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1.发明申请Listeria-induced immunorecruitment and activation, and methods of use thereof 审中-公开李斯特菌引起的免疫反应和活化及其使用方法公开(公告)号：US20070190029A1
公开(公告)日：2007-08-16
申请号：US11507734
申请日：2006-08-21
申请人： Drew Pardoll , Richard Schulick , Keith Bahjat , Dirk Brockstedt , Thomas Dubensky , Martin Giedlin , Kiyoshi Yoshimura , Ajay Jain
发明人： Drew Pardoll , Richard Schulick , Keith Bahjat , Dirk Brockstedt , Thomas Dubensky , Martin Giedlin , Kiyoshi Yoshimura , Ajay Jain
CPC分类号： A61K39/0011 , A61K31/675 , A61K35/13 , A61K35/74 , A61K38/193 , A61K2039/505 , A61K2039/522 , A61K2039/55522 , A61K2039/55544 , C07K16/2812 , C07K16/2815 , C12N1/36 , Y02A50/41 , A61K2300/00 , A61K38/00
摘要： Provided are reagents and methods for administering an attenuated bacterium for use in treating a cancerous or infectious condition. Reagents and methods for administering an attenuated bacterium for use in inducing an immune response against a tumor, cancer cell, or infective agent are further provided. Also provided are methods of diagnosis and kits.
摘要翻译： 提供了用于施用用于治疗癌性或感染性病症的减毒细菌的试剂和方法。 还提供了用于施用用于诱导针对肿瘤，癌细胞或感染剂的免疫应答的减毒细菌的试剂和方法。 还提供诊断和试剂盒的方法。
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公开(公告)号：US20070190063A1
公开(公告)日：2007-08-16
申请号：US11507810
申请日：2006-08-21
申请人： Keith Bahjat , Dirk Brockstedt , William Greenman
发明人： Keith Bahjat , Dirk Brockstedt , William Greenman
IPC分类号： A61K39/42 , A61K39/395 , A61K39/02
CPC分类号： A61K39/39558 , A61K2039/505 , A61K2039/522 , Y02A50/41 , A61K2300/00
摘要： Provided are reagents and methods for administering an attenuated bacterium and a binding compound for treating a cancerous or infectious condition, where the binding compound comprises an antibody or an antigen binding site derived from an antibody.
摘要翻译： 提供了用于施用减毒细菌和用于治疗癌性或感染性病症的结合化合物的试剂和方法，其中结合化合物包含抗体或源自抗体的抗原结合位点。
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3.发明申请公开(公告)号：US20140037662A1
公开(公告)日：2014-02-06
申请号：US13988076
申请日：2011-11-17
申请人： Peter M. Lauer , Keith Bahjat
发明人： Peter M. Lauer , Keith Bahjat
IPC分类号： C07K14/71
CPC分类号： A61K39/0011 , A61K38/00 , A61K2039/522 , A61K2039/523 , C07K14/71
摘要： The present invention relates to methods of inducing a T-cell response against a EGFRvIII in a subject. These method comprise administering to a subject a composition which expresses at least one immunogenic polypeptide, the amino acid sequence of which comprise a plurality of EGFRvIII polypeptide sequences, the sequence of which each comprise EEKKGNYV (SEQ ID NO: 3), and/or administering the polypeptide itself.
摘要翻译： 本发明涉及在受试者中诱导针对EGFRvIII的T细胞应答的方法。 这些方法包括对受试者施用表达至少一种免疫原性多肽的组合物，所述组合物的氨基酸序列包含多个EGFRvIII多肽序列，其序列各自包含EEKKGNYV（SEQ ID NO：3）和/或施用 多肽本身。
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公开(公告)号：US20050013745A1
公开(公告)日：2005-01-20
申请号：US10497942
申请日：2002-12-09
申请人： Kristopher Buchanan , Nathan Fox , Keith Bahjat
发明人： Kristopher Buchanan , Nathan Fox , Keith Bahjat
CPC分类号： B01L3/50855 , B01L1/52 , B01L9/06 , B01L9/523 , B01L2200/022 , B01L2300/0829 , G01N35/026 , G01N2035/0427
摘要： A sample carrier system (1) with spatially adjustable configuration provides variable positioning as to the relative location of a plurality of sample containment elements (1). In a preferred embodiment, a slidably reconfigurable sampling system in which a matrix type, row-by-row arrangement of receptacles or sample retention elements (1) for specimen carriers such as cuvettes, test tubes and beakers, or the like (40), or for samples (41), may be reconfigured into a substantially linear arrangement of individual specimen carriers along with the entrained material contents, providing more accurate testing processes and more reliable test results.
摘要翻译： 具有空间可调配置的样品载体系统（1）提供关于多个样品容纳元件（1）的相对位置的可变定位。 在优选实施例中，可滑动地重新配置的采样系统，其中用于样本载体（如比色皿，试管和烧杯等）的容器或样品保留元件（1）的逐排排列， 或对于样品（41），可以重新配置成单个样品载体的基本线性布置以及夹带的材料含量，提供更准确的测试过程和更可靠的测试结果。
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5.发明授权公开(公告)号：US09200057B2
公开(公告)日：2015-12-01
申请号：US13988076
申请日：2011-11-17
申请人： Peter M. Lauer , Keith Bahjat
发明人： Peter M. Lauer , Keith Bahjat
CPC分类号： A61K39/0011 , A61K38/00 , A61K2039/522 , A61K2039/523 , C07K14/71
摘要： The present invention relates to methods of inducing a T-cell response against a EGFRvIII in a subject. These method comprise administering to a subject a composition which expresses at least one immunogenic polypeptide, the amino acid sequence of which comprise a plurality of EGFRvIII polypeptide sequences, the sequence of which each comprise EEKKGNYV (SEQ ID NO: 3), and/or administering the polypeptide itself.
摘要翻译： 本发明涉及在受试者中诱导针对EGFRvIII的T细胞应答的方法。 这些方法包括对受试者施用表达至少一种免疫原性多肽的组合物，所述组合物的氨基酸序列包含多个EGFRvIII多肽序列，其序列各自包含EEKKGNYV（SEQ ID NO：3）和/或施用 多肽本身。
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