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公开(公告)号:US07705195B2
公开(公告)日:2010-04-27
申请号:US10516868
申请日:2003-06-04
IPC分类号: G91N33/00 , A01K67/00 , A01K67/033 , A01K67/027 , C12N15/00 , C12N5/00 , C12N15/63 , A01N43/04 , A61K31/70
CPC分类号: G01N33/57438 , C07K14/50 , G01N2500/04
摘要: The present invention is directed to methods using transgenic mice to screen for biologically active agents.
摘要翻译: 本发明涉及使用转基因小鼠筛选生物活性剂的方法。
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公开(公告)号:US08409579B2
公开(公告)日:2013-04-02
申请号:US13539151
申请日:2012-06-29
申请人: Mark Dennis , Luc Desnoyers , Dorothy French
发明人: Mark Dennis , Luc Desnoyers , Dorothy French
IPC分类号: A61K39/395 , C07K16/22 , C07K14/50
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要: The present invention concerns antagonists of the FGF19/FGFR4 pathways, and the uses of same.
摘要翻译: 本发明涉及FGF19 / FGFR4途径的拮抗剂及其用途。
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公开(公告)号:US20120263717A1
公开(公告)日:2012-10-18
申请号:US13539151
申请日:2012-06-29
申请人: Mark Dennis , Luc Desnoyers , Dorothy French
发明人: Mark Dennis , Luc Desnoyers , Dorothy French
IPC分类号: A61K39/395 , A61P35/04
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要: The present invention concerns antagonists of the FGF19/FGFR4 pathways, and the uses of same.
摘要翻译: 本发明涉及FGF19 / FGFR4途径的拮抗剂及其用途。
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公开(公告)号:US20120128675A1
公开(公告)日:2012-05-24
申请号:US13315220
申请日:2011-12-08
申请人: Luc DESNOYERS , Dorothy French
发明人: Luc DESNOYERS , Dorothy French
IPC分类号: A61K39/395 , A61P1/16 , A61P1/00 , A61K35/00
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S435/81
摘要: The invention provides anti-FGF19 antibodies, and compositions comprising and methods of using these antibodies, methods using anti-FGF19 antibodies, and methods comprising detection of FGF19 and/or FGFR4.
摘要翻译: 本发明提供了抗FGF19抗体,组合物和使用这些抗体的方法,使用抗FGF19抗体的方法,以及包括检测FGF19和/或FGFR4的方法。
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公开(公告)号:US20100129381A1
公开(公告)日:2010-05-27
申请号:US12692468
申请日:2010-01-22
申请人: Luc DESNOYERS , Dorothy French
发明人: Luc DESNOYERS , Dorothy French
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S435/81
摘要: The invention provides anti-FGF19 antibodies, and compositions comprising and methods of using these antibodies, methods using anti-FGF19 antibodies, and methods comprising detection of FGF19 and/or FGFR4.
摘要翻译: 本发明提供了抗FGF19抗体,组合物和使用这些抗体的方法,使用抗FGF19抗体的方法,以及包括检测FGF19和/或FGFR4的方法。
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公开(公告)号:US08241633B2
公开(公告)日:2012-08-14
申请号:US12913660
申请日:2010-10-27
申请人: Luc Desnoyers , Dorothy French
发明人: Luc Desnoyers , Dorothy French
IPC分类号: A61K39/395
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S435/81
摘要: The invention provides anti-FGF19 antibodies, and compositions comprising and methods of using these antibodies, methods using anti-FGF19 antibodies, and methods comprising detection of FGF19 and/or FGFR4.
摘要翻译: 本发明提供了抗FGF19抗体,组合物和使用这些抗体的方法,使用抗FGF19抗体的方法,以及包括检测FGF19和/或FGFR4的方法。
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公开(公告)号:US20070143871A1
公开(公告)日:2007-06-21
申请号:US11556803
申请日:2006-11-06
IPC分类号: A01K67/027 , C12N5/06
CPC分类号: G01N33/57438 , C07K14/50 , G01N2500/04
摘要: The invention relates to the field of non-human, transgenic animal models for hepatocellular carcinoma.
摘要翻译: 本发明涉及用于肝细胞癌的非人类,转基因动物模型的领域。
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公开(公告)号:US07846691B2
公开(公告)日:2010-12-07
申请号:US12692468
申请日:2010-01-22
申请人: Luc Desnoyers , Dorothy French
发明人: Luc Desnoyers , Dorothy French
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S435/81
摘要: The invention provides anti-FGF19 antibodies, and compositions comprising and methods of using these antibodies, methods using anti-FGF19 antibodies, and methods comprising detection of FGF19 and/or FGFR4.
摘要翻译: 本发明提供了抗FGF19抗体,组合物和使用这些抗体的方法,使用抗FGF19抗体的方法,以及包括检测FGF19和/或FGFR4的方法。
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公开(公告)号:US20070248604A1
公开(公告)日:2007-10-25
申请号:US11673411
申请日:2007-02-09
申请人: Luc Desnoyers , Dorothy French
发明人: Luc Desnoyers , Dorothy French
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S435/81
摘要: The invention provides anti-FGF19 antibodies, and compositions comprising and methods of using these antibodies, methods using anti-FGF19 antibodies, and methods comprising detection of FGF19 and/or FGFR4.
摘要翻译: 本发明提供了抗FGF19抗体,组合物和使用这些抗体的方法,使用抗FGF19抗体的方法,以及包括检测FGF19和/或FGFR4的方法。
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公开(公告)号:US20050166274A1
公开(公告)日:2005-07-28
申请号:US10516868
申请日:2003-06-04
IPC分类号: A01K67/027 , A61K31/7088 , A61K35/12 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/00 , A61P1/16 , A61P1/18 , A61P11/00 , A61P13/10 , A61P15/00 , A61P17/00 , A61P25/00 , A61P35/00 , A61P35/02 , C07K14/00 , C07K14/47 , C07K14/50 , C07K16/18 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/574 , C12N5/06
CPC分类号: G01N33/57438 , C07K14/50 , G01N2500/04
摘要: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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