公开(公告)号：US12186184B2

公开(公告)日：2025-01-07

申请号：US17657732

申请日：2022-04-01

Applicant: Edwards Lifesciences Corporation

Inventor： Liron Tayeb ,  Eran Goldberg ,  David Maimon ,  Adi Carmi ,  Arie Tylis ,  Ralph Schneider ,  Mohammad Jafari ,  Hengchu Cao ,  Eitan Atias

IPC: A61F2/24 ,  A61F2/88 ,  A61F2/90

Abstract: An expandable docking station includes an annular valve seat having an end, an annular outer wall comprising struts disposed around the valve seat, and links that connect the end of the annular valve seat to the annular outer wall. Each of the links extends from the struts of the annular outer wall directly toward a longitudinal axis that runs longitudinally through a center of the docking station, and to a corresponding one of a plurality of circumferentially spaced axially extending legs at least partially defining the annular valve seat. The outer wall is configured to conform to an interior shape of a blood vessel, when expanded inside the blood vessel, such that the outer wall can expand in multiple locations to conform to multiple bulges of the blood vessel and can contract in multiple locations to conform to multiple narrowed regions of the blood vessel.

公开(公告)号：US20230405279A1

公开(公告)日：2023-12-21

申请号：US18239696

申请日：2023-08-29

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Bingquan Su ,  Nima V. Nia ,  Douglas Thomas Dominick ,  Sakyasingh Tripathy ,  Hengchu Cao ,  Rene Santana

IPC: A61M25/04

CPC classification number: A61M25/04 ,  A61M2210/125

Abstract: A system for delivering a guidewire through a heart valve comprises a delivery catheter configured to pass through a blood flow pathway of a heart, an inner catheter having an inner lumen, a guidewire configured to pass through the inner lumen of the inner catheter, and a positioning device crimped onto an outer surface of the inner catheter. wherein. The delivery catheter is configured to receive the inner catheter, guidewire, and positioning device and is configured to prevent expansion of the positioning device. The positioning device is configured to expand upon removal from the delivery catheter.

公开(公告)号：US11806001B2

公开(公告)日：2023-11-07

申请号：US16850950

申请日：2020-04-16

Applicant: Edwards Lifesciences Corporation

Inventor： Hengchu Cao ,  Shih-Hwa Shen ,  Holly Kung Jung Hsu ,  Krystal Ya-Fong Lai

IPC: A61B17/00 ,  A61F2/24 ,  A61F2/90

CPC classification number: A61B17/00491 ,  A61F2/246 ,  A61F2/90 ,  A61B2017/005 ,  A61B2017/00243 ,  A61B2017/00495 ,  A61B2017/00522 ,  A61B2017/00557 ,  A61F2/2442 ,  A61F2/2445 ,  A61F2/2466 ,  A61F2250/0059

Abstract: Disclosed is a delivery device, kit, system, method, etc. for localized fusion of leaflets of a tissue valve, for example, a native heart valve, using an adhesive. The delivery device can have one or more capture features for capturing separate leaflets, for example, the anterior and posterior mitral leaflets. An applicator can be configured to apply a biocompatible adhesive between the captured leaflets, and one or more curing elements can be configured to cure the applied biocompatible adhesive. The kit can have the aforementioned delivery device, and the biocompatible adhesive used therewith. The method can include positioning the aforementioned delivery device adjacent the anterior and posterior mitral leaflets, capturing the mitral leaflets between the paddles of the delivery device, applying a biocompatible adhesive between the captured mitral leaflets via the applicator, and curing the applied biocompatible adhesive via the energy elements to locally fuse the mitral leaflets.

公开(公告)号：US11291540B2

公开(公告)日：2022-04-05

申请号：US16034794

申请日：2018-07-13

Applicant: Edwards Lifesciences Corporation

Inventor： Liron Tayeb ,  Eran Goldberg ,  David Maimon ,  Adi Carmi ,  Arie Tylis ,  Ofir Witzman ,  Ralph Schneider ,  Mohammad Jafari ,  Hengchu Cao ,  Eason Michael Abbott ,  Dustin P. Armer ,  Michael D. Franklin ,  Tomer Saar ,  Anatoly Dvorsky ,  John J. Desrosiers ,  Daniel James Murray ,  Michael G. Valdez ,  Assaf Bash ,  Amir Blumenfeld ,  Noa Axelrod ,  Eitan Atias

IPC: A61F2/24 ,  A61F2/90 ,  A61F2/88

Abstract: Docking stations for transcatheter valves are described. The docking stations can include an expandable frame, at least one sealing portion, and a valve seat. The expandable frame can be configured to conform to an interior shape of a portion of the circulatory system when expanded inside the circulatory system. The sealing portion can be configured to contact an interior surface of the circulatory system to create a seal. The valve seat can be connected to the expandable frame and can be configured to support an expandable transcatheter valve. The docking stations are adaptable to different anatomies/locations to allow implantation of a transcatheter valve in a variety of anatomies/locations.

公开(公告)号：US20200237357A1

公开(公告)日：2020-07-30

申请号：US16850950

申请日：2020-04-16

Applicant: Edwards Lifesciences Corporation

Inventor： Hengchu Cao ,  Shih-Hwa Shen ,  Holly Kung Jung Hsu ,  Krystal Ya-Fong Lai

IPC: A61B17/00 ,  A61F2/24 ,  A61F2/90

Abstract: Disclosed is a delivery device, kit, system, method, etc. for localized fusion of leaflets of a tissue valve, for example, a native heart valve, using an adhesive. The delivery device can have one or more capture features for capturing separate leaflets, for example, the anterior and posterior mitral leaflets. An applicator can be configured to apply a biocompatible adhesive between the captured leaflets, and one or more curing elements can be configured to cure the applied biocompatible adhesive. The kit can have the aforementioned delivery device, and the biocompatible adhesive used therewith. The method can include positioning the aforementioned delivery device adjacent the anterior and posterior mitral leaflets, capturing the mitral leaflets between the paddles of the delivery device, applying a biocompatible adhesive between the captured mitral leaflets via the applicator, and curing the applied biocompatible adhesive via the energy elements to locally fuse the mitral leaflets.

公开(公告)号：US20180296332A1

公开(公告)日：2018-10-18

申请号：US15953220

申请日：2018-04-13

Applicant: Edwards Lifesciences Corporation

Inventor： Eric Robert Dixon ,  Jensen Chen ,  Guillermo W. Moratorio ,  Hengchu Cao ,  Douglas Thomas Dominick ,  Sergio Delgado ,  Lauren R. Freschauf

IPC: A61F2/24

Abstract: An implantable prosthetic device includes a coaption portion, paddles, and clasps. The paddles are extendable from a folded closed position to an open position. A clasp is attached to each of the paddles. Each clasp has a fixed arm attached to the inner portion of the paddle and a moveable arm having a barbed portion. A hinge portion connects the fixed arm to the moveable arm. A cover wraps around at least a portion of the moveable arm of the clasp. At least one actuation suture is attached to the cover.

公开(公告)号：US20180296330A1

公开(公告)日：2018-10-18

申请号：US15927814

申请日：2018-03-21

Applicant: Edwards Lifesciences Corporation

Inventor： Eric Robert Dixon ,  Jensen Chen ,  Guillermo W. Moratorio ,  Hengchu Cao ,  Douglas Thomas Dominick ,  Sergio Delgado ,  Lauren R. Freschauf

IPC: A61F2/24

Abstract: An implantable prosthetic device includes a coaption portion, paddles, and clasps. The paddles having an outer portion and inner portion. The paddles are extendable from a folded closed position to an open position. A clasp is attached to each of the paddles. The clasps have a fixed arm attached to the inner portion of the paddle and a hoop-shaped moveable arm having a barbed portion. A hinge portion connects the fixed arm to the moveable arm.

公开(公告)号：US20180296328A1

公开(公告)日：2018-10-18

申请号：US15910951

申请日：2018-03-02

Applicant: Edwards Lifesciences Corporation

Inventor： Eric Robert Dixon ,  Jensen Chen ,  Guillermo W. Moratorio ,  Hengchu Cao ,  Douglas Thomas Dominick ,  Sergio Delgado ,  Lauren R. Freschauf

IPC: A61F2/24

Abstract: An implantable prosthetic device includes a coaption portion, paddles, and clasps. The paddles are extendable from a folded closed position to an open position. A clasp is attached to each of the paddles. The clasps have a fixed arm attached to the paddle and a moveable arm. The moveable arm has a barbed portion, a first eyelet, and a second eyelet. The hinge portion connects the fixed arm to the moveable arm. A first intermediate suture loop is attached to the first eyelet and a second intermediate suture loop is attached to the second eyelet. At least one actuation suture is attached to the first and second intermediate suture loops.

公开(公告)号：US20250099090A1

公开(公告)日：2025-03-27

申请号：US18476253

申请日：2023-09-27

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Hengchu Cao ,  Shih-Hwa Shen ,  Holly Kung Jung Hsu ,  Krystal Ya-Fong Lai

IPC: A61B17/00 ,  A61B17/08

Abstract: Disclosed is a delivery device, kit, system, method, etc. for localized fusion of leaflets of a tissue valve, for example, a native heart valve, using an adhesive. The delivery device can have one or more capture features for capturing separate leaflets, for example, the anterior and posterior mitral leaflets. An applicator can be configured to apply a biocompatible adhesive between the captured leaflets, and one or more curing elements can be configured to cure the applied biocompatible adhesive. The kit can have the aforementioned delivery device, and the biocompatible adhesive used therewith. The method can include positioning the aforementioned delivery device adjacent the anterior and posterior mitral leaflets, capturing the mitral leaflets between the paddles of the delivery device, applying a biocompatible adhesive between the captured mitral leaflets via the applicator, and curing the applied biocompatible adhesive via the energy elements to locally fuse the mitral leaflets.

公开(公告)号：US11969346B2

公开(公告)日：2024-04-30

申请号：US17163215

申请日：2021-01-29

Applicant: Edwards Lifesciences Corporation

Inventor： Hengchu Cao

IPC: A61F2/24 ,  A61B17/122 ,  A61B17/00 ,  A61B17/04 ,  A61B17/128 ,  A61F2/00

CPC classification number: A61F2/2463 ,  A61B17/1227 ,  A61B2017/00243 ,  A61B17/0487 ,  A61B2017/0496 ,  A61B17/1285 ,  A61F2/0077 ,  A61F2/2466 ,  A61F2210/0014 ,  A61F2220/0016 ,  A61F2220/0025 ,  A61F2220/0058

Abstract: In one embodiment, a leaflet capture device for improving the coaptation of heart valve leaflets is provided. The leaflet capture device can include a clip having a coupling member and a leaflet engagement portion. The coupling member has a lumen extending therethrough. The leaflet engagement portion is moveable toward and away from the coupling member. The leaflet capture device can be delivered by a support catheter, an inner shaft, and an actuating connector. Extending an end of the inner shaft away from the coupling member of the clip pulls the actuating connector to move the leaflet engagement portion away from the coupling member.