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公开(公告)号：US20240276959A1
公开(公告)日：2024-08-22
申请号：US18540440
申请日：2023-12-14
发明人： Roger Kingdon Craig , Franklin Gerardus Grosveld , Richard Wilhelm Janssens , Marinus Johannes Van Haperen
IPC分类号： A01K67/0278 , A01K67/0276 , C12N15/85 , C12P21/00
CPC分类号： A01K67/0278 , A01K67/0276 , C12P21/005 , A01K2207/15 , A01K2217/072 , A01K2217/15 , A01K2217/206 , A01K2227/105 , A01K2267/01 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C12N15/8509
摘要： A transgenic non-human mammal containing a heterologous lambda light chain gene locus, and/or a heterologous kappa light chain gene locus, and/or a heterologous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge.
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公开(公告)号：US12066441B2
公开(公告)日：2024-08-20
申请号：US17195416
申请日：2021-03-08
发明人： Jacobus Johannes Maria van Dongen , José Alberto Orfao de Matos Correia e Vale , Juan Alejandro Flores-Montero , Julia Maria Almeida Parra , Vincent Henricus Johannes van der Velden , Sebastian Böttcher , Andrew Craig Rawstron , Ruth Mary de Tute , Ludovic Bernard Simon Lhermitte , Vahid Asnafi , Ester Mejstríková , Tomasz Szczepanski , Paulo Jorge Monteiro Da Silva Lucio , Marta Martin Ayuso , Carlos Eduardo Pedreira
IPC分类号： G01N33/533 , G01N15/14 , G01N33/49 , G01N33/50 , G01N33/532 , G01N33/569 , G01N15/1404
CPC分类号： G01N33/56972 , G01N15/14 , G01N33/4915 , G01N33/5005 , G01N33/5091 , G01N33/5094 , G01N33/532 , G01N33/533 , G01N2015/1402 , G01N2015/1413
摘要： The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least there identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.
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公开(公告)号：US20240065551A1
公开(公告)日：2024-02-29
申请号：US18489637
申请日：2023-10-18
CPC分类号： A61B5/0035 , A61B5/0044 , A61B5/0086 , A61B5/0095 , A61B5/02007 , A61B5/4869 , A61B5/6852 , A61B8/0891 , A61B8/12 , A61B8/4416 , A61B8/4477 , A61B8/4483 , B06B1/0688 , G01S15/8956
摘要： A catheter-based imaging apparatus comprises a catheter having a proximal end and a distal end. An optical emitter is configured to emit optical excitation signals from a distal portion of the catheter. One or more ultrasound transducers are configured for: (a) transmission of acoustic excitation signals from the distal portion of the catheter; and (b) detection of ultrasound response signals from an object of interest at or near to the distal portion of the catheter at frequencies which include a lower receive frequency at least as low as 10 MHz and a higher receive frequency at least as high as 35 MHz. The one or more ultrasound transducers are thereby configured to detect response signals comprising photoacoustic response signals from the object of interest at the lower receive frequency and high resolution imaging signals from the object of interest at the higher receive frequency.
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4.发明授权公开(公告)号：US11802315B2
公开(公告)日：2023-10-31
申请号：US16633389
申请日：2018-08-09
发明人： Robby Ruijtenbeek , Dirgje Maria Adriana Van Den Heuvel , Richard De Wijn , Joan Gertrudis Jacobus Victor Aerts , Adrianus Henricus Josephus Mathijssen
IPC分类号： C12Q1/6886 , C12Q1/48
CPC分类号： C12Q1/6886 , C12Q1/485 , G01N2440/14 , G01N2800/52 , G01N2800/7028
摘要： The present invention relates to a method for determining or predicting the response of a patient diagnosed with non-small-cell lung carcinoma to targeted pharmacotherapy. The present invention also aims to provide methods and devices for predicting the response of patients diagnosed with non-small-cell lung carcinoma to specific medicaments. More specifically, the present invention provides methods which measure kinase-activity by studying phosphorylation levels and profiles and inhibitions thereof by drugs in blood samples of said patients.
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公开(公告)号：US20230211023A1
公开(公告)日：2023-07-06
申请号：US17907171
申请日：2021-03-25
发明人： Laura MEZZANOTTE
CPC分类号： A61K51/088 , C12N15/86 , C12Q1/66
摘要： The present invention provides a reporter system comprising (i) a gene expression construct for expression in a cell of a reporter gene, said reporter gene encoding a fusion protein comprising a transmembrane domain fused in-frame to a reporter domain, wherein said transmembrane domain upon insertion of the fusion protein into the cell membrane anchors the fusion protein in the cell membrane while expressing the reporter domain at the cell surface, and (ii) a reporter peptide labeled with a radiolabel, wherein said reporter domain comprises the large polypeptide subunit of a split luciferase, and wherein said reporter peptide comprises the small peptide subunit of said split luciferase, wherein both subunits associate by complementation to assemble into a luciferase complex.
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公开(公告)号：US11576574B2
公开(公告)日：2023-02-14
申请号：US16301366
申请日：2017-05-11
摘要： Method and contact lens (3) for measuring a subject's three dimensional eye movement including torsional movement. A video camera (1) is provided for recording an image of the subject's eye (2). The contact lens (3) is provided for placement over the subject's eye (2). The contact lens (3) comprises one or more markers (3a,3b) that are detectable by the video camera (1) and are positioned at a lateral offset (D) with respect to a central part (3p) of the contact lens (3). The one or more markers (3a,3b) are configured for detecting torsional rotation (R) of the subject's eye (2) around a line of sight axis (C) of the subject's eye (2) by using the video camera (1) to track a position of the one or more markers (3a,3b).
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公开(公告)号：US20220380730A1
公开(公告)日：2022-12-01
申请号：US17833506
申请日：2022-06-06
摘要： The invention is in the field of cell culturing. More specifically, it is in the field of generating and expanding myogenic cells from induced pluripotent stem (iPS) cells. The invention relates inter alia to cells generated and expanded via such a method, a growth medium specifically suited for the purpose of expanding isolated myogenic cells, and methods for screening compounds on cell structures such as myotubes and myofibers.
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公开(公告)号：US20220090007A1
公开(公告)日：2022-03-24
申请号：US17424304
申请日：2020-01-21
发明人： Miao-Ping CHIEN
摘要： According to one method, a sample with cells contains a phototagging agent. The sample is imaged to identify at least one target cell to be isolated. The identified target cell in the sample is selectively irradiated with photo-activating light for selectively activating the phototagging agent in the target cell to change its fluorescence response. The irradiated target cell is isolated from other cells in the sample based on a difference in its fluorescence response compared to non-activated phototagging agent in the other cells. Further aspects are directed to a corresponding microscope system and chemical compound for use as the phototagging agent.
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公开(公告)号：US20220087858A1
公开(公告)日：2022-03-24
申请号：US17320544
申请日：2019-12-19
发明人： Margarethus Marius PAULIDES , Anne Lise ABDEL-ALIM-VAN DEN BERG , Iemkje A. RUITER , Nina BOGERD , Gerard Cornelis VAN RHOON
IPC分类号： A61F7/00
摘要： During hyperthermia treatment of the head and neck area a conventional water bolus, used in such treatment for guiding electromagnetic waves and cooling the patient's skin, may collapse onto the patients face due to the weight and/or pressure of the water inside the water bolus. An insert may be provided inside the water bolus to remedy this, wherein the insert provides additional stiffness and thus resistance against the water's weight and pressure. The insert however should not be too resistant against the shape of the patient, and thus an insert is provided with a first stiffness in a first load direction and a second stiffness in a second load direction, wherein the first stiffness is not equal to the second stiffness.
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公开(公告)号：US20210177936A1
公开(公告)日：2021-06-17
申请号：US17085840
申请日：2020-10-30
发明人： Jacobus Johannes Maria van Dongen , José Alberto Orfao de Matos Correia e Vale , Juan Alejandro Flores Montero , Julia Maria Almeida Parra , Vincent Henricus Johannes Van der Velden , Sebastian Böttcher , Anthonie Willem Langerak , Ester Mejstríková , Tomasz Szczepanski , Matthias Ritgen , Paulo Jorge Monteiro Da Silva Lucio
IPC分类号： A61K38/16 , G01N33/574 , A61K38/17 , A61K39/02 , A61K39/09
摘要： The invention relates to the field of minimal residual disease (MRD) diagnostics, which is progressively more applied for the evaluation of treatment effectiveness in patients with a hematological malignancy, such as B-cell precursor acute lymphoblastic leukemia (BCP-ALL), B-cell chronic lymphocytic leukemia (B-CLL), and multiple myeloma (MM). Provided are unique reagent compositions with carefully selected and thoroughly tested combinations of antibodies, for ≥8-color flow cytometric stainings as well as for 10-color and 12-color flow cyometric stainings, which can reach sensitivities of at least 10−4, even down to 10−5. Also provided are diagnostic kits and methods for detecting MRD.
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