公开(公告)号：US09482619B2

公开(公告)日：2016-11-01

申请号：US14152320

申请日：2014-01-10

Applicant: East China University of Science and Technology

Inventor： Yitao Long ,  Dawei Li ,  Lulu Qu ,  Wenlei Zhai ,  Jinqun Xue ,  Wei Song

IPC: G01J3/44 ,  G01N21/65 ,  G01N21/552 ,  G01N33/18 ,  B22F1/02 ,  B22F1/00

CPC classification number: G01N21/658 ,  B22F1/0018 ,  B22F1/0051 ,  B22F1/02 ,  B22F2999/00 ,  G01N21/554 ,  G01N33/18 ,  B22F2303/01 ,  B22F2301/255 ,  B22F2303/30 ,  B22F2302/256

Abstract: Provided herein are Raman active particles and methods for their preparation and use. The particles can include a SERS-active material that is at least partially encased within a spherical porous hollow casing. In some embodiments, this can be especially advantageous when employed for water analysis and/or being employed in combination with silica particles.

Abstract translation: 本文提供的是拉曼活性颗粒及其制备和使用的方法。 颗粒可以包括至少部分地包裹在球形多孔中空壳体内的SERS-活性材料。 在一些实施方案中，当用于水分析和/或与二氧化硅颗粒组合使用时，这可能是特别有利的。

公开(公告)号：US10788450B2

公开(公告)日：2020-09-29

申请号：US15546671

申请日：2016-01-08

Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Yitao Long ,  Chan Cao ,  Yongxu Hu

IPC: C12Q1/6869 ,  G01N33/487 ,  G01N27/447

Abstract: A preparation method for an aerolysin nanopore in this disclosure comprises the following steps: (1) pretreatment of an aerolysin; (2) preparation of a lipid bilayer membrane by pulling process; (3) forming of the aerolysin nanopore: the aerolysin nanopore is obtained at a current of 50±5 pA. The aerolysin nanopore prepared in the invention is structurally stable and has a high resolution with the whole internal cavity carried with a positive charge, can be used for detection without modification and is easily operated. Further, the aerolysin nanopore can be applied in DNA sequencing, DNA damage and Micro-RNA detection.

公开(公告)号：US20140127402A1

公开(公告)日：2014-05-08

申请号：US14152320

申请日：2014-01-10

Applicant: East China University of Science and Technology

Inventor： Yitao Long ,  Dawei Li ,  Lulu Qu ,  Wenlei Zhai ,  Jinqun Xue ,  Wei Song

IPC: G01N21/65

CPC classification number: G01N21/658 ,  B22F1/0018 ,  B22F1/0051 ,  B22F1/02 ,  B22F2999/00 ,  G01N21/554 ,  G01N33/18 ,  B22F2303/01 ,  B22F2301/255 ,  B22F2303/30 ,  B22F2302/256

Abstract: Provided herein are Raman active particles and methods for their preparation and use. The particles can include a SERS-active material that is at least partially encased within a spherical porous hollow casing. In some embodiments, this can be especially advantageous when employed for water analysis and/or being employed in combination with silica particles

Abstract translation: 本文提供的是拉曼活性颗粒及其制备和使用的方法。 颗粒可以包括至少部分地包裹在球形多孔中空壳体内的SERS-活性材料。 在一些实施方案中，当用于水分析和/或与二氧化硅颗粒组合使用时，这可能是特别有利的