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公开(公告)号：US20230181316A1
公开(公告)日：2023-06-15
申请号：US18164421
申请日：2023-02-03
发明人： Hengchu Cao , Brian S. Conklin , Paul A. Schmidt , Grace Myong Kim , James A. Davidson , Hoa Trinh Tran , Kristy Luong Tam
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/2412 , A61F2/2415 , A61F2/2409
摘要： Disclosed prosthetic valves can comprise a sewing ring configured to secure the valve to an implantation site. Some disclosed valves comprise a resiliently collapsible frame having a neutral configuration and a collapsed deployment configuration. Some disclosed frames can self-expand to the neutral configuration when released from the collapsed deployment configuration. Collapsing a disclosed valve can provide convenient access to the sewing ring, such as for securing the valve to the implantation site, as well as for the insertion of the valve through relatively small surgical incisions.
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公开(公告)号：US20220241462A1
公开(公告)日：2022-08-04
申请号：US17659589
申请日：2022-04-18
摘要： A bioprosthetic tissue having a reduced propensity to calcify in vivo, the bioprosthetic tissue. The bioprosthetic tissue comprises an aldehyde cross-linked and stressed bioprosthetic tissue comprising exposed calcium, phosphate or immunogenic binding sites that have been reacted with a calcification mitigant. The bioprosthetic tissue has a reduced propensity to calcify in vivo as compared to aldehyde cross-linked bioprosthetic tissue that has not been stressed and reacted with the calcification mitigant.
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公开(公告)号：US11305036B2
公开(公告)日：2022-04-19
申请号：US16595089
申请日：2019-10-07
摘要： A bioprosthetic tissue having a reduced propensity to calcify in vivo, the bioprosthetic tissue. The bioprosthetic tissue comprises an aldehyde cross-linked and stressed bioprosthetic tissue comprising exposed calcium, phosphate or immunogenic binding sites that have been reacted with a calcification mitigant. The bioprosthetic tissue has a reduced propensity to calcify in vivo as compared to aldehyde cross-linked bioprosthetic tissue that has not been stressed and reacted with the calcification mitigant.
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公开(公告)号：US10966822B2
公开(公告)日：2021-04-06
申请号：US16253051
申请日：2019-01-21
摘要： A method for manufacturing a heart valve using bioprosthetic tissue that exhibits reduced in vivo calcification. The method includes applying a calcification mitigant such as a capping agent or an antioxidant to the tissue to specifically inhibit oxidation in tissue. Also, the method can be used to inhibit oxidation in dehydrated tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the oxidation and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. In one method, tissue leaflets in assembled bioprosthetic heart valves are pretreated with an aldehyde capping agent prior to dehydration and sterilization.
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公开(公告)号：US20200330226A1
公开(公告)日：2020-10-22
申请号：US16921901
申请日：2020-07-06
发明人： Hengchu Cao , Brian S. Conklin , Paul A. Schmidt , Grace Myong Kim , James A. Davidson , Hoa Trinh Tran , Kristy Luong Tam
IPC分类号： A61F2/24
摘要： Disclosed prosthetic valves can comprise a sewing ring configured to secure the valve to an implantation site. Some disclosed valves comprise a resiliently collapsible frame having a neutral configuration and a collapsed deployment configuration. Some disclosed frames can self-expand to the neutral configuration when released from the collapsed deployment configuration. Collapsing a disclosed valve can provide convenient access to the sewing ring, such as for securing the valve to the implantation site, as well as for the insertion of the valve through relatively small surgical incisions.
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公开(公告)号：US10434218B2
公开(公告)日：2019-10-08
申请号：US15879339
申请日：2018-01-24
摘要： A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification is disclosed. The method includes preconditioning, pre-stressing, or pre-damaging fixed bioprosthetic tissue in a manner that mimics the damage associated with post-implant use, while, and/or subsequently applying a calcification mitigant such as a capping agent or a linking agent to the damaged tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the damage process (service stress) and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. The linking agent will act as an elastic reinforcement or shock-absorbing spring element in the tissue structure at the site of damage from the pre-stressing. In one method, tissue leaflets in assembled bioprosthetic heart valves are preconditioned by simulating actual flow conditions for a predetermined number of cycles, during or after which the valve is exposed to the capping agent.
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公开(公告)号：US20130289695A1
公开(公告)日：2013-10-31
申请号：US13929606
申请日：2013-06-27
发明人： Bin Tian , James A. Davidson
IPC分类号： A61F2/24
CPC分类号： A61F2/2415 , A01N1/0215 , A61L27/3604 , A61L27/3687 , A61L27/507 , A61L2430/40
摘要： A method of treating a biological tissue that enables dry storage of said tissue is disclosed. In one embodiment, the method comprises contacting the biological tissue with a non-aqueous treatment solution comprising a polyhydric alcohol and a C1-C3 alcohol and removing a portion of the treatment solution from the solution-treated biological tissue. Also disclosed is biological tissue prepared using the above process and prosthetic devices made with such tissue.
摘要翻译： 公开了一种处理能够干燥储存所述组织的生物组织的方法。 在一个实施方案中，该方法包括使生物组织与包含多元醇和C 1 -C 3醇的非水性处理溶液接触，并从溶液处理的生物组织中除去一部分处理溶液。 还公开了使用上述方法制备的生物组织和由这种组织制成的假体装置。
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公开(公告)号：US11622861B2
公开(公告)日：2023-04-11
申请号：US17645940
申请日：2021-12-23
IPC分类号： A61F2/24
摘要： Compressible heart valve annulus sizing templates suitable for minimally-invasive or otherwise reduced accessibility surgeries. The sizing templates may be folded, rolled, or otherwise compressed into a reduced configuration for passage through an access tube or other such access channel. Once expelled from the access tube the sizing templates expand to their original shape for use in sizing the annulus. The templates may be formed of an elastomeric polymer material such as silicone, a highly elastic metal such as NITINOL, or both. Grasping tabs or connectors for handles permit manipulation from outside the body. A NITINOL wireform may be compressed for passage through an access tube and expelled from the distal end thereof into a cloth cover to assume a sizer shape.
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公开(公告)号：US20180318075A1
公开(公告)日：2018-11-08
申请号：US15990332
申请日：2018-05-25
发明人： Hengchu Cao , Brian S. Conklin , Paul A. Schmidt , Grace M. Kim , James A. Davidson , Hoa T. Tran , Kristy L. Tam
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/2409 , A61F2/2412 , A61F2/2415
摘要： Disclosed prosthetic valves can comprise a sewing ring configured to secure the valve to an implantation site. Some disclosed valves comprise a resiliently collapsible frame having a neutral configuration and a collapsed deployment configuration. Some disclosed frames can self-expand to the neutral configuration when released from the collapsed deployment configuration. Collapsing a disclosed valve can provide convenient access to the sewing ring, such as for securing the valve to the implantation site, as well as for the insertion of the valve through relatively small surgical incisions.
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公开(公告)号：US20160235528A1
公开(公告)日：2016-08-18
申请号：US15138123
申请日：2016-04-25
CPC分类号： A61F2/2415 , A61F2/0095 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61L27/3604 , A61L27/3625 , A61L27/3629 , A61L27/3687 , A61L27/3691 , A61L27/507 , A61L2400/02 , A61L2430/20
摘要： A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification. The method includes applying a calcification mitigant such as a capping agent or an antioxidant to the tissue to specifically inhibit oxidation in tissue. Also, the method can be used to inhibit oxidation in dehydrated tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the oxidation and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. In one method, tissue leaflets in assembled bioprosthetic heart valves are pretreated with an aldehyde capping agent prior to dehydration and sterilization.
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