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公开(公告)号:US06936633B2
公开(公告)日:2005-08-30
申请号:US10750247
申请日:2003-12-31
申请人: Dong Zou , Olivier Dasse , Janelle Evans , Paul Higgins , Jeremy Kintigh , Rama Kondru , Eric Schwartz , Laurent Knerr , Hai-Xiao Zhai
发明人: Dong Zou , Olivier Dasse , Janelle Evans , Paul Higgins , Jeremy Kintigh , Rama Kondru , Eric Schwartz , Laurent Knerr , Hai-Xiao Zhai
IPC分类号: A61K31/40 , A61K31/4015 , A61K31/402 , A61K31/4025 , A61K31/422 , A61K31/4439 , A61P1/04 , A61P1/16 , A61P7/02 , A61P9/10 , A61P9/14 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/04 , A61P17/06 , A61P19/02 , A61P21/02 , A61P25/00 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/04 , A61P31/18 , A61P35/00 , A61P37/02 , A61P37/08 , A61P39/02 , C07D207/24 , C07D207/26 , C07D207/273 , C07D207/36 , C07D207/38 , C07D401/04 , C07D405/04 , C07D405/08 , C07D409/04 , C07D409/06 , C07D413/06 , C07D207/04
CPC分类号: C07D207/273 , A61K31/4015 , A61K31/4439 , C07D207/24 , C07D207/36 , C07D401/04 , C07D405/04 , C07D409/04 , C07D409/06 , C07D413/06
摘要: The present invention provides pharmaceutical compositions and novel compounds useful in the treatment of conditions mediated by CCR2, MCP-1 or the interaction thereof. The compounds of the present invention are pyrrolidinones and pyrrolidine-thiones.
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公开(公告)号:US20050004180A1
公开(公告)日:2005-01-06
申请号:US10489661
申请日:2002-09-26
申请人: Dong Zou , Olivier Dasse , Janelle Evans , Paul Higgins , Jeremy Kintigh , Laurent Knerr , Rama Kondru , Eric Schwartz , Hai-Xiao Zhai
发明人: Dong Zou , Olivier Dasse , Janelle Evans , Paul Higgins , Jeremy Kintigh , Laurent Knerr , Rama Kondru , Eric Schwartz , Hai-Xiao Zhai
IPC分类号: A61K31/40 , A61K31/4015 , A61K31/402 , A61K31/4025 , A61K31/422 , A61K31/4439 , A61P1/04 , A61P1/16 , A61P7/02 , A61P9/10 , A61P9/14 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/04 , A61P17/06 , A61P19/02 , A61P21/02 , A61P25/00 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/04 , A61P31/18 , A61P35/00 , A61P37/02 , A61P37/08 , A61P39/02 , C07D207/24 , C07D207/26 , C07D207/273 , C07D207/36 , C07D207/38 , C07D401/04 , C07D405/04 , C07D405/08 , C07D409/04 , C07D409/06 , C07D413/06
CPC分类号: C07D207/273 , A61K31/4015 , A61K31/4439 , C07D207/24 , C07D207/36 , C07D401/04 , C07D405/04 , C07D409/04 , C07D409/06 , C07D413/06
摘要: The present invention provides pharmaceutical compositions and novel compounds useful in the treatment of conditions mediated by CCR2, MCP-1 or the interaction thereof. The compounds of the present invention are pyrrolidinones and pyrrolidine-thiones.
摘要翻译: 本发明提供了用于治疗由CCR2,MCP-1介导的病症或其相互作用的药物组合物和新化合物。 本发明的化合物是吡咯烷酮和吡咯烷 - 硫堇。
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公开(公告)号:US06727275B2
公开(公告)日:2004-04-27
申请号:US10255494
申请日:2002-09-26
申请人: Dong Zou , Olivier Dasse , Janelle Evans , Paul Higgins , Jeremy Kintigh , Rama Kondru , Eric Schwartz , Laurent Knerr , Hai-Xiao Zhai
发明人: Dong Zou , Olivier Dasse , Janelle Evans , Paul Higgins , Jeremy Kintigh , Rama Kondru , Eric Schwartz , Laurent Knerr , Hai-Xiao Zhai
IPC分类号: C07D20726
CPC分类号: C07D207/273 , A61K31/4015 , A61K31/4439 , C07D207/24 , C07D207/36 , C07D401/04 , C07D405/04 , C07D409/04 , C07D409/06 , C07D413/06
摘要: The present invention provides pharmaceutical compositions and novel compounds useful in the treatment of conditions mediated by CCR2, MCP-1 or the interaction thereof. The compounds of the present invention are pyrrolidinones and pyrrolidine-thiones.
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