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公开(公告)号：US11485713B2
公开(公告)日：2022-11-01
申请号：US17058481
申请日：2019-05-24
发明人： Han-Jie Zhou , Peter Virsik , Raymond John Andersen , Marianne Dorothy Sadar , Kunzhong Jian , Daniel Andrew Golec
IPC分类号： C07D239/34 , A61K45/06 , C07C69/712 , C07C235/74 , C07C317/24 , C07C317/28 , C07D207/24 , C07D263/56 , C07D295/26 , C07D305/06
摘要： Compounds having a structure of formula (I), (I-A), (Ia)-(Ie), (A)-(E), and (II) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of disorders including prostate cancer are also provided.
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公开(公告)号：US20210198213A1
公开(公告)日：2021-07-01
申请号：US17058481
申请日：2019-05-24
发明人： Han-Jie Zhou , Peter Virsik , Raymond John Andersen , Marianne Dorothy Sadar , Kunzhong Jian , Daniel Andrew Golec
IPC分类号： C07D239/34 , C07C317/28 , C07D305/06 , C07D295/26 , C07C317/24 , C07C69/712 , C07D263/56 , C07D207/24 , C07C235/74 , A61K45/06
摘要： Compounds having a structure of formula (I), (I-A), (Ia)-(Ie), (A)-(E), and (II) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of disorders including prostate cancer are also provided.
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公开(公告)号：US11142508B2
公开(公告)日：2021-10-12
申请号：US16848061
申请日：2020-04-14
发明人： Raymond J. Andersen , Marianne Dorothy Sadar , Kunzhong Jian , Nasrin R. Mawji , Jun Wang , Carmen Adriana Banuelos , Yu-Chi Yang
IPC分类号： C07D295/088 , C07C311/51 , C07C69/28 , C07C233/18 , C07C311/04 , A61K31/09 , A61K31/10 , A61K31/145 , A61K31/4164 , A61K31/5375 , A61K45/06 , C07C43/23 , C07C317/18 , C07C317/22 , C07C317/28 , C07D233/60
摘要： Compounds having a structure of Formula I or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, and X, are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.
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公开(公告)号：US20210387957A1
公开(公告)日：2021-12-16
申请号：US17404589
申请日：2021-08-17
发明人： Raymond J. Andersen , Marianne Dorothy Sadar , Kunzhong Jian , Nasrin R. Mawji , Jun Wang , Carmen Adriana Banuelos , Yu-Chi Yang
IPC分类号： C07D295/088 , C07C311/51 , C07C69/28 , C07C233/18 , C07C311/04 , A61K31/09 , A61K31/10 , A61K31/145 , A61K31/4164 , A61K31/5375 , A61K45/06 , C07C43/23 , C07C317/18 , C07C317/22 , C07C317/28 , C07D233/60
摘要： Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, and X, are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.
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公开(公告)号：US20200317628A1
公开(公告)日：2020-10-08
申请号：US16848061
申请日：2020-04-14
发明人： Raymond J. Andersen , Marianne Dorothy Sadar , Kunzhong Jian , Nasrin R. Mawji , Jun Wang , Carmen Adriana Banuelos , Yu-Chi Yang
IPC分类号： C07D295/088 , C07C311/51 , C07C69/28 , C07C233/18 , C07C311/04 , A61K31/09 , A61K31/10 , A61K31/145 , A61K31/4164 , A61K31/5375 , A61K45/06 , C07C43/23 , C07C317/18 , C07C317/22 , C07C317/28 , C07D233/60
摘要： Compounds having a structure of Formula I or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, and X, are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.
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公开(公告)号：US20210100757A1
公开(公告)日：2021-04-08
申请号：US17116070
申请日：2020-12-09
发明人： Raymond John Andersen , Kunzhong Jian , Marianne Dorothy Sadar , Nasrin R. Mawji , Carmen Adriana Banuelos
IPC分类号： A61K31/09 , C07C43/23 , C07C69/18 , A61K45/06 , A61K31/047 , C07C43/225
摘要： Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, L1, L2, L3, X, a, b, c, n, and m are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity and uses as therapeutics as well as methods for treatment of subjects in need thereof, including prostate cancer are also provided.
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公开(公告)号：US20200325106A1
公开(公告)日：2020-10-15
申请号：US16864479
申请日：2020-05-01
发明人： Raymond John Andersen , Javier Garcia Fernandez , Kunzhong Jian , Marianne Dorothy Sadar , Nasrin R. Mawji , Carmen Adriana Banuelos
IPC分类号： C07D249/04 , A61K45/06 , C07D233/60 , A61K31/4164 , A61K31/4192 , A61K31/5375 , A61K51/04 , C07D295/088 , C07B59/00 , C07D265/30 , A61P35/00 , C07D295/084
摘要： Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, X, n1, n2, and n3 are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.
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公开(公告)号：US20220267283A1
公开(公告)日：2022-08-25
申请号：US17729780
申请日：2022-04-26
发明人： Raymond John Andersen , Javier Garcia Fernandez , Kunzhong Jian , Marianne Dorothy Sadar , Nasrin R. Mawji , Carmen Adriana Banuelos
IPC分类号： C07D249/04 , A61K45/06 , C07D233/60 , A61K31/4164 , A61K31/4192 , A61K31/5375 , A61K51/04 , C07D295/088 , C07B59/00 , C07D265/30 , A61P35/00 , C07D295/084
摘要： Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, X, n1, n2, and n3 are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.
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公开(公告)号：US11345670B2
公开(公告)日：2022-05-31
申请号：US16864479
申请日：2020-05-01
发明人： Raymond John Andersen , Javier Garcia Fernandez , Kunzhong Jian , Marianne Dorothy Sadar , Nasrin R. Mawji , Carmen Adriana Banuelos
IPC分类号： C07D249/04 , A61K45/06 , C07D233/60 , A61K31/4164 , A61K31/4192 , A61K31/5375 , A61K51/04 , C07D295/088 , C07B59/00 , C07D265/30 , A61P35/00 , C07D295/084
摘要： Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, X, n1, n2, and n3 are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.
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公开(公告)号：US10654811B2
公开(公告)日：2020-05-19
申请号：US15543389
申请日：2016-01-13
发明人： Raymond John Andersen , Javier Garcia Fernandez , Kunzhong Jian , Marianne Dorothy Sadar , Nasrin R. Mawji , Carmen Adriana Banuelos
IPC分类号： C07D249/04 , A61K45/06 , C07D233/60 , A61K31/4164 , A61K31/4192 , A61K31/5375 , A61K51/04 , C07D295/088 , C07B59/00 , C07D265/30 , A61P35/00 , C07D295/084
摘要： Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, X, n1, n2, and n3 are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.
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