公开(公告)号：US20120021925A1

公开(公告)日：2012-01-26

申请号：US13144662

申请日：2010-01-19

申请人： Katrin Atnikov ,  Douglas Barker ,  Yilan Zhang ,  Stephen Frost

发明人： Katrin Atnikov ,  Douglas Barker ,  Yilan Zhang ,  Stephen Frost

IPC分类号： C40B30/00 ,  H01J49/40 ,  C12Q1/37 ,  H01J49/26 ,  G01N33/577 ,  G01N21/64

CPC分类号： G01N33/57434 ,  G01N1/405 ,  G01N2333/96455 ,  G01N2800/56

摘要： The application refers to a method for diagnosing prostate cancer through the measurement of the combination of PSP94 (β-microseminoprotein) and F/T PSA biomarkers, the method using urine samples to measure PSP94 and serum samples to analyse F/T PSA. In one embodiment, the PSP94 is standardized to creatinine. Also based on the measurement of PSP94 and F/T PSA are provided methods and kits for (a) diagnosing aggressive prostate cancer; (b) differential diagnosis; and (c) diagnosing the progression of prostate cancer.

摘要翻译： 该应用是指通过测量PSP94（＆bgr。-microseminoprotein）和F / T PSA生物标志物的组合来诊断前列腺癌的方法，该方法使用尿液样品测量PSP94和血清样品以分析F / T PSA。 在一个实施方案中，PSP94被标准化为肌酸酐。 还基于PSP94和F / T PSA的测量提供了用于（a）诊断侵袭性前列腺癌的方法和试剂盒; （b）鉴别诊断; 和（c）诊断前列腺癌的进展。

公开(公告)号：US20130323253A1

公开(公告)日：2013-12-05

申请号：US13701299

申请日：2011-06-01

申请人： Douglas Barker ,  Katrin Atnikov ,  Yilan Zhang ,  Stephen Frost

发明人： Douglas Barker ,  Katrin Atnikov ,  Yilan Zhang ,  Stephen Frost

IPC分类号： G01N33/574 ,  A61K39/395 ,  A61K39/00

CPC分类号： G01N33/57419 ,  A61K38/00 ,  A61K39/0011 ,  A61K39/3955 ,  C07K16/28 ,  G01N2800/56

摘要： The present invention relates to the field of the diagnosis of large intestine/colon diseases. More particularly, the present invention provides a method for differential diagnosis of colorectal cancer from a non-malignant disease of the large intestine/colon, and from a healthy large intestine/colon. The invention also relates to treatment of colorectal cancer.

摘要翻译： 本发明涉及大肠/结肠疾病的诊断领域。 更具体地，本发明提供了从大肠/结肠的非恶性疾病和健康的大肠/结肠的结直肠癌的鉴别诊断方法。 本发明还涉及结肠直肠癌的治疗。

公开(公告)号：US20100216654A1

公开(公告)日：2010-08-26

申请号：US12531018

申请日：2008-03-12

申请人： Katrin Stedronsky ,  Douglas Barker ,  Yilan Zhang

发明人： Katrin Stedronsky ,  Douglas Barker ,  Yilan Zhang

IPC分类号： C40B30/02

CPC分类号： G01N33/57434 ,  C12Q1/6886 ,  G01N2500/10

摘要： The present invention includes biomolecules and use of these biomolecules for differential diagnosis of prostate cancer and/or non-malignant disease of the prostate. In an embodiment, the present invention provides methods for detecting biomolecules within a biological sample as well as a database comprising of mass profiles of biomolecules specific for healthy subjects, subjects having a non-malignant disease of the prostate and subjects having prostate cancer. The invention further includes kits for differential diagnosis of prostate cancer and/or non-malignant disease of the prostate in a biological sample.

摘要翻译： 本发明包括生物分子和这些生物分子用于鉴别前列腺癌和/或前列腺非恶性疾病的鉴别诊断。 在一个实施方案中，本发明提供了用于检测生物样品内的生物分子的方法，以及包含对健康受试者，具有前列腺非恶性疾病的受试者和具有前列腺癌的受试者的生物分子的质量分布的数据库。 本发明还包括用于生物样品中前列腺癌和/或前列腺非恶性疾病的鉴别诊断的试剂盒。

公开(公告)号：US20080020940A1

公开(公告)日：2008-01-24

申请号：US11782368

申请日：2007-07-24

申请人： Katrin Stedronsky ,  Douglas Barker ,  Yilan Zhang

发明人： Katrin Stedronsky ,  Douglas Barker ,  Yilan Zhang

IPC分类号： C40B30/04 ,  C40B40/04

CPC分类号： G01N33/57419 ,  A61K38/4833 ,  G01N27/447 ,  G01N30/7233 ,  G01N33/6848 ,  G01N2030/027

摘要： The present invention relates to the field of the diagnosis of large intestine diseases. More particularly, embodiments of the invention provide a method for differential diagnosis of colorectal cancer from a non-malignant disease of the large intestine, and from a healthy large intestine.

摘要翻译： 本发明涉及大肠疾病诊断领域。 更具体地，本发明的实施方案提供了一种用于从大肠的非恶性疾病和健康的大肠进行结肠直肠癌的鉴别诊断的方法。

公开(公告)号：US20050283936A1

公开(公告)日：2005-12-29

申请号：US10877252

申请日：2004-06-25

申请人： Douglas Barker ,  Charles Lang ,  Gregg McAllise

发明人： Douglas Barker ,  Charles Lang ,  Gregg McAllise

IPC分类号： A47L11/30 ,  A47L11/34

CPC分类号： A47L11/4091 ,  A47L11/34

摘要： A cleaning apparatus for cleaning a surface in which cleaning solution is dispensed to the surface and substantially simultaneously extracted along with the dirt on the surface in a continuous operation is provided. The cleaning apparatus includes a housing and a recovery tank removably mounted to the housing. A liquid distribution system is operatively associated with the housing for distributing the cleaning solution to the surface. A suction nozzle is secured to the housing and in fluid communication with the recovery tank. A suction source is in fluid communication with the suction nozzle for generating suction to draw dirt and liquid through the suction nozzle and into the recovery tank. The suction nozzle includes a front nozzle portion removably mounted to a rear nozzle portion.

摘要翻译： 提供了一种用于清洁其中清洁溶液被分配到表面并且在连续操作中基本上同时在表面上被污染地提取的表面的清洁装置。 清洁装置包括壳体和可拆卸地安装到壳体的回收罐。 液体分配系统与壳体可操作地相关联，用于将清洁溶液分配到表面。 吸嘴固定到壳体并与回收罐流体连通。 抽吸源与吸嘴流体连通，用于产生吸力，以通过吸嘴吸入污物和液体并进入回收罐。 吸嘴包括可拆卸地安装到后喷嘴部分的前喷嘴部分。

公开(公告)号：US20050015834A1

公开(公告)日：2005-01-20

申请号：US10619840

申请日：2003-07-14

申请人： Douglas Barker

发明人： Douglas Barker

IPC分类号： A01H1/00 ,  A01H5/00 ,  A01H5/10 ,  C12N5/04 ,  C12N15/82 ,  C12N15/87

CPC分类号： A01H5/10

摘要： An inbred corn line, designated SE8505, is disclosed. The invention relates to the seeds of inbred corn line SE8505, to the plants of inbred corn line SE8505 and to methods for producing a corn plant, either inbred or hybrid, by crossing the inbred line SE8505 with itself or another corn line. The invention further relates to methods for producing a corn plant containing in its genetic material one or more transgenes and to the transgenic plants produced by that method and to methods for producing other inbred corn lines derived from the inbred SE8505.

摘要翻译： 公开了一种称为SE8505的近交玉米品系。 本发明涉及近交玉米品系SE8505的种子，近交玉米品系SE8505的植物以及通过将近交系SE8505与其自身或另一种玉米品系相交的近交系或杂种的玉米植物的生产方法。 本发明还涉及用于生产玉米植物的方法，所述玉米植物含有一种或多种转基因的遗传物质和通过该方法产生的转基因植物以及用于生产源自近交SE8505的其他近交玉米品系的方法。