公开(公告)号：US20050163914A1

公开(公告)日：2005-07-28

申请号：US10507924

申请日：2003-03-17

申请人： Doris Klee ,  Norbert Weiss ,  Alexander Rubben ,  Arno Bucker

发明人： Doris Klee ,  Norbert Weiss ,  Alexander Rubben ,  Arno Bucker

IPC分类号： A61K47/48 ,  A61L31/16 ,  A61L2/00 ,  B05D3/00

CPC分类号： A61L31/16 ,  A61K47/6957 ,  A61L2300/428 ,  A61L2300/602 ,  A61L2300/608

摘要： The present invention describes a deposition method for applying an active ingredient onto an endoprosthesis with a thin polymer coating. By means of the inventive deposition method which can be carried out in a technically easy way it is possible to bring about a slow and largely constant active ingredient release, as shown in III. 1 using tretinoin as the example. Since further processing steps are not necessary after the application of the active ingredient(s), no destruction of the active ingredient by the application of a second polymer coating, for example, has to be feared. Thus, relatively unstable active ingredients, such as tretinoin, can also be applied onto the endoprosthesis without any problems.

摘要翻译： 本发明描述了一种使用薄聚合物涂层将活性成分施用到内用假体上的沉积方法。 通过本发明的沉积方法，其可以以技术上容易的方式进行，如III所示，可以产生缓慢且大部分恒定的活性成分释放。 1以维甲酸为例。 由于在施用活性成分之后不需要进一步的加工步骤，所以不必担心例如通过施加第二聚合物涂层破坏活性成分。 因此，相对不稳定的活性成分（如维甲酸）也可以应用于内用假体，没有任何问题。

公开(公告)号：US20080243244A1

公开(公告)日：2008-10-02

申请号：US12035699

申请日：2008-02-22

申请人： Arno Bucker ,  Alexander Rubben

发明人： Arno Bucker ,  Alexander Rubben

IPC分类号： A61F2/06

CPC分类号： A61F2/82 ,  A61F2/88 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/9155 ,  A61F2220/005 ,  A61F2220/0058 ,  A61L31/022 ,  A61L31/18

摘要： A metallic endoprosthesis is provided and causes no significant artefacts on images taken by magnetic resonance tomography (MRT), as a result of the combination of the production materials with a special design, which permits an evaluation of the externally adjacent region and the lumen of the endoprosthesis by means of MRT. The endoprosthesis is made from a material with a magnetisability similar to human tissue. The design of the endoprosthesis is such that the members or wires of the endoprosthesis run extensively along the longitudinal axis of the endoprosthesis, without forming a closed circuit in a plane which is essentially perpendicular to the endoprosthesis longitudinal axis. Further variations of the endoprosthesis design are possible, which all offer a full compatibility with MR for the endoprosthesis

摘要翻译： 由于生产材料与特殊设计的结合，提供了一种金属内置假体，并且不会对由磁共振断层扫描（MRT）拍摄的图像产生显着的伪像，这样可以评估外部相邻区域和 通过MRT进行内假体。 内置假体由具有类似于人体组织的可磁性的材料制成。 内假体的设计使得内用假体的构件或电线沿着内置假体的纵向轴线延伸，而不在基本上垂直于内假体纵向轴线的平面中形成闭合电路。 内置假体设计的进一步变化是可能的，所有这些都能为内置假体提供与MR的完全兼容性

公开(公告)号：US20090227892A1

公开(公告)日：2009-09-10

申请号：US12300418

申请日：2006-05-11

申请人： Gabriele Krombach ,  Arno Bucker ,  Joachim G. Pfeffer ,  Michael Friebe

发明人： Gabriele Krombach ,  Arno Bucker ,  Joachim G. Pfeffer ,  Michael Friebe

IPC分类号： A61M25/00 ,  A61B10/06 ,  A61B18/18

CPC分类号： A61M25/0084

摘要： The invention relates to a catheter device (1) for percutaneous interventions, in particular for injections, biopsies or the like, with an outer catheter (2) and with a tool for the intervention, in particular an injection needle (3), biopsy forceps, electrodes or the like, at the proximal end (4) of the catheter device (1). To be able to perform a percutaneous intervention free of injury, the tool is received in the outer catheter (2) in the delivery state, and the tip of the tool is recessed in the outer catheter (2) in the delivery state or aligned with the proximal end of the outer catheter (2), and the tool can be moved relative to the outer catheter (2) in such a way that at least the tip of the tool protrudes past the proximal end (4) of the outer catheter (2) in the state of engagement.

摘要翻译： 本发明涉及一种用于经皮干预的导管装置（1），特别是用于注射，活组织检查等，具有外导管（2）和用于介入的工具，特别是注射针（3），活检钳 ，电极或类似物，在导管装置（1）的近端（4）处。 为了能够执行没有受伤的经皮干预，该工具在输送状态下被容纳在外导管（2）中，并且工具的尖端在输送状态下凹入外导管（2）或与 外导管（2）的近端，并且工具可以相对于外导管（2）移动，使得至少刀具的尖端突出超过外导管的近端（4） 2）在接触状态。