公开(公告)号：US20230303778A1

公开(公告)日：2023-09-28

申请号：US18205122

申请日：2023-06-02

Applicant: ETH ZURICH

Inventor： Jean-Christophe Leroux ,  Simon Matoori ,  Olha Voznyuk Wuerthinger

IPC: C08G81/02 ,  B01J13/08 ,  C08K5/19 ,  C08K5/353 ,  C08K5/42 ,  G01N33/84 ,  G01N33/68 ,  B01J13/12 ,  C09K11/06

CPC classification number: C08G81/025 ,  B01J13/08 ,  C08K5/19 ,  C08K5/353 ,  C08K5/42 ,  G01N33/84 ,  G01N33/689 ,  B01J13/12 ,  C09K11/06 ,  G01N2800/085 ,  A61K9/1273

Abstract: The present invention provides polymersomes comprising amphiphilic block-copolymers and their use to quantify ammonia in samples (e.g., body fluid samples). More particularly, it provides a polymersome comprising (a) a membrane, which comprises a block copolymer of poly(styrene) (PS) and poly(ethylene oxide) (PEO), wherein the PS/PEO molecular weight ratio is higher than 1.0 and lower than 4.0; and (b) a core which encloses an acid and at least one pH-sensitive dye. Compositions, strips and kits comprising the polymersomes are also provided along with methods of quantifying ammonia in a sample using the polymersomes, compositions and kit.

公开(公告)号：US20200283583A1

公开(公告)日：2020-09-10

申请号：US16645763

申请日：2018-09-10

Applicant: ETH ZURICH

Inventor： Jean-Christophe Leroux ,  Simon Matoori ,  Olha Voznyuk Wuerthinger

IPC: C08G81/02 ,  G01N33/84 ,  C08K5/19 ,  C08K5/42 ,  C08K5/353 ,  B01J13/08

Abstract: The present invention provides polymersomes comprising amphiphilic block-copolymers and their use to quantify ammonia in samples (e.g., body fluid samples). More particularly, it provides a polymersome comprising (a) a membrane, which comprises a block copolymer of poly(styrene) (PS) and poly(ethylene oxide) (PEO), wherein the PS/PEO molecular weight ratio is higher than 1.0 and lower than 4.0; and (b) a core which encloses an acid and at least one pH-sensitive dye. Compositions, strips and kits comprising the polymersomes are also provided along with methods of quantifying ammonia in a sample using the polymersomes, compositions and kit.

公开(公告)号：US11999829B2

公开(公告)日：2024-06-04

申请号：US18123905

申请日：2023-03-20

Applicant: ETH ZURICH

Inventor： Jean-Christophe Leroux ,  Simon Matoori ,  Olha Voznyuk Wuerthinger

IPC: C08G81/02 ,  A61K9/127 ,  B01J13/08 ,  B01J13/12 ,  C08K5/19 ,  C08K5/353 ,  C08K5/42 ,  C09K11/06 ,  G01N33/68 ,  G01N33/84

CPC classification number: C08G81/025 ,  B01J13/08 ,  B01J13/12 ,  C08K5/19 ,  C08K5/353 ,  C08K5/42 ,  C09K11/06 ,  G01N33/689 ,  G01N33/84 ,  A61K9/1273 ,  B01J13/125 ,  G01N2800/085

Abstract: The present invention provides polymersomes comprising amphiphilic block-copolymers and their use to quantify ammonia in samples (e.g., body fluid samples). More particularly, it provides a polymersome comprising (a) a membrane, which comprises a block copolymer of poly(styrene) (PS) and poly(ethylene oxide) (PEO), wherein the PS/PEO molecular weight ratio is higher than 1.0 and lower than 4.0; and (b) a core which encloses an acid and at least one pH-sensitive dye. Compositions, strips and kits comprising the polymersomes are also provided along with methods of quantifying ammonia in a sample using the polymersomes, compositions and kit.

公开(公告)号：US11713376B2

公开(公告)日：2023-08-01

申请号：US16645763

申请日：2018-09-10

Applicant: ETH ZURICH

Inventor： Jean-Christophe Leroux ,  Simon Matoori ,  Olha Voznyuk Wuerthinger

IPC: C08G81/02 ,  B01J13/08 ,  C08K5/19 ,  C08K5/353 ,  C08K5/42 ,  G01N33/84 ,  G01N33/68 ,  B01J13/12 ,  C09K11/06 ,  A61K9/127

CPC classification number: C08G81/025 ,  B01J13/08 ,  B01J13/12 ,  C08K5/19 ,  C08K5/353 ,  C08K5/42 ,  C09K11/06 ,  G01N33/689 ,  G01N33/84 ,  A61K9/1273 ,  B01J13/125 ,  G01N2800/085

Abstract: The present invention provides polymersomes comprising amphiphilic block-copolymers and their use to quantify ammonia in samples (e.g., body fluid samples). More particularly, it provides a polymersome comprising (a) a membrane, which comprises a block copolymer of poly(styrene) (PS) and poly(ethylene oxide) (PEO), wherein the PS/PEO molecular weight ratio is higher than 1.0 and lower than 4.0; and (b) a core which encloses an acid and at least one pH-sensitive dye. Compositions, strips and kits comprising the polymersomes are also provided along with methods of quantifying ammonia in a sample using the polymersomes, compositions and kit.

公开(公告)号：US20230220165A1

公开(公告)日：2023-07-13

申请号：US18123905

申请日：2023-03-20

Applicant: ETH ZURICH

Inventor： Jean-Christophe Leroux ,  Simon Matoori ,  Olha Voznyuk Wuerthinger

IPC: A61K9/127 ,  G01N33/84 ,  C09K11/06 ,  C08K5/42 ,  B01J13/08 ,  B01J13/12

CPC classification number: A61K9/1273 ,  G01N33/84 ,  C09K11/06 ,  C08K5/42 ,  B01J13/08 ,  B01J13/12

Abstract: The present invention provides polymersomes comprising amphiphilic block-copolymers and their use to quantify ammonia in samples (e.g., body fluid samples). More particularly, it provides a polymersome comprising (a) a membrane, which comprises a block copolymer of poly(styrene) (PS) and poly(ethylene oxide) (PEO), wherein the PS/PEO molecular weight ratio is higher than 1.0 and lower than 4.0; and (b) a core which encloses an acid and at least one pH-sensitive dye. Compositions, strips and kits comprising the polymersomes are also provided along with methods of quantifying ammonia in a sample using the polymersomes, compositions and kit.