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    OSTEO OR TISSUE HEALING KIT AND METHOD OF USING THE SAME
    2.
    发明申请
    OSTEO OR TISSUE HEALING KIT AND METHOD OF USING THE SAME 审中-公开
    OSTEO或组织治疗套件及其使用方法

    公开(公告)号：US20090082613A1

    公开(公告)日：2009-03-26

    申请号：US11859991

    申请日：2007-09-24

    申请人： Robert G. DENNIS ,  David A. WOLF ,  Donnie RUDD

    发明人： Robert G. DENNIS ,  David A. WOLF ,  Donnie RUDD

    IPC分类号： A61N2/02 ,  A61K35/12

    CPC分类号： A61N2/02

    摘要： An osteo or tissue healing kit and method of promoting the healing of compromised bone or tissue in a living mammal. The osteo or tissue healing device of the kit includes a magnetic field emitter and a controlling circuit, and at least one stem cell. The method of using the osteo or tissue healing kit includes placing at least one stem cell within the compromised bone or tissue and applying a time variant magnetic field.

    摘要翻译： 一种骨骼或组织愈合试剂盒和促进活的哺乳动物中受损的骨骼或组织的愈合的方法。 该套件的骨组织愈合装置包括磁场发射器和控制电路以及至少一个干细胞。 使用骨或组织愈合试剂盒的方法包括将至少一个干细胞置于受损骨或组织内并应用时变磁场。

    METHOD OF PROVIDING READILY AVAILABLE CELLULAR MATERIAL DERIVED FROM CORD BLOOD, AND A COMPOSITION THEREOF
    3.
    发明申请
    METHOD OF PROVIDING READILY AVAILABLE CELLULAR MATERIAL DERIVED FROM CORD BLOOD, AND A COMPOSITION THEREOF 审中-公开
    提供从盘状血液中提取的可用的可用细胞材料的方法及其组合物

    公开(公告)号：US20080057042A1

    公开(公告)日：2008-03-06

    申请号：US11832145

    申请日：2007-08-01

    申请人： Donnie RUDD

    发明人： Donnie RUDD

    IPC分类号： A61K35/00 ,  A01N1/02 ,  A61P43/00 ,  C12N5/06

    CPC分类号： C12N5/0647 ,  A01N1/02 ,  A01N1/0221 ,  A01N1/0294 ,  A61K2035/124

    摘要： The present invention is directed to the TVEMF-expansion of mammalian cord blood stem cells in a rotating TVEMF-bioreactor, to compositions resulting from the TVEMF-expanded cells, and to a method of treating disease or repairing tissue with the compositions. Various benefits and advantages to the compositions of the present invention are discussed herein.

    摘要翻译： 本发明涉及在旋转的TVEMF生物反应器中的哺乳动物脐带血干细胞的TVEMF扩增，由TVEMF扩增的细胞产生的组合物，以及用该组合物治疗疾病或修复组织的方法。 本文讨论了本发明组合物的各种益处和优点。

    OSTEO OR TISSUE HEALING DEVICE, KIT AND METHOD OF USING THE SAME
    4.
    发明申请
    OSTEO OR TISSUE HEALING DEVICE, KIT AND METHOD OF USING THE SAME 审中-公开
    OSTEO或组织治疗装置，套件及其使用方法

    公开(公告)号：US20090082610A1

    公开(公告)日：2009-03-26

    申请号：US11859939

    申请日：2007-09-24

    申请人： David A. WOLF ,  Robert G. DENNIS ,  Donnie RUDD

    发明人： David A. WOLF ,  Robert G. DENNIS ,  Donnie RUDD

    IPC分类号： A61N2/00

    CPC分类号： A61N2/02 ,  A61N1/326

    摘要： An osteo or tissue healing device, kit and method of using the device to promote healing of compromised bone or tissue in a living mammal is disclosed. The osteo or tissue healing device includes a magnetic field emitter and a controlling circuit. The magnetic field emitter of the device is electrically coupled to a controlling circuit in which the magnetic field emitter is configured to provide a time variant magnetic field when driven by an electric pulse train from the controlling circuit in such a manner that the time variant magnetic field results in a magnetic (B) field exhibiting a magnetic slew rate of at least about 10 kiloGauss/sec. The controlling circuit of the device is electrically coupled to the magnetic field emitter and is configured to be powered by a power source, in which the controlling circuit is configured to output the electric pulse train driving the magnetic field emitter. It is thought that the steep magnetic field pulses and the relatively long inactive periods play important roles in promoting bone or tissue healing processes. The kit includes the unassembled components of the device. The method of using the osteo or tissue healing device includes the step of applying a time variant magnetic field to bone or tissue to promote healing of the bone or tissue.

    摘要翻译： 公开了一种使用该装置促进活的哺乳动物中受损的骨骼或组织的愈合的骨或组织愈合装置，试剂盒和方法。 骨或组织愈合装置包括磁场发射器和控制电路。 器件的磁场发射极电耦合到控制电路，其中磁场发射器被配置为当由来自控制电路的电脉冲串驱动时提供时变磁场，使得时变磁场 导致表现出至少约10千高斯/秒的磁压摆率的磁（B）场。 该装置的控制电路电耦合到磁场发射器，并且被配置为由电源供电，其中控制电路被配置为输出驱动磁场发射器的电脉冲串。 据认为，陡峭的磁场脉冲和较长的非活动期在促进骨骼或组织愈合过程中起重要作用。 该套件包括设备的未组装组件。 使用骨或组织愈合装置的方法包括将时变磁场施加到骨骼或组织以促进骨骼或组织愈合的步骤。

    METHOD OF CHARACTERIZING A BIOLOGICALLY ACTIVE COMPOUND
    5.
    发明申请
    METHOD OF CHARACTERIZING A BIOLOGICALLY ACTIVE COMPOUND 审中-公开
    表征生物活性化合物的方法

    公开(公告)号：US20070190520A1

    公开(公告)日：2007-08-16

    申请号：US11669637

    申请日：2007-01-31

    申请人： David WOLF ,  Donnie RUDD

    发明人： David WOLF ,  Donnie RUDD

    IPC分类号： C12Q1/70 ,  C12Q1/68 ,  C12Q1/00

    CPC分类号： G01N33/5008 ,  C12M27/10 ,  C12M35/02 ,  C12Q1/025 ,  G01N33/502 ,  G01N33/5073

    摘要： A method of characterizing a biologically active compound by placing a cell mixture into a rotatable bioreactor to initiate a three-dimensional culture comprising a biological component and at least one cell, controllably expanding the cells in the rotatable bioreactor and testing the biological component to characterize the biologically active compound. The present invention may also preferably comprise exposing the cells to a time varying electromagnetic force.

    摘要翻译： 通过将细胞混合物放置在可旋转的生物反应器中以引发包括生物成分和至少一个细胞的三维培养物来表征生物活性化合物的方法，可控地扩展可旋转的生物反应器中的细胞并测试生物学组分以表征 生物活性化合物。 本发明还可以优选地包括将电池暴露于时变电磁力。

    BIOREACTOR, KIT AND METHOD OF USING SAME
    7.
    发明申请
    BIOREACTOR, KIT AND METHOD OF USING SAME 审中-公开
    生物反应器，套件及其使用方法

    公开(公告)号：US20090081752A1

    公开(公告)日：2009-03-26

    申请号：US11859976

    申请日：2007-09-24

    申请人： Robert G. DENNIS ,  David A. WOLF ,  Donnie RUDD

    发明人： Robert G. DENNIS ,  David A. WOLF ,  Donnie RUDD

    IPC分类号： C12N13/00 ,  C12M1/10 ,  C12M1/42

    CPC分类号： C12N5/0634 ,  A61K2035/124 ,  C12N2525/00

    摘要： A bioreactor, kit, a method of using the device to promoting growing and/or culture of a cell, and a method for regenerating and/or improving the function of mammalian cells. The bioreactor includes a controlling circuit coupled to magnetic field emitter that emits relatively steep and short-lived magnetic field pulses during these an active ephemeral period. The bioreactor also provides a relatively long-term inactive phase in which no magnetic field pulses are imposed. The kit includes the unassembled components of the bioreactor. The method of using the bioreactor and of regenerating and/or improving the function of mammalian cells includes the step of applying a time variant magnetic field through the cell to promote growing and/or culturing, and then introducing the cells to a mammal to regenerate cells.

    摘要翻译： 生物反应器，试剂盒，使用该装置促进细胞生长和/或培养的方法，以及用于再生和/或改善哺乳动物细胞功能的方法。 生物反应器包括耦合到磁场发射器的控制电路，其在这些活跃的短暂时段期间发射相对陡峭和短寿命的磁场脉冲。 生物反应器还提供了不施加磁场脉冲的相对长期的非活性阶段。 试剂盒包括生物反应器的未组装的组分。 使用生物反应器和再生和/或改善哺乳动物细胞功能的方法包括将时变磁场通过细胞以促进生长和/或培养，然后将细胞引入哺乳动物以再生细胞的步骤 。

    METHOD OF REPLENISHING CELLS DAMAGED BY TREATMENT FOR CANCER
    8.
    发明申请
    METHOD OF REPLENISHING CELLS DAMAGED BY TREATMENT FOR CANCER 审中-公开
    通过治疗癌症来破坏细胞的方法

    公开(公告)号：US20070172466A1

    公开(公告)日：2007-07-26

    申请号：US11614345

    申请日：2006-12-21

    申请人： Donnie RUDD

    发明人： Donnie RUDD

    IPC分类号： A61K48/00 ,  A61K35/14 ,  C12N5/08

    CPC分类号： C12N5/0634 ,  A61K2035/124 ,  C12N2501/125 ,  C12N2501/22

    摘要： A method of replenishing cells damaged by treatment for cancer comprising removing a sample of peripheral blood containing CD34+ pluripotent adult stem cells from a primate mammal, controllably expanding the cells without differentiation at a rate which produces an expansion factor of at least seven times within seven days while maintaining their three-dimensional geometry and their cell-to-cell support and cell-to-cell geometry, removing any toxic materials from the expanded undifferentiated CD34+ pluripotent adult stem cells, and reintroducing the CD34+ pluripotent adult stem cells into the primate mammal within a time period sufficient to prevent the primate mammal from suffering decreased mobility due to loss of hematopoietic or other cells from a treatment for cancer.

    摘要翻译： 一种补充由癌症治疗损伤的细胞的方法，包括从灵长类哺乳动物中除去含有CD34 +多能成体干细胞的外周血样品，可以在7天内产生扩增因子至少7倍的速率可控扩张细胞而不分化 同时保持其三维几何形状及其细胞间细胞支持和细胞间细胞几何形状，从扩增的未分化CD34 +多能成体干细胞中除去任何有毒物质，并将CD34 +多能成体干细胞重新引入到灵长类哺乳动物内 足以防止灵长类哺乳动物因癌症治疗造成造血细胞或其他细胞损失而导致移动性降低的时间。