公开(公告)号：US20220090007A1

公开(公告)日：2022-03-24

申请号：US17424304

申请日：2020-01-21

申请人： ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM

发明人： Miao-Ping CHIEN

IPC分类号： C12N5/00 ,  G01N33/50 ,  C12M1/00 ,  C09B11/24 ,  G01N15/14 ,  G01N21/64 ,  G02B21/00

摘要： According to one method, a sample with cells contains a phototagging agent. The sample is imaged to identify at least one target cell to be isolated. The identified target cell in the sample is selectively irradiated with photo-activating light for selectively activating the phototagging agent in the target cell to change its fluorescence response. The irradiated target cell is isolated from other cells in the sample based on a difference in its fluorescence response compared to non-activated phototagging agent in the other cells. Further aspects are directed to a corresponding microscope system and chemical compound for use as the phototagging agent.