公开(公告)号：US20180354939A1

公开(公告)日：2018-12-13

申请号：US16108964

申请日：2018-08-22

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： J. Eric Carlson ,  Hans Hansen ,  Lynn Hawkins ,  Sally Ishizaka ,  Matthew Mackey ,  Shawn Schiller ,  Chikako Ogawa ,  Heather Davis ,  Atsushi Endo

IPC: C07D417/14 ,  C07D403/14 ,  C07D413/04 ,  C07D401/10 ,  C07D401/14 ,  C07D471/10 ,  C07D487/10 ,  C07D471/04 ,  C07D215/48 ,  C12Q1/6897 ,  G01N33/50 ,  C07D451/04 ,  C07D487/04 ,  C07D493/10 ,  C07D413/14

CPC classification number: C07D417/14 ,  C07B2200/07 ,  C07D215/48 ,  C07D401/10 ,  C07D401/14 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14 ,  C07D451/04 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C07D493/10 ,  C12Q1/6897 ,  G01N33/5023 ,  G01N33/5047

Abstract: Embodiments of the disclosure relate to selectively substituted quinolone compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

公开(公告)号：USRE47193E1

公开(公告)日：2019-01-08

申请号：US15668887

申请日：2017-08-04

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： J. Eric Carlson ,  Hans Hansen ,  Lynn Hawkins ,  Sally Ishizaka ,  Matthew Mackey ,  Shawn Schiller ,  Chikako Ogawa ,  Heather Davis ,  Atsushi Endo

IPC: C07D413/04 ,  C07D401/14 ,  C07D403/14 ,  C07D401/10 ,  C07D413/14 ,  C07D417/14 ,  C07D215/48 ,  C07D471/04 ,  C07D471/10 ,  C07D487/10 ,  C12Q1/6897 ,  C07D493/10 ,  C07D487/04 ,  G01N33/50 ,  C07D451/04

Abstract: Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

公开(公告)号：US10087174B2

公开(公告)日：2018-10-02

申请号：US15670904

申请日：2017-08-07

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： J. Eric Carlson ,  Lynn Hawkins ,  Sally Ishizaka ,  Shawn Schiller ,  Chikako Ogawa ,  Atsushi Endo

IPC: C07D413/14 ,  C07D417/14 ,  C07D413/04 ,  C07D215/48 ,  C07D471/04 ,  C07D487/10 ,  C07D471/10 ,  C07D401/14 ,  C07D401/10 ,  C07D403/14 ,  C07D451/04 ,  C07D487/04 ,  C07D493/10 ,  C12Q1/6897 ,  G01N33/50

Abstract: Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.