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公开(公告)号：US06780157B2
公开(公告)日：2004-08-24
申请号：US10174412
申请日：2002-06-18
Applicant: Douglas N. Stephens , Matthew O'Donnell
Inventor： Douglas N. Stephens , Matthew O'Donnell
IPC: A61B814
CPC classification number: B06B1/0633 , A61B8/12 , A61B8/445 , A61B8/4488 , Y10T29/42
Abstract: An ultrasound transducer array (408) includes at least one transducer element (412) having a first (604) and second (606) portions separated by an acoustical discontinuity (520). The first portion (604) has the desired length to form a half-wave k31 resonance, while the second portion (606) has a resonant length for an undesired very low frequency out-of-band k31 resonance. The thickness of the transducer element (412) is designed for k33 half-resonance. Given the design, the transducer element (412) can operate and provide for both forward-looking (514) and side looking (512) elevation apertures. A method is also disclosed for using the disclosed ultrasound transducer (412) in ultrasound imaging.
Abstract translation: 超声换能器阵列（408）包括至少一个换能器元件（412），该换能器元件具有由声学不连续性（520）隔开的第一（604）和第二（606）部分。 第一部分（604）具有期望的长度以形成半波k31谐振，而第二部分（606）具有用于不期望的非常低频带外k31谐振的谐振长度。 换能器元件（412）的厚度被设计用于k33半共振。 考虑到设计，换能器元件（412）可以操作并提供前视（514）和侧视（512）仰角孔。 还公开了在超声成像中使用所公开的超声换能器（412）的方法。
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2.发明授权Method and apparatus for creating a color blood flow image based upon ultrasonic echo signals received by an intravascular ultrasound imaging probe 失效基于由血管内超声成像探头接收的超声波回波信号产生彩色血流图像的方法和装置
公开(公告)号：US5921931A
公开(公告)日：1999-07-13
申请号：US827724
申请日：1997-04-08
Applicant: Matthew O'Donnell , Michael J. Eberle , Douglas N. Stephens , Gerald Litzza , Randy Ziegenbein , David Bleam , Ching-Chen Wu
Inventor： Matthew O'Donnell , Michael J. Eberle , Douglas N. Stephens , Gerald Litzza , Randy Ziegenbein , David Bleam , Ching-Chen Wu
CPC classification number: G01S15/8979 , A61B8/06 , A61B8/13 , G01S7/52026 , G01S7/52071
Abstract: A blood flow detection and imaging method and system is described for displaying images in accordance with signals transmitted from an intravascular ultrasound transducer probe. The image processor includes means for independently designating persistence factors for smoothing calculated speed and power of the dynamic portion of a field of view within a vasculature. Furthermore, the designation of a particular image point within a field of view as a dynamic image point (such as a blood flow region) as opposed to a static image point (such as a tissue region) is determined by averaging signal values for image points proximate to an image point of interest over both time and space.
Abstract translation: 描述了血流检测和成像方法和系统，用于根据从血管内超声换能器探头发送的信号显示图像。 图像处理器包括用于独立地指定持久性因子的装置，用于平滑脉管系统内的视场的动态部分的计算速度和功率。 此外，通过对图像点的信号值进行平均，确定与静态图像点（例如组织区域）相对的作为动态图像点（例如血流区域）的视野内的特定图像点的指定 接近于时间和空间上的图像感兴趣点。
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3.发明授权
公开(公告)号：US5453575A
公开(公告)日：1995-09-26
申请号：US234848
申请日：1994-04-28
Applicant: Matthew O'Donnell , Michael J. Eberle , Douglas N. Stephens , Gerald L. Litzza , Daniel S. Haviland
Inventor： Matthew O'Donnell , Michael J. Eberle , Douglas N. Stephens , Gerald L. Litzza , Daniel S. Haviland
CPC classification number: A61B8/06 , A61B8/12 , A61B8/4483 , A61B8/4488 , A61B8/4494 , B06B1/0633 , B06B1/067 , B06B1/0674 , G01S15/892 , G01S15/8979 , G01S15/899 , G10K11/004 , G10K11/008 , A61B8/445 , B06B2201/76 , G01S15/8981 , Y10T29/42
Abstract: An apparatus and method are described for imaging blood flow from within a vasculature. An ultrasound catheter probe carrying an ultrasound transducer array is inserted within a blood vessel. The transducer array emits ultrasound excitation signals and receives ultrasound echo waveforms reflected from blood and tissue in a region of the vasculature. A series of the echo waveforms resulting from a series of excitation signals are combined in a manner such that the echo signals from static features in the region, such as tissue and plaque, are significantly attenuated. The combined signal primarily represents the relatively dynamic features in the region (i.e. the blood flow). A blood flow image is constructed from the combined signal. The blood flow image is colorized and combined with an image of the relatively static features in the region. Thereafter, the combined image is displayed on a video display.
Abstract translation: 描述了用于对脉管系统内的血流进行成像的装置和方法。 携带超声波换能器阵列的超声波导管探针插入血管内。 换能器阵列发射超声激发信号并且接收从脉管系统区域中的血液和组织反射的超声回波波形。 由一系列激励信号产生的一系列回波波形以这样的方式组合，使得来自该区域中的静态特征（例如组织和斑块）的回波信号被显着衰减。 组合信号主要表示该区域中相对动态的特征（即，血流）。 血液流动图像由组合信号构成。 血流图像被着色并与该区域中相对静态特征的图像组合。 此后，组合的图像显示在视频显示器上。
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4.发明授权Method and apparatus for delivering therapy in and association with an intravascular ultrasound device 有权用于在血管内超声装置中进行治疗并与其结合的方法和装置公开(公告)号：US07736317B2
公开(公告)日：2010-06-15
申请号：US10243823
申请日：2002-09-13
Applicant: Douglas N. Stephens , Matthew O'Donnell
Inventor： Douglas N. Stephens , Matthew O'Donnell
IPC: A61B8/12
CPC classification number: B06B1/0633 , A61B8/12 , A61B8/445 , A61B8/4488 , Y10T29/42
Abstract: An ultrasound transducer array (408) includes at least one transducer element (412) having a first (604) and second (606) portions separated by an acoustical discontinuity (520). The first portion (604) has the desired length to form a half-wave k31 resonance, while the second portion (606) has a resonant length for an undesired very low frequency out-of-band k31 resonance. The thickness of the transducer element (412) is designed for k33 half-resonance. Given the design, the transducer element (412) can operate and provide for both forward-looking (514) and side looking (512) elevation apertures. A method is also disclosed for using the disclosed ultrasound transducer (412) in ultrasound imaging.
Abstract translation: 超声换能器阵列（408）包括至少一个换能器元件（412），该换能器元件具有由声学不连续性（520）隔开的第一（604）和第二（606）部分。 第一部分（604）具有期望的长度以形成半波k31谐振，而第二部分（606）具有用于不期望的非常低频带外k31谐振的谐振长度。 换能器元件（412）的厚度被设计用于k33半共振。 考虑到设计，换能器元件（412）可以操作并提供前视（514）和侧视（512）仰角孔。 还公开了在超声成像中使用所公开的超声换能器（412）的方法。
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公开(公告)号：US06457365B1
公开(公告)日：2002-10-01
申请号：US09501106
申请日：2000-02-09
Applicant: Douglas N. Stephens , Matthew O'Donnell
Inventor： Douglas N. Stephens , Matthew O'Donnell
IPC: G01N2924
CPC classification number: B06B1/0633 , A61B8/12 , A61B8/445 , A61B8/4488 , Y10T29/42
Abstract: An ultrasound transducer array (408) includes at least one transducer element (412) having a first (604) and second (606) portions separated by an acoustical discontinuity (520). The first portion (604) has the desired length to form a half-wave k31 resonance, while the second portion (606) has a resonant length for an undesired very low frequency out-of-band k31 resonance. The thickness of the transducer element (412) is designed for k33 half-resonance. Given the design, the transducer element (412) can operate and provide for both forward-looking (514) and side looking (512) elevation apertures. A method is also disclosed for using the disclosed ultrasound transducer (412) in ultrasound imaging.
Abstract translation: 超声换能器阵列（408）包括至少一个换能器元件（412），该换能器元件具有由声学不连续性（520）隔开的第一（604）和第二（606）部分。 第一部分（604）具有期望的长度以形成半波k31谐振，而第二部分（606）具有用于不期望的非常低频带外k31谐振的谐振长度。 换能器元件（412）的厚度被设计用于k33半共振。 考虑到设计，换能器元件（412）可以操作并提供前视（514）和侧视（512）仰角孔。 还公开了在超声成像中使用所公开的超声换能器（412）的方法。
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Patent Agency Ranking
公开(公告)号：US06224586B1
公开(公告)日：2001-05-01
申请号：US09391071
申请日：1999-09-04
Applicant: Douglas N. Stephens
Inventor： Douglas N. Stephens
IPC: A61M2500
CPC classification number: A61M25/0105
Abstract: A catheter position guide (100) includes a first open channel (104) along the length of the position guide (100) designed to receive a catheter (202). An optional second channel (112) substantially on the opposite side of the first channel (104) is designed to receive a guide wire (204). One or more hubs (106, 108) help retain the catheter position guide's proximal end (110) to a pullback device (310).
Abstract translation: 导管位置导向器（100）包括沿位置导向器（100）的长度设计成接收导管（202）的第一开放通道（104）。 基本上在第一通道（104）的相对侧上的可选的第二通道（112）设计成接收导丝（204）。 一个或多个轮毂（106,108）有助于将导管位置导向器的近端（110）保持到回拉装置（310）。
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7.发明申请Methods, Compositions and Device for Directed and Controlled Heating and Release of Agents 审中-公开用于定向和控制加热和释放试剂的方法，组合物和装置公开(公告)号：US20100068260A1
公开(公告)日：2010-03-18
申请号：US12508076
申请日：2009-07-23
Applicant: Dustin E. Kruse , Claude Meares , Katherine W. Ferrara , Eric Paoli , Douglas N. Stephens , Jeffrey Day
Inventor： Dustin E. Kruse , Claude Meares , Katherine W. Ferrara , Eric Paoli , Douglas N. Stephens , Jeffrey Day
CPC classification number: A61K38/55 , A61K9/1272 , A61K9/1277 , A61K9/5073 , A61K41/0028 , A61K45/06 , A61K47/6911 , A61K2300/00
Abstract: A composition coupled to an agent with a cleavable linker is provided. Specifically, the composition is used for releasing the agent through a temperature-sensitive mechanism at a targeted location in a subject with heat. It is advantageous to applications where there is a need to accurately deploy an agent in a targeted location to reduce adverse side effects or increase efficacy of the agent. A device and method for providing heat at the targeted location in the subject is also provided. The device and method allows release of the agents in a targeted manner and prevents overheating of the targeted location or the tissue surrounding the targeted location. It is advantageous to applications where there is a need to accurately control the temperature in a targeted location in a biological body, for instance, to deploy an agent in the targeted location.
Abstract translation: 提供了与具有可切割连接子的试剂偶联的组合物。 具体地说，该组合物用于通过热量在受试者的目标位置通过温度敏感性机构释放药剂。 需要在目标位置准确地部署试剂以减少不良副作用或增加试剂功效的应用是有利的。 还提供了一种用于在受试者的目标位置提供热量的装置和方法。 该装置和方法允许以有针对性的方式释放试剂，并防止目标位置或围绕目标位置的组织过热。 对于需要精确地控制生物体内的目标位置的温度的应用，例如在目标位置部署试剂是有利的。
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8.发明授权High resolution intravascular ultrasound transducer assembly having a flexible substrate 失效具有柔性基底的高分辨率血管内超声换能器组件公开(公告)号：US07226417B1
公开(公告)日：2007-06-05
申请号：US08712576
申请日：1996-09-13
Applicant: Michael J. Eberle , Douglas N. Stephens , Gary Rizzuti , Horst F. Kiepen , Andreas Hodjicostis
Inventor： Michael J. Eberle , Douglas N. Stephens , Gary Rizzuti , Horst F. Kiepen , Andreas Hodjicostis
CPC classification number: B06B1/0633 , G10K11/004 , Y10T29/42 , Y10T29/49005 , Y10T29/49124
Abstract: An ultrasound transducer assembly of the present invention includes a flexible circuit to which an ultrasound transducer array and integrated circuitry are attached during fabrication of the ultrasound transducer assembly. The flexible circuit comprises a flexible substrate to which the integrated circuitry and transducer elements are attached while the flexible substrate is in a substantially flat shape. The flexible circuit further comprises electrically conductive lines that are deposited upon the flexible substrate. The electrically conductive lines transport electrical signals between the integrated circuitry and the transducer elements. After assembly, the flexible circuit is re-shapable into a final form such as, for example, a substantially cylindrical shape.
Abstract translation: 本发明的超声换能器组件包括柔性电路，超声波换能器阵列和集成电路在制造超声换能器组件期间连接到该柔性电路。 柔性电路包括柔性基板，其中集成电路和换能器元件被附接到柔性基板，同时柔性基板处于基本平坦的形状。 柔性电路还包括沉积在柔性基板上的导电线。 导电线传输集成电路和换能器元件之间的电信号。 在组装之后，柔性电路可重新成型为最终形式，例如大致圆柱形的形状。
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9.发明申请High Resolution Intravascular Ultrasound Transducer Assembly Having A Flexible Substrate 审中-公开具有柔性基板的高分辨率血管内超声传感器组件公开(公告)号：US20110034809A1
公开(公告)日：2011-02-10
申请号：US12903545
申请日：2010-10-13
Applicant: Michael J. Eberle , Douglas N. Stephens , Gary Rizzuti , Horst F. Kiepen , Andreas Hodjicostis
Inventor： Michael J. Eberle , Douglas N. Stephens , Gary Rizzuti , Horst F. Kiepen , Andreas Hodjicostis
CPC classification number: B06B1/0633 , G10K11/004 , Y10T29/42 , Y10T29/49005 , Y10T29/49124
Abstract: An ultrasound transducer assembly of the present invention includes a flexible circuit to which an ultrasound transducer array and integrated circuitry are attached during fabrication of the ultrasound transducer assembly. The flexible circuit comprises a flexible substrate to which the integrated circuitry and transducer elements are attached while the flexible substrate is in a substantially flat shape. The flexible circuit further comprises electrically conductive lines that are deposited upon the flexible substrate. The electrically conductive lines transport electrical signals between the integrated circuitry and the transducer elements. After assembly, the flexible circuit is re-shapable into a final form such as, for example, a substantially cylindrical shape.
Abstract translation: 本发明的超声换能器组件包括柔性电路，超声波换能器阵列和集成电路在制造超声换能器组件期间连接到该柔性电路。 柔性电路包括柔性基板，其中集成电路和换能器元件被附接到柔性基板，同时柔性基板处于基本平坦的形状。 柔性电路还包括沉积在柔性基板上的导电线。 导电线传输集成电路和换能器元件之间的电信号。 在组装之后，柔性电路可重新成型为最终形式，例如大致圆柱形的形状。
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10.发明授权High resolution intravascular ultrasound transducer assembly having a flexible substrate 有权具有柔性基底的高分辨率血管内超声换能器组件公开(公告)号：US07846101B2
公开(公告)日：2010-12-07
申请号：US11757816
申请日：2007-06-04
Applicant: Michael J. Eberle , Douglas N. Stephens , Gary Rizzuti , Horst Kiepen , Andreas Hodjicostis
Inventor： Michael J. Eberle , Douglas N. Stephens , Gary Rizzuti , Horst Kiepen , Andreas Hodjicostis
CPC classification number: B06B1/0633 , G10K11/004 , Y10T29/42 , Y10T29/49005 , Y10T29/49124
Abstract: An ultrasound transducer assembly of the present invention includes a flexible circuit to which an ultrasound transducer array and integrated circuitry are attached during fabrication of the ultrasound transducer assembly. The flexible circuit comprises a flexible substrate to which the integrated circuitry and transducer elements are attached while the flexible substrate is in a substantially flat shape. The flexible circuit further comprises electrically conductive lines that are deposited upon the flexible substrate. The electrically conductive lines transport electrical signals between the integrated circuitry and the transducer elements. After assembly, the flexible circuit is re-shapable into a final form such as, for example, a substantially cylindrical shape.
Abstract translation: 本发明的超声换能器组件包括柔性电路，超声波换能器阵列和集成电路在制造超声换能器组件期间连接到该柔性电路。 柔性电路包括柔性基板，其中集成电路和换能器元件被附接到柔性基板，同时柔性基板处于基本平坦的形状。 柔性电路还包括沉积在柔性基板上的导电线。 导电线传输集成电路和换能器元件之间的电信号。 在组装之后，柔性电路可重新成型为最终形式，例如大致圆柱形的形状。
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