过敏性疾病，以及治疗炎性疾病或过敏性疾病的方法，包括向有需要的受试者施用有效剂量的异丙基黄酮或其盐。

公开(公告)号：US08609718B2

公开(公告)日：2013-12-17

申请号：US13236080

申请日：2011-09-19

申请人： Dong Heon Shin ,  Tae Yoon Kim

发明人： Dong Heon Shin ,  Tae Yoon Kim

IPC分类号： A61K31/34

CPC分类号： A61K31/341

摘要： Disclosed is a novel use of phytosphingosine. More particularly, disclosed are a composition for preventing or treating hyper-proliferative skin diseases comprising pachastrissamine as an active ingredient, a use of pachastrissamine or a pharmaceutically acceptable salt thereof for preparing a preventing/therapeutic agent of hyper-proliferative skin diseases, and a method for treating hyper-proliferative skin diseases administering an effective amount of pachastrissamine or a pharmaceutically acceptable salt thereof to a subject in need thereof. The pachastrissamine inhibits the degradation of FoxO3a protein and increases the expression of FoxO3a protein. Thus, the inventive pharmaceutical composition has a preventing of treating effect on hyper-proliferative diseases by inducing apoptosis of hyper-proliferative cells and inhibiting the cell cycle. Accordingly, the disclosed composition, a use, and the method can be used for preventing or treating various hyper-proliferative skin diseases such as skin cancer or psoriasis.

摘要翻译： 披露了植物鞘氨醇的新用途。 更具体地，公开了一种用于预防或治疗高增殖性皮肤疾病的组合物，其包括作为活性成分的蓬曲沙胺，用于制备高增殖性皮肤疾病的预防/治疗剂的波多沙胺或其药学上可接受的盐的方法， 用于治疗对有需要的受试者施用有效量的多沙普坦或其药学上可接受的盐的增殖性皮肤病。 帕沙星可抑制FoxO3a蛋白的降解，增加FoxO3a蛋白的表达。 因此，本发明的药物组合物通过诱导高增殖细胞的细胞凋亡和抑制细胞周期来防止治疗对增殖性疾病的作用。 因此，所公开的组合物，用途和方法可用于预防或治疗各种高增殖性皮肤疾病如皮肤癌或牛皮癣。

公开(公告)号：US08367373B2

公开(公告)日：2013-02-05

申请号：US12514730

申请日：2007-11-15

申请人： Tae Yoon Kim ,  Sang Hoon Kim ,  Ik Soo Jeon ,  Sung Jun Byun ,  Dong Heon Shin ,  Nam Soo Kim

发明人： Tae Yoon Kim ,  Sang Hoon Kim ,  Ik Soo Jeon ,  Sung Jun Byun ,  Dong Heon Shin ,  Nam Soo Kim

IPC分类号： C12P21/02

CPC分类号： C07K14/465 ,  C12N15/85 ,  C12N2830/008 ,  C12N2830/90

摘要： An oviduct specific expression promoter and a recombinant expression vector including the same. A promoter of an AGR2 gene is expressed specifically in the chicken oviduct, and a recombinant expression vector includes the promoter and a desired gene for encoding a desired protein. The oviduct specific promoter and the recombinant expression vector including the promoter can induce the expression of a protein specifically in the oviduct, i.e., an organ that secrets proteins so as to accumulate with a large amount in the egg. Accordingly, the oviduct specific promoter and the recombinant expression vector of the present invention can be advantageously used to produce transformed chickens, which can massively yield useful elements of high added value, produce functional eggs, and improve the economic traits of the poultry.

摘要翻译： 输卵管特异性表达启动子和包含其的重组表达载体。 AGR2基因的启动子在鸡输卵管中特异性表达，重组表达载体包含启动子和用于编码所需蛋白质的所需基因。 输卵管特异性启动子和包含启动子的重组表达载体可以在输卵管中特异性诱导蛋白质的表达，即分泌蛋白质以在卵中大量积聚的器官。 因此，本发明的输卵管特异性启动子和重组表达载体可以有利地用于产生转化的鸡，其可以大量产生高附加值的有用元件，产生功能性蛋，并且改善家禽的经济性状。

公开(公告)号：US20100167343A1

公开(公告)日：2010-07-01

申请号：US12514730

申请日：2007-11-15

申请人： Tae Yoon Kim ,  Sang Hoon Kim ,  Ik Soo Jeon ,  Sung Jun Byun ,  Dong Heon Shin ,  Nam Soo Kim

发明人： Tae Yoon Kim ,  Sang Hoon Kim ,  Ik Soo Jeon ,  Sung Jun Byun ,  Dong Heon Shin ,  Nam Soo Kim

IPC分类号： C12P21/00 ,  C07H21/04 ,  C12N15/74 ,  C12N5/071

CPC分类号： C07K14/465 ,  C12N15/85 ,  C12N2830/008 ,  C12N2830/90

摘要： An oviduct specific expression promoter and a recombinant expression vector including the same. A promoter of an AGR2 gene is expressed specifically in the chicken oviduct, and a recombinant expression vector includes the promoter and a desired gene for encoding a desired protein. The oviduct specific promoter and the recombinant expression vector including the promoter can induce the expression of a protein specifically in the oviduct, i.e., an organ that secrets proteins so as to accumulate with a large amount in the egg. Accordingly, the oviduct specific promoter and the recombinant expression vector of the present invention can be advantageously used to produce transformed chickens, which can massively yield useful elements of high added value, produce functional eggs, and improve the economic traits of the poultry.

摘要翻译： 输卵管特异性表达启动子和包含其的重组表达载体。 AGR2基因的启动子在鸡输卵管中特异性表达，重组表达载体包含启动子和用于编码所需蛋白质的所需基因。 输卵管特异性启动子和包含启动子的重组表达载体可以在输卵管中特异性诱导蛋白质的表达，即分泌蛋白质以在卵中大量积聚的器官。 因此，本发明的输卵管特异性启动子和重组表达载体可以有利地用于产生转化的鸡，其可以大量产生高附加值的有用元件，产生功能性蛋，并且改善家禽的经济性状。