公开(公告)号：US11660372B2

公开(公告)日：2023-05-30

申请号：US17592312

申请日：2022-02-03

Applicant: EVOLVED BY NATURE, INC.

Inventor： Gregory H. Altman ,  Peng Xu ,  Erlei Jin

IPC: A61L27/26 ,  A61L27/52

CPC classification number: A61L27/26 ,  A61L27/52 ,  A61L2300/402 ,  A61L2400/06 ,  A61L2430/34

Abstract: Hyaluronic acid and silk protein fragments based tissue fillers and methods of using the same are provided herein.

公开(公告)号：US12296067B2

公开(公告)日：2025-05-13

申请号：US17414752

申请日：2019-12-19

Applicant: Evolved by Nature, Inc.

Inventor： Gregory H. Altman ,  Rebecca L. Lacouture ,  Peng Xu ,  Erlei Jin ,  Carlos J. Bosques ,  Patrick Yacono ,  Patrik Johansson

IPC: A61L27/26 ,  A61K8/64 ,  A61K8/73 ,  A61K8/86 ,  A61L27/36 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61Q19/08

Abstract: Hyaluronic acid and silk fibroin or silk fibroin fragments tissue fillers and methods of making and using the same are provided herein. In some embodiments, the disclosure relates to a biocompatible tissue filler comprising silk fibroin or silk fibroin fragments, hyaluronic acid (HA), and polyethylene glycol (PEG) and/or polypropylene glycol (PPG), wherein a portion of the HA is modified or crosslinked by one or more linker moieties comprising one or more of polyethylene glycol (PEG), polypropylene glycol (PPG), and a secondary alcohol, wherein the linker moieties are attached to the HA at one end of the linker.

公开(公告)号：US20230338614A1

公开(公告)日：2023-10-26

申请号：US18306965

申请日：2023-04-25

Applicant: Evolved by Nature, Inc.

Inventor： Gregory H. Altman ,  Peng Xu ,  Erlei Jin

IPC: A61L27/26 ,  A61L27/52 ,  A61L27/22 ,  A61L27/20

CPC classification number: A61L27/26 ,  A61L27/20 ,  A61L27/227 ,  A61L27/52 ,  A61L2300/402 ,  A61L2400/06 ,  A61L2430/34

Abstract: Hyaluronic acid and silk protein fragments based tissue fillers and methods of using the same are provided herein.