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    Implantable biosensor devices for monitoring cardiac marker molecules
    1.
    发明申请
    Implantable biosensor devices for monitoring cardiac marker molecules 失效
    用于监测心脏标志物分子的可植入生物传感器装置

    公开(公告)号：US20050049472A1

    公开(公告)日：2005-03-03

    申请号：US10652837

    申请日：2003-08-29

    申请人： Ven Manda ,  Tommy Bennett ,  Zhongping Yang

    发明人： Ven Manda ,  Tommy Bennett ,  Zhongping Yang

    IPC分类号： A61B5/00 ,  A61N1/365 ,  A61B5/05

    CPC分类号： A61B5/14865 ,  A61B5/0031 ,  A61B5/14532 ,  A61N1/36514

    摘要： An implantable biosensor system is disclosed for determining levels of cardiac markers in a patient to aid in the diagnosis, determination of the severity and management of cardiovascular diseases. The sensor includes nanowire sensor elements having a biological recognition element attached to a nanowire transducer that specifically binds to the cardiac marker being measured. Each of the sensor elements is associated with a protective member that prevents the sensor element from interacting with the surrounding environment. At a selected time, the protective member may be disabled, thereby allowing the sensor element to begin sensing signals within a living body.

    摘要翻译： 公开了一种用于确定患者心脏标志物水平的可植入生物传感器系统，以帮助诊断，确定心血管疾病的严重性和管理。 该传感器包括纳米线传感器元件，其具有连接到纳米线换能器的生物识别元件，该纳米线传感器特异性地结合正被测量的心脏标志物。 每个传感器元件与防止传感器元件与周围环境相互作用的保护构件相关联。 在选择的时间，保护构件可以被禁用，从而允许传感器元件开始感测活体内的信号。

    IMPLANTABLE BIOSENSOR DEVICES FOR MONITORING CARDIAC MARKER MOLECULES
    2.
    发明申请
    IMPLANTABLE BIOSENSOR DEVICES FOR MONITORING CARDIAC MARKER MOLECULES 审中-公开
    用于监测心脏标记分子的可植入生物传感器装置

    公开(公告)号：US20100056885A1

    公开(公告)日：2010-03-04

    申请号：US12612133

    申请日：2009-11-04

    申请人： Ven Manda ,  Tommy D. Bennett ,  Zhongping Yang

    发明人： Ven Manda ,  Tommy D. Bennett ,  Zhongping Yang

    IPC分类号： A61B5/145

    CPC分类号： A61B5/14865 ,  A61B5/0031 ,  A61B5/14532 ,  A61N1/36514

    摘要： An implantable biosensor system is disclosed for determining levels of cardiac markers in a patient to aid in the diagnosis, determination of the severity and management of cardiovascular diseases. The sensor includes nanowire sensor elements having a biological recognition element attached to a nanowire transducer that specifically binds to the cardiac marker being measured. Each of the sensor elements is associated with a protective member that prevents the sensor element from interacting with the surrounding environment. At a selected time, the protective member may be disabled, thereby allowing the sensor element to begin sensing signals within a living body.

    摘要翻译： 公开了一种用于确定患者心脏标志物水平的可植入生物传感器系统，以帮助诊断，确定心血管疾病的严重性和管理。 该传感器包括纳米线传感器元件，其具有连接到纳米线换能器的生物识别元件，该纳米线传感器特异性地结合正被测量的心脏标志物。 每个传感器元件与防止传感器元件与周围环境相互作用的保护构件相关联。 在选择的时间，保护构件可以被禁用，从而允许传感器元件开始感测活体内的信号。

    Implantable biosensor devices for monitoring cardiac marker molecules
    3.
    发明授权
    Implantable biosensor devices for monitoring cardiac marker molecules 失效
    用于监测心脏标志物分子的可植入生物传感器装置

    公开(公告)号：US07632234B2

    公开(公告)日：2009-12-15

    申请号：US10652837

    申请日：2003-08-29

    申请人： Ven Manda ,  Tommy D. Bennett ,  Zhongping Yang

    发明人： Ven Manda ,  Tommy D. Bennett ,  Zhongping Yang

    IPC分类号： A61B5/02

    CPC分类号： A61B5/14865 ,  A61B5/0031 ,  A61B5/14532 ,  A61N1/36514

    摘要： An implantable biosensor system is disclosed for determining levels of cardiac markers in a patient to aid in the diagnosis, determination of the severity and management of cardiovascular diseases. The sensor includes nanowire sensor elements having a biological recognition element attached to a nanowire transducer that specifically binds to the cardiac marker being measured. Each of the sensor elements is associated with a protective member that prevents the sensor element from interacting with the surrounding environment. At a selected time, the protective member may be disabled, thereby allowing the sensor element to begin sensing signals within a living body.

    摘要翻译： 公开了一种用于确定患者心脏标志物水平的可植入生物传感器系统，以帮助诊断，确定心血管疾病的严重性和管理。 该传感器包括纳米线传感器元件，其具有连接到纳米线换能器的生物识别元件，该纳米线传感器特异性地结合正被测量的心脏标志物。 每个传感器元件与防止传感器元件与周围环境相互作用的保护构件相关联。 在选择的时间，保护构件可以被禁用，从而允许传感器元件开始感测活体内的信号。

    Conductive therapeutic coating for medical device
    5.
    发明授权
    Conductive therapeutic coating for medical device 有权
    医疗器械导电治疗涂层

    公开(公告)号：US08128953B2

    公开(公告)日：2012-03-06

    申请号：US12183148

    申请日：2008-07-31

    申请人： Zhongping Yang ,  Genevieve Louise Eichenberg Gallagher

    发明人： Zhongping Yang ,  Genevieve Louise Eichenberg Gallagher

    IPC分类号： A61N1/375 ,  A61N1/39

    CPC分类号： A61K31/575 ,  A61K31/695 ,  A61K47/6957 ,  A61N1/375 ,  C07F7/1804

    摘要： An implantable medical device includes a housing and a coating disposed on the housing. The coating includes a conductive carrier and a therapeutic agent, e.g. an anti-infective agent such as silver particles. The conductive carrier can be any suitable conductive material, such as iridium oxide, titanium nitride, diamond-like carbon, graphite, polyaniline, platinum, carbon nanotubes, carbon black, platinum black, or poly 3,4,-ethylenedioxythiophene. Coatings containing iridium oxide and metallic silver particles are effective in inhibiting bacterial growth in vitro.

    摘要翻译： 可植入医疗装置包括壳体和设置在壳体上的涂层。 该涂层包括导电载体和治疗剂，例如。 抗感染剂如银颗粒。 导电载体可以是任何合适的导电材料，例如氧化铱，氮化钛，类金刚石碳，石墨，聚苯胺，铂，碳纳米管，炭黑，铂黑或聚3,4-亚乙基二氧噻吩。 含有氧化铱和金属银颗粒的涂层在体外抑制细菌生长是有效的。

    Implantable medical device having a conformal coating
    7.
    发明授权
    Implantable medical device having a conformal coating 有权
    具有保形涂层的可植入医疗器械

    公开(公告)号：US07801623B2

    公开(公告)日：2010-09-21

    申请号：US11427625

    申请日：2006-06-29

    申请人： Rick D. McVenes ,  Zhongping Yang

    发明人： Rick D. McVenes ,  Zhongping Yang

    IPC分类号： A61N1/05

    CPC分类号： C23C16/45525 ,  A61N1/0551 ,  A61N1/0558 ,  A61N1/056 ,  C23C16/45555

    摘要： A method for manufacturing an implantable electrical medical device includes forming a conductive substrate, placing the conductive substrate in a deposition chamber; and forming a conformal coating over the conductive substrate using atomic layer deposition. In various embodiments, the conformal coating is a conductive coating and in other embodiments the conformal coating is a dielectric coating.

    摘要翻译： 一种用于制造可植入电气医疗装置的方法，包括形成导电基板，将导电基板放置在沉积室中; 以及使用原子层沉积在所述导电基底上形成保形涂层。 在各种实施例中，保形涂层是导电涂层，在其它实施例中，保形涂层是电介质涂层。

    Implantable medical electrode
    9.
    发明申请
    Implantable medical electrode 审中-公开
    可植入医用电极

    公开(公告)号：US20070233217A1

    公开(公告)日：2007-10-04

    申请号：US11395402

    申请日：2006-03-31

    申请人： Zhongping Yang ,  Rick Mcvenes

    发明人： Zhongping Yang ,  Rick Mcvenes

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0565 ,  A61N1/056

    摘要： An implantable medical electrode for use with implantable medical device systems having a base formed of a tungsten alloy. The tungsten alloy electrode may be a lead-based or leadless electrode and may be provided with or without a coating. The tungsten alloy electrode is utilized in an implantable medical device that includes an electrode having a base formed of a tungsten alloy, an electrical contact, and an electronics module adapted to be electrically coupled to the electrode via the electrical contact.

    摘要翻译： 一种用于具有由钨合金形成的基底的可植入医疗装置系统的可植入医用电极。 钨合金电极可以是铅基或无引线电极，并且可以设置有或不具有涂层。 钨合金电极用于可植入医疗装置中，其包括具有由钨合金形成的基底的电极，电触点和适于通过电触点电耦合到电极的电子模块。

    Branched polyethylene oxide terminated biomedical polymers and their use in biomedical devices
    10.
    发明授权
    Branched polyethylene oxide terminated biomedical polymers and their use in biomedical devices 失效
    支化聚环氧乙烷封端的生物医学聚合物及其在生物医学装置中的应用

    公开(公告)号：US06961610B2

    公开(公告)日：2005-11-01

    申请号：US10131440

    申请日：2002-04-25

    申请人： Zhongping Yang ,  Michael J. Ebert ,  James M. Anderson

    发明人： Zhongping Yang ,  Michael J. Ebert ,  James M. Anderson

    IPC分类号： A61L31/00 ,  A61L27/34 ,  A61L27/54 ,  A61N1/02 ,  A61N1/375

    CPC分类号： A61L27/34 ,  A61L27/54 ,  A61L2300/112 ,  A61L2300/204 ,  A61L2300/22 ,  A61L2300/25 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/45 ,  A61L2300/802

    摘要： A biomedical polymer has a substantially linear base polymer; and branched polyethylene oxide covalently bonded to the base polymer as surface active end groups. The branched polyethylene oxide has at least two, more particularly at least four, and still more particularly at least six branches. Suitable base polymers include epoxies, polyurethanes, polyurethane copolymers, fluoropolymers, polyolefins and silicone rubbers. Biologically active agents may be attached to the branched polyethylene oxide. Suitable biologically active agents include microbial peptide agents, detergents, non-steroidal anti-inflammatory drugs, cations, amine-containing organosilicones, diphosphonates, fatty acids, fatty acid salts, heparin and glucocorticosteroids. The biological polymer may be used as a casing for a medical unit of an implantable medical device, such as a pacemaker. In this case, the casing at least partially encloses the medical unit.

    摘要翻译： 生物医学聚合物具有基本线性的基础聚合物; 和作为表面活性端基共价结合到基础聚合物的支化聚环氧乙烷。 支化聚环氧乙烷具有至少两个，更特别是至少四个，更特别是至少六个分支。 合适的基础聚合物包括环氧树脂，聚氨酯，聚氨酯共聚物，含氟聚合物，聚烯烃和硅橡胶。 生物活性剂可以连接到支化聚环氧乙烷上。 合适的生物活性剂包括微生物肽剂，洗涤剂，非甾体抗炎药，阳离子，含胺有机硅氧烷，二膦酸盐，脂肪酸，脂肪酸盐，肝素和糖皮质激素。 生物聚合物可以用作可植入医疗装置（例如起搏器）的医疗单元的壳体。 在这种情况下，壳体至少部分地包围医疗单元。