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公开(公告)号：US20230235345A1
公开(公告)日：2023-07-27
申请号：US18056372
申请日：2022-11-17
发明人： ANDREW MARK CIGAN , SAVERIO CARL FALCO , HUIRONG GAO , ZHONGSEN LI , ZHAN-BIN LIU , L. ALEKSANDER LYZNIK , JINRUI SHI , SERGEI SVITASHEV , JOSHUA K. YOUNG
CPC分类号： C12N15/8216 , C12N15/63 , C12N15/00 , C12N15/8274 , C12N15/8213 , C12N15/8247 , A01H1/00
摘要： Compositions and methods are provided for genome modification of a target sequence in the genome of a plant or plant cell. The methods and compositions employ a guide RNA/Cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a plant, plant cell or seed. Also provided are compositions and methods employing a guide polynucleotide/Cas endonuclease system for genome modification of a nucleotide sequence in the genome of a cell or organism, for gene editing, and/or for inserting or deleting a polynucleotide of interest into or from the genome of a cell or organism. Once a genomic target site is identified, a variety of methods can be employed to further modify the target sites such that they contain a variety of polynucleotides of interest. Breeding methods and methods for selecting plants utilizing a two component RNA guide and Cas endonuclease system are also disclosed. Compositions and methods are also provided for editing a nucleotide sequence in the genome of a cell.
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公开(公告)号：US20230279413A1
公开(公告)日：2023-09-07
申请号：US18056002
申请日：2022-11-16
发明人： ANDREW MARK CIGAN , SAVERIO CARL FALCO , HUIRONG GAO , ZHONGSEN LI , ZHAN-BIN LIU , L. ALEKSANDER LYZNIK , JINRUI SHI , SERGEI SVITASHEV , JOSHUA K. YOUNG
CPC分类号： C12N15/8216 , C12N15/00 , C12N15/63 , C12N15/8213 , C12N15/8247 , C12N15/8274 , A01H1/00
摘要： Compositions and methods are provided for genome modification of a target sequence in the genome of a plant or plant cell. The methods and compositions employ a guide RNA/Cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a plant, plant cell or seed. Also provided are compositions and methods employing a guide polynucleotide/Cas endonuclease system for genome modification of a nucleotide sequence in the genome of a cell or organism, for gene editing, and/or for inserting or deleting a polynucleotide of interest into or from the genome of a cell or organism. Once a genomic target site is identified, a variety of methods can be employed to further modify the target sites such that they contain a variety of polynucleotides of interest. Breeding methods and methods for selecting plants utilizing a two component RNA guide and Cas endonuclease system are also disclosed. Compositions and methods are also provided for editing a nucleotide sequence in the genome of a cell.
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公开(公告)号：US20230323374A1
公开(公告)日：2023-10-12
申请号：US18055614
申请日：2022-11-15
发明人： ANDREW MARK CIGAN , SAVERIO CARL FALCO , HUIRONG GAO , ZHONGSEN LI , ZHAN-BIN LIU , L. ALEKSANDER LYZNIK , JINRUI SHI , SERGEI SVITASHEV , JOSHUA K. YOUNG
CPC分类号： C12N15/8216 , C12N15/00 , C12N15/63 , C12N15/8213 , C12N15/8247 , C12N15/8274 , A01H1/00
摘要： Compositions and methods are provided for genome modification of a target sequence in the genome of a plant or plant cell. The methods and compositions employ a guide RNA/Cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a plant, plant cell or seed. Also provided are compositions and methods employing a guide polynucleotide/Cas endonuclease system for genome modification of a nucleotide sequence in the genome of a cell or organism, for gene editing, and/or for inserting or deleting a polynucleotide of interest into or from the genome of a cell or organism. Once a genomic target site is identified, a variety of methods can be employed to further modify the target sites such that they contain a variety of polynucleotides of interest. Breeding methods and methods for selecting plants utilizing a two component RNA guide and Cas endonuclease system are also disclosed. Compositions and methods are also provided for editing a nucleotide sequence in the genome of a cell.
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公开(公告)号：US20200157554A1
公开(公告)日：2020-05-21
申请号：US16777401
申请日：2020-01-30
发明人： ANDREW MARK CIGAN , SAVERIO CARL FALCO , HUIRONG GAO , ZHONGSEN LI , ZHAN-BIN LIU , L. ALEKSANDER LYZNIK , JINRUI SHI , SERGEI SVITASHEV , JOSHUA K. YOUNG
IPC分类号： C12N15/82 , C12N15/113 , A01H5/00 , A01H1/00
摘要： Compositions and methods are provided for genome modification of a target sequence in the genome of a plant or plant cell. The methods and compositions employ a guide RNA/Cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a plant, plant cell or seed. Also provided are compositions and methods employing a guide polynucleotide/Cas endonuclease system for genome modification of a nucleotide sequence in the genome of a cell or organism, for gene editing, and/or for inserting or deleting a polynucleotide of interest into or from the genome of a cell or organism. Once a genomic target site is identified, a variety of methods can be employed to further modify the target sites such that they contain a variety of polynucleotides of interest. Breeding methods and methods for selecting plants utilizing a two component RNA guide and Cas endonuclease system are also disclosed. Compositions and methods are also provided for editing a nucleotide sequence in the genome of a cell.
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公开(公告)号：US20190040405A1
公开(公告)日：2019-02-07
申请号：US16130295
申请日：2018-09-13
发明人： ANDREW MARK CIGAN , SAVERIO CARL FALCO , HUIRONG GAO , ZHONGSEN LI , ZHAN-BIN LIU , LESZEK ALEKSANDER LYZNIK , JINRUI SHI , SERGEI SVITASHEV , JOSHUA K. YOUNG
IPC分类号： C12N15/82 , C12N15/113 , C12N15/81 , C12Q1/6895
摘要： Compositions and methods are provided for genome modification of a target sequence in the genome of a plant or plant cell. The methods and compositions employ a guide RNA/Cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a plant, plant cell or seed. Also provided are compositions and methods employing a guide polynucleotide/Cas endonuclease system for genome modification of a nucleotide sequence in the genome of a cell or organism, for gene editing, and/or for inserting or deleting a polynucleotide of interest into or from the genome of a cell or organism. Once a genomic target site is identified, a variety of methods can be employed to further modify the target sites such that they contain a variety of polynucleotides of interest. Breeding methods and methods for selecting plants utilizing a two component RNA guide and Cas endonuclease system are also disclosed. Compositions and methods are also provided for editing a nucleotide sequence in the genome of a cell.
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6.发明申请公开(公告)号：US20170183677A1
公开(公告)日：2017-06-29
申请号：US15323772
申请日：2015-07-13
发明人： HUIRONG GAO , XIAOMU NIU , JINRUI SHI
CPC分类号： C12N15/8249 , C12N9/88 , C12N15/8213 , C12N15/8261 , C12N15/8271 , C12N15/8273 , C12N15/8275 , C12Y301/03012 , C12Y404/01014
摘要： Compositions and methods are provided for agronomic trait modification of a target sequence in the genome of a plant or plant cell. The methods and compositions employ a guide RNA/Cas endonuclease system to provide an effective system for modifying or altering target sites within a genomic region of a plant, plant cell or seed to provide improvement in a desirable agronomic trait such as drought, yield, and stress tolerance. Breeding methods for selecting plants utilizing a two component RNA guide and Cas endonuclease system are also disclosed. Compositions and methods are also provided for editing a nucleotide sequence in the genome of a cell.
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公开(公告)号：US20170247716A1
公开(公告)日：2017-08-31
申请号：US15440753
申请日：2017-02-23
发明人： Rayeann Archibald , BRUCE DRUMMOND , JINRUI SHI , HONGYU WANG
CPC分类号： C12Q1/6895 , C12N15/8249 , C12N15/8273 , C12Q2600/13 , C12Q2600/156 , C12Q2600/172
摘要： Nucleotide sequences encoding RTL polypeptides are provided herein, along with plants and cells having increased levels of RTL gene expression, increased levels of RTL transcription factor activity, or both. Plants with increased levels of at least one RTL gene expression that exhibit reduced ethylene sensitivity, increased yield, increased abiotic stress tolerance, or any combination of these, are provided. Methods for increasing yield, and abiotic stress tolerance in plants, by modulating RTL gene expression or activity, are also provided.
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公开(公告)号：US20220364107A1
公开(公告)日：2022-11-17
申请号：US17656594
申请日：2022-03-25
发明人： HUIRONG GAO , XIAOMU NIU , JINRUI SHI
摘要： Compositions and methods are provided for agronomic trait modification of a target sequence in the genome of a plant or plant cell. The methods and compositions employ a guide RNA/Cas endonuclease system to provide an effective system for modifying or altering target sites within a genomic region of a plant, plant cell or seed to provide improvement in a desirable agronomic trait such as drought, yield, and stress tolerance. Breeding methods for selecting plants utilizing a two component RNA guide and Cas endonuclease system are also disclosed. Compositions and methods are also provided for editing a nucleotide sequence in the genome of a cell.
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9.发明申请公开(公告)号：US20210222183A1
公开(公告)日：2021-07-22
申请号：US17151856
申请日：2021-01-19
发明人： HUIRONG GAO , JEFFREY HABBEN , SABRINA HUMBERT , JINRUI SHI
IPC分类号： C12N15/82
摘要： The disclosure provides plant, plant parts, plant cells, seed and grain containing a targeted genetic modification that inserts an inverted repeat sequence into a gene. The disclosure further provides hybrid plants that contain the inverted repeat sequence in a single allele of the gene. Further provided are methods for decreasing expression of a gene encoding a polypeptide of interest in a hybrid plant by crossing a plant comprising the targeted genetic modification with a plant not comprising the genetic modification to produce a hybrid plant that contains the inverted repeat sequence in a single allele of the gene.
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