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公开(公告)号：US09278138B2
公开(公告)日：2016-03-08
申请号：US14191871
申请日：2014-02-27
IPC分类号： C07K7/04 , C07K7/08 , A61K38/04 , A61K38/16 , A61Q5/00 , A61K47/48 , C07K14/00 , G01N33/68 , G06F19/16 , A61K8/64
CPC分类号： A61K47/48338 , A61K8/19 , A61K8/64 , A61K2800/94 , A61Q5/00 , A61Q5/065 , C07K14/001 , C07K2319/70 , G01N33/6803 , G06F19/16
摘要： Short single chain peptides having affinity for a target surface often lack the binding durability required for certain commercial applications. One way to improve durability is to promote multivalent binding by linking together binding sequences using peptide linkers. However, the resulting single chain binding peptides often suffer from linker entropy. It has been discovered that the use of rigid peptide linkers when linking together multiple binding sequences enhances the binding affinity of the resulting single chain peptide.
摘要翻译： 对目标表面具有亲和性的短单链肽通常缺乏某些商业应用所需的结合耐久性。 提高耐久性的一种方法是通过使用肽接头连接在一起的结合序列来促进多价结合。 然而，所得到的单链结合肽通常具有接头熵。 已经发现，当将多个结合序列连接在一起时，使用刚性肽接头增强所得单链肽的结合亲和力。
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公开(公告)号：US20140241999A1
公开(公告)日：2014-08-28
申请号：US14191871
申请日：2014-02-27
CPC分类号： A61K47/48338 , A61K8/19 , A61K8/64 , A61K2800/94 , A61Q5/00 , A61Q5/065 , C07K14/001 , C07K2319/70 , G01N33/6803 , G06F19/16
摘要： Short single chain peptides having affinity for a target surface often lack the binding durability required for certain commercial applications. One way to improve durability is to promote multivalent binding by linking together binding sequences using peptide linkers. However, the resulting single chain binding peptides often suffer from linker entropy. It has been discovered that the use of rigid peptide linkers when linking together multiple binding sequences enhances the binding affinity of the resulting single chain peptide.
摘要翻译： 对目标表面具有亲和性的短单链肽通常缺乏某些商业应用所需的结合耐久性。 提高耐久性的一种方法是通过使用肽接头连接在一起的结合序列来促进多价结合。 然而，所得到的单链结合肽通常具有接头熵。 已经发现，当将多个结合序列连接在一起时，使用刚性肽接头增强所得单链肽的结合亲和力。
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