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公开(公告)号：US3925152A
公开(公告)日：1975-12-09
申请号：US42373073
申请日：1973-12-11
Applicant: EXPLOATERINGS AB TBF
Inventor： PORATH JERKER OLOF , JANSON JAN-CHRISTER
CPC classification number: C12N7/00 , B01J20/22 , B01J43/00 , B01J47/014 , C12N2770/18051
Abstract: The present invention relates to a method of separating a mixture of charged colloidal particles, e.g. virus variants by bringing the mixture to pass a bed of an adsorbent. The invention is mainly characterized in that the adsorbent is constituted of an insoluble, organic polymer containing amphoteric substituents composed of both basic nitrogen-containing groups and carboxylate or sulphonate groups. The proportion between the basic and the acid groups is simple and stoichiometric, whereby said charged particles are allowed to migrate at different speeds depending on the strength of the reciprocal interaction between the charged particles and the substituents in said adsorbent and are selectively adsorbed by said adsorbent.
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