公开(公告)号：US20050090870A1

公开(公告)日：2005-04-28

申请号：US10692647

申请日：2003-10-24

申请人： Douglas Hine ,  Ven Manda ,  John Sommer

发明人： Douglas Hine ,  Ven Manda ,  John Sommer

IPC分类号： A61B5/042 ,  A61B5/0464 ,  A61N1/05 ,  A61N1/365

CPC分类号： A61N1/0587 ,  A61B5/0422 ,  A61B5/0464 ,  A61N1/056 ,  A61N1/36514 ,  A61N2001/0585 ,  G06F19/00

摘要： The present invention provides a method and apparatus for assessing ventricular function on a chronic basis using a plurality of electrodes disposed on or about a left ventricle and/or a right ventricle—and optionally, at least one mechanical or metabolic sensor—all operatively electrically coupled to an implantable medical device. The plurality of electrodes are preferably spaced-apart so that at least one electrode is disposed electrical communication with a discrete volume of ventricular tissue. In one embodiment, the discrete volume of tissue is defined by multiple longitudinal and axial planes as known and used in the medical arts. Thus, according to the present invention, at least one electrode couples to appropriate sensing circuitry and essentially provides a localized electrogram (EGM) that, when compared to other EGMs, provides for configurable, localized delivery of therapeutic pacing stimulus, diverse impedance-sensing vectors, various diagnostic information regarding myocardial function and/or anti-tachycardia pacing.

摘要翻译： 本发明提供一种用于使用设置在左心室和/或右心室上的周围的多个电极以及任选地至少一个机械或代谢传感器来长期地评估心室功能的方法和装置，所述多个电极全部可操作地电耦合 到可植入医疗装置。 多个电极优选间隔开，使得至少一个电极与离散体积的心室组织电连通。 在一个实施例中，组织的离散体积由医学领域中已知和使用的多个纵向和轴向平面限定。 因此，根据本发明，至少一个电极耦合到适当的感测电路并且基本上提供局部电描记图（EGM），其与其他EGM相比，提供治疗起搏刺激的可配置的局部递送，各种阻抗感测向量 ，关于心肌功能和/或抗心动过速起搏的各种诊断信息。

公开(公告)号：US07142919B2

公开(公告)日：2006-11-28

申请号：US10692647

申请日：2003-10-24

申请人： Douglas S. Hine ,  Ven Manda ,  John L. Sommer

发明人： Douglas S. Hine ,  Ven Manda ,  John L. Sommer

IPC分类号： A61N1/18

CPC分类号： A61N1/0587 ,  A61B5/0422 ,  A61B5/0464 ,  A61N1/056 ,  A61N1/36514 ,  A61N2001/0585 ,  G06F19/00

摘要： The present invention provides a method and apparatus for assessing ventricular function on a chronic basis using a plurality of electrodes disposed on or about a left ventricle and/or a right ventricle—and optionally, at least one mechanical or metabolic sensor—all operatively electrically coupled to an implantable medical device. The plurality of electrodes are preferably spaced-apart so that at least one electrode is disposed electrical communication with a discrete volume of ventricular tissue. In one embodiment, the discrete volume of tissue is defined by multiple longitudinal and axial planes as known and used in the medical arts. Thus, according to the present invention, at least one electrode couples to appropriate sensing circuitry and essentially provides a localized electrogram (EGM) that, when compared to other EGMs, provides for configurable, localized delivery of therapeutic pacing stimulus, diverse impedance-sensing vectors, various diagnostic information regarding myocardial function and/or anti-tachycardia pacing.

摘要翻译： 本发明提供一种用于使用设置在左心室和/或右心室上的周围的多个电极以及任选地至少一个机械或代谢传感器来长期地评估心室功能的方法和装置，所述多个电极全部可操作地电耦合 到可植入医疗装置。 多个电极优选间隔开，使得至少一个电极与离散体积的心室组织电连通。 在一个实施例中，组织的离散体积由医学领域中已知和使用的多个纵向和轴向平面限定。 因此，根据本发明，至少一个电极耦合到适当的感测电路并且基本上提供局部电描记图（EGM），其与其他EGM相比，提供治疗起搏刺激的可配置的局部递送，各种阻抗感测向量 ，关于心肌功能和/或抗心动过速起搏的各种诊断信息。

公开(公告)号：US20070073352A1

公开(公告)日：2007-03-29

申请号：US11237177

申请日：2005-09-28

申请人： David Euler ,  Tommy Bennett ,  Ven Manda ,  D. Deno ,  Vincent Splett

发明人： David Euler ,  Tommy Bennett ,  Ven Manda ,  D. Deno ,  Vincent Splett

IPC分类号： A61N1/00

CPC分类号： A61N1/36564 ,  A61B5/02028 ,  A61B5/0215 ,  A61B5/0422 ,  A61B5/7285 ,  A61N1/3627

摘要： A method comprising sensing a blood pressure signal, deriving a hemodynamic measure from the sensed blood pressure signal, adjusting an extra systolic stimulation control parameter in response to the hemodynamic measure, and delivering extra systolic stimulation pulses according to the adjusted control parameter. The sensed blood pressure signal may be a ventricular or arterial blood pressure signal from which an estimated cardiac output, end diastolic pressure, mean pressure or any other hemodynamic measure is derived. Adjusting the extra systolic stimulation control parameter may include adjusting a pacing rate, a pacing interval, an extra systolic stimulation ratio, an extra systolic stimulation interval or enabling or terminating the extra systolic stimulation.

摘要翻译： 一种方法，包括感测血压信号，从感测到的血压信号导出血液动力学测量值，响应于血液动力学测量值调整额外的收缩刺激控制参数，以及根据所调整的控制参数递送额外的收缩刺激脉冲。 所感测的血压信号可以是心室或动脉血压信号，从其导出估计的心输出量，舒张末期压力，平均压力或任何其它血液动力学测量值。 调整额外的收缩刺激控制参数可以包括调整起搏速率，起搏间隔，额外的收缩期刺激比，额外的收缩期刺激间期或启用或终止额外的收缩期刺激。

公开(公告)号：US20050049472A1

公开(公告)日：2005-03-03

申请号：US10652837

申请日：2003-08-29

申请人： Ven Manda ,  Tommy Bennett ,  Zhongping Yang

发明人： Ven Manda ,  Tommy Bennett ,  Zhongping Yang

IPC分类号： A61B5/00 ,  A61N1/365 ,  A61B5/05

CPC分类号： A61B5/14865 ,  A61B5/0031 ,  A61B5/14532 ,  A61N1/36514

摘要： An implantable biosensor system is disclosed for determining levels of cardiac markers in a patient to aid in the diagnosis, determination of the severity and management of cardiovascular diseases. The sensor includes nanowire sensor elements having a biological recognition element attached to a nanowire transducer that specifically binds to the cardiac marker being measured. Each of the sensor elements is associated with a protective member that prevents the sensor element from interacting with the surrounding environment. At a selected time, the protective member may be disabled, thereby allowing the sensor element to begin sensing signals within a living body.

摘要翻译： 公开了一种用于确定患者心脏标志物水平的可植入生物传感器系统，以帮助诊断，确定心血管疾病的严重性和管理。 该传感器包括纳米线传感器元件，其具有连接到纳米线换能器的生物识别元件，该纳米线传感器特异性地结合正被测量的心脏标志物。 每个传感器元件与防止传感器元件与周围环境相互作用的保护构件相关联。 在选择的时间，保护构件可以被禁用，从而允许传感器元件开始感测活体内的信号。

公开(公告)号：US20100056885A1

公开(公告)日：2010-03-04

申请号：US12612133

申请日：2009-11-04

申请人： Ven Manda ,  Tommy D. Bennett ,  Zhongping Yang

发明人： Ven Manda ,  Tommy D. Bennett ,  Zhongping Yang

IPC分类号： A61B5/145

CPC分类号： A61B5/14865 ,  A61B5/0031 ,  A61B5/14532 ,  A61N1/36514

摘要： An implantable biosensor system is disclosed for determining levels of cardiac markers in a patient to aid in the diagnosis, determination of the severity and management of cardiovascular diseases. The sensor includes nanowire sensor elements having a biological recognition element attached to a nanowire transducer that specifically binds to the cardiac marker being measured. Each of the sensor elements is associated with a protective member that prevents the sensor element from interacting with the surrounding environment. At a selected time, the protective member may be disabled, thereby allowing the sensor element to begin sensing signals within a living body.

摘要翻译： 公开了一种用于确定患者心脏标志物水平的可植入生物传感器系统，以帮助诊断，确定心血管疾病的严重性和管理。 该传感器包括纳米线传感器元件，其具有连接到纳米线换能器的生物识别元件，该纳米线传感器特异性地结合正被测量的心脏标志物。 每个传感器元件与防止传感器元件与周围环境相互作用的保护构件相关联。 在选择的时间，保护构件可以被禁用，从而允许传感器元件开始感测活体内的信号。

公开(公告)号：US07632234B2

公开(公告)日：2009-12-15

申请号：US10652837

申请日：2003-08-29

申请人： Ven Manda ,  Tommy D. Bennett ,  Zhongping Yang

发明人： Ven Manda ,  Tommy D. Bennett ,  Zhongping Yang

IPC分类号： A61B5/02

CPC分类号： A61B5/14865 ,  A61B5/0031 ,  A61B5/14532 ,  A61N1/36514

摘要： An implantable biosensor system is disclosed for determining levels of cardiac markers in a patient to aid in the diagnosis, determination of the severity and management of cardiovascular diseases. The sensor includes nanowire sensor elements having a biological recognition element attached to a nanowire transducer that specifically binds to the cardiac marker being measured. Each of the sensor elements is associated with a protective member that prevents the sensor element from interacting with the surrounding environment. At a selected time, the protective member may be disabled, thereby allowing the sensor element to begin sensing signals within a living body.

摘要翻译： 公开了一种用于确定患者心脏标志物水平的可植入生物传感器系统，以帮助诊断，确定心血管疾病的严重性和管理。 该传感器包括纳米线传感器元件，其具有连接到纳米线换能器的生物识别元件，该纳米线传感器特异性地结合正被测量的心脏标志物。 每个传感器元件与防止传感器元件与周围环境相互作用的保护构件相关联。 在选择的时间，保护构件可以被禁用，从而允许传感器元件开始感测活体内的信号。