公开(公告)号：US20110076335A1

公开(公告)日：2011-03-31

申请号：US12828189

申请日：2010-06-30

申请人： Ed Yaworski ,  Stephen Reid ,  James Heyes ,  Adam Judge ,  Ian MacLachlan

发明人： Ed Yaworski ,  Stephen Reid ,  James Heyes ,  Adam Judge ,  Ian MacLachlan

IPC分类号： A61K31/713 ,  A61K9/50 ,  A61K31/7088 ,  A61P35/00

CPC分类号： A61K47/44 ,  A61K9/0019 ,  A61K9/1272 ,  A61K31/713 ,  A61K47/543 ,  C12N15/111 ,  C12N15/1137 ,  C12N15/88 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/344 ,  C12N2320/30 ,  C12N2320/32 ,  C12N2310/3521

摘要： The present invention provides novel, serum-stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles. More particularly, the present invention provides serum-stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (e.g., one or more interfering RNA molecules), methods of making the SNALP, and methods of delivering and/or administering the SNALP (e.g., for the treatment of cancer). In particular embodiments, the present invention provides tumor-directed lipid particles that preferentially target solid tumors. The tumor-directed formulations of the present invention are capable of preferentially delivering a payload such as a nucleic acid to cells of solid tumors compared to non-cancerous cells.

摘要翻译： 本发明提供包含一种或多种活性剂或治疗剂的新型血清稳定脂质颗粒，制备脂质颗粒的方法，以及递送和/或施用脂质颗粒的方法。 更具体地说，本发明提供了包含核酸（例如一个或多个干扰RNA分子）的血清稳定的核酸 - 脂质颗粒（SNALP），制备SNALP的方法，以及递送和/或施用SNALP的方法 例如，用于治疗癌症）。 在具体实施方案中，本发明提供优先靶向实体瘤的肿瘤指导的脂质颗粒。 与非癌细胞相比，本发明的肿瘤引导制剂能够优先将有效载荷例如核酸递送至实体瘤细胞。

公开(公告)号：US20130022649A1

公开(公告)日：2013-01-24

申请号：US13513548

申请日：2010-12-01

申请人： Ed Yaworski ,  James Heyes ,  Adam Judge ,  Stephen Reid ,  Ian MacLachlan

发明人： Ed Yaworski ,  James Heyes ,  Adam Judge ,  Stephen Reid ,  Ian MacLachlan

IPC分类号： A61K31/7088 ,  A61K9/14 ,  B82Y5/00

CPC分类号： C12N15/111 ,  A61K9/1271 ,  A61K9/1272 ,  A61K47/183 ,  C12N2320/32

摘要： The present invention provides methods of preventing, decreasing, or inhibiting the degradation of cationic lipids and/or active agents (e.g., therapeutic nucleic acids) present in lipid particles, compositions comprising lipid particles stabilized by these methods, methods of making these lipid particles, and methods of delivering and/or administering these lipid particles, e.g., for the treatment of a disease or disorder.

摘要翻译： 本发明提供了防止，降低或抑制存在于脂质颗粒中的阳离子脂质和/或活性剂（例如，治疗性核酸）的降解的方法，包含通过这些方法稳定的脂质颗粒的组合物，制备这些脂质颗粒的方法， 以及递送和/或施用这些脂质颗粒的方法，例如用于治疗疾病或病症。

公开(公告)号：US20130122104A1

公开(公告)日：2013-05-16

申请号：US13566952

申请日：2012-08-03

申请人： Ed Yaworski ,  Stephen Reid ,  James Heyes ,  Adam Judge ,  Ian MacLachlan

发明人： Ed Yaworski ,  Stephen Reid ,  James Heyes ,  Adam Judge ,  Ian MacLachlan

IPC分类号： A61K47/44

CPC分类号： A61K47/44 ,  A61K9/0019 ,  A61K9/1272 ,  A61K31/713 ,  A61K47/543 ,  C12N15/111 ,  C12N15/1137 ,  C12N15/88 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/344 ,  C12N2320/30 ,  C12N2320/32 ,  C12N2310/3521

摘要： The present invention provides novel, serum-stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles. More particularly, the present invention provides serum-stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (e.g., one or more interfering RNA molecules), methods of making the SNALP, and methods of delivering and/or administering the SNALP (e.g., for the treatment of cancer). In particular embodiments, the present invention provides tumor-directed lipid particles that preferentially target solid tumors. The tumor-directed formulations of the present invention are capable of preferentially delivering a payload such as a nucleic acid to cells of solid tumors compared to non-cancerous cells.

公开(公告)号：US08283333B2

公开(公告)日：2012-10-09

申请号：US12828189

申请日：2010-06-30

申请人： Ed Yaworski ,  Stephen Reid ,  James Heyes ,  Adam Judge ,  Ian MacLachlan

发明人： Ed Yaworski ,  Stephen Reid ,  James Heyes ,  Adam Judge ,  Ian MacLachlan

IPC分类号： C12N15/11 ,  C07H21/02 ,  A61K9/127

CPC分类号： A61K47/44 ,  A61K9/0019 ,  A61K9/1272 ,  A61K31/713 ,  A61K47/543 ,  C12N15/111 ,  C12N15/1137 ,  C12N15/88 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/344 ,  C12N2320/30 ,  C12N2320/32 ,  C12N2310/3521

摘要： The present invention provides novel, serum-stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles. More particularly, the present invention provides serum-stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (e.g., one or more interfering RNA molecules), methods of making the SNALP, and methods of delivering and/or administering the SNALP (e.g., for the treatment of cancer). In particular embodiments, the present invention provides tumor-directed lipid particles that preferentially target solid tumors. The tumor-directed formulations of the present invention are capable of preferentially delivering a payload such as a nucleic acid to cells of solid tumors compared to non-cancerous cells.

摘要翻译： 本发明提供包含一种或多种活性剂或治疗剂的新型血清稳定脂质颗粒，制备脂质颗粒的方法，以及递送和/或施用脂质颗粒的方法。 更具体地说，本发明提供了包含核酸（例如一个或多个干扰RNA分子）的血清稳定的核酸 - 脂质颗粒（SNALP），制备SNALP的方法，以及递送和/或施用SNALP的方法 例如，用于治疗癌症）。 在具体实施方案中，本发明提供优先靶向实体瘤的肿瘤指导的脂质颗粒。 与非癌细胞相比，本发明的肿瘤引导制剂能够优先将有效载荷例如核酸递送至实体瘤细胞。

公开(公告)号：US09322248B2

公开(公告)日：2016-04-26

申请号：US13991857

申请日：2011-11-17

申请人： Charles S. Yeh ,  Michael D. Barry ,  Michael T. Hecker ,  Tracy J. Moffett ,  Jon Blacklock ,  David C. Haeberle ,  Patrick C. Hyde ,  Iain M. Macleod ,  Lee Mercer ,  Stephen Reid ,  Andrew J. Elrick

发明人： Charles S. Yeh ,  Michael D. Barry ,  Michael T. Hecker ,  Tracy J. Moffett ,  Jon Blacklock ,  David C. Haeberle ,  Patrick C. Hyde ,  Iain M. Macleod ,  Lee Mercer ,  Stephen Reid ,  Andrew J. Elrick

IPC分类号： E21B43/04 ,  E21B43/08 ,  E21B43/14 ,  E21B33/12 ,  E21B34/06 ,  E21B34/14 ,  E21B33/124

CPC分类号： E21B43/04 ,  E21B33/124 ,  E21B34/063 ,  E21B34/14 ,  E21B43/045 ,  E21B43/08 ,  E21B43/14

摘要： Completing a wellbore in a subsurface formation with packer assembly having first mechanically-set packer as first zonal isolation tool, and second zonal isolation tool comprises internal bore for receiving production fluids, and alternate flow channels. First packer has alternate flow channels around inner mandrel, and sealing element external to inner mandrel and includes operatively connecting packer assembly to a sand screen, and running into wellbore. First packer set by actuating sealing element into engagement with surrounding open-hole portion of the wellbore. Thereafter, injecting a gravel slurry and further injecting the gravel slurry through the alternate flow channels to allow it to bypass the sealing element, resulting in a gravel packed wellbore within an annular region between sand screen and surrounding formation below packer assembly.

摘要翻译： 用具有第一机械设置的封隔器作为第一区域隔离工具的封隔器组件完成地下构造中的井筒，并且第二区域隔离工具包括用于接收生产流体的内孔和交替的流动通道。 第一封隔器在内心轴周围具有交替的流动通道，以及在内心轴外部的密封元件，并且包括将封隔器组件可操作地连接到砂筛并进入井眼。 第一封隔器通过致动密封元件与井眼的周围露孔部分接合来设定。 此后，注入砾石浆料，并通过交替的流动通道进一步注入砾石浆料，以允许其绕过密封元件，从而在砂筛和封隔器组件下方的周围地层之间的环形区域内产生砾石填充的井筒。

公开(公告)号：US20110284208A1

公开(公告)日：2011-11-24

申请号：US13145473

申请日：2010-01-22

申请人： Iain MacLeod ,  Andrew Elrick ,  Stephen Reid

发明人： Iain MacLeod ,  Andrew Elrick ,  Stephen Reid

IPC分类号： E21B19/00

CPC分类号： E21B41/00 ,  E21B17/07 ,  E21B23/01 ,  E21B23/06 ,  E21B33/129

摘要： A lock ring for use as a one way movement restrictor between two telescopingly arranged tubulars to permit movement in one direction and prevent movement in the other direction of one tubular relative to the other tubular is described. The lock ring comprised: a profile having one or more formations formed on the outer circumference for engagement with a suitable formation profile formed on the inner circumference of the outer telescopic tubular; and one or more teeth formed on its inner circumference, the teeth being adapted to dig into the outer surface of the inner telescopic member. An apparatus and a method for setting a downhole anchor is also disclosed.

摘要翻译： 一种锁环，用于在两个可伸缩布置的管之间用作单向运动限制器，以允许沿一个方向运动并防止在一个管的相对于另一个管的另一个方向上运动。 锁定环包括：具有形成在外圆周上的一个或多个结构的轮廓，用于与形成在外伸缩管的内圆周上的合适的地层轮廓接合; 并且在其内圆周上形成有一个或多个齿，所述齿适于挖入内伸缩构件的外表面。 还公开了一种用于设置井下锚杆的装置和方法。

公开(公告)号：US11180971B2

公开(公告)日：2021-11-23

申请号：US14416909

申请日：2012-07-25

申请人： Alan Craigon ,  Philip C G Egleton ,  Stephen Reid ,  Andrew John Elrick ,  Santiago Galvez Porta

发明人： Alan Craigon ,  Philip C G Egleton ,  Stephen Reid ,  Andrew John Elrick ,  Santiago Galvez Porta

IPC分类号： E21B33/126 ,  E21B33/128 ,  E21B23/06 ,  E21B43/25 ,  E21B33/12 ,  E21B33/136

摘要： A flow restrictor for restricting flow in an annulus, the flow restrictor comprising a body and a restrictor assembly mounted on the body, wherein the restrictor assembly is actuatable between a run-in configuration and a set configuration in which at least a portion of the restrictor assembly is radially splayed to thereby substantially restrict flow in the annulus, and wherein the flow restrictor is actuatable by fluid flow over the restrictor assembly above a threshold flow rate to actuate the restrictor assembly from the run-in configuration to the set configuration.

公开(公告)号：US09303485B2

公开(公告)日：2016-04-05

申请号：US13990803

申请日：2011-12-06

申请人： Michael T. Hecker ,  Michael D. Barry ,  Petrus A. J. Stevens ,  David A. Howell ,  Charles S. Yeh ,  Iain M. Macleod ,  Lee Mercer ,  Stephen Reid ,  Andrew J. Elrick

发明人： Michael T. Hecker ,  Michael D. Barry ,  Petrus A. J. Stevens ,  David A. Howell ,  Charles S. Yeh ,  Iain M. Macleod ,  Lee Mercer ,  Stephen Reid ,  Andrew J. Elrick

IPC分类号： E21B33/13 ,  E21B33/12 ,  E21B43/04

CPC分类号： E21B33/13 ,  E21B33/12 ,  E21B43/045

摘要： Method for completing a wellbore in a subsurface formation includes providing a sand control device representing one or more joints of sand screens, and a packer assembly along the joints with at least one mechanically-set packer with at least one alternate flow channel therein. Running the packer assembly and connected sand screen into the wellbore, setting a mechanically-set packer into engagement with the surrounding wellbore, injecting gravel slurry into the wellbore to form a gravel pack. An elongated isolation string is run into the sand control device across the packer assembly with valves that serve as an inflow control device. Thereafter, seals are activated around the isolation string and adjacent the packer assembly. A zonal isolation apparatus allows flow control to be provided above and below packer assembly.

摘要翻译： 在地下地层中完成井眼的方法包括：提供一个表示沙子筛网的一个或多个接头的砂控制装置，以及一个具有至少一个机械设置的封隔器的封隔器组件，所述封隔器在其中具有至少一个交替的流动通道。 将封隔器组件和连接的砂筛运行到井筒中，将机械设置的封隔器设置成与周围的井筒接合，将砾石浆料注入井筒中以形成砾石填料。 细长的隔离串通过封隔器组件进入砂控制装置，该阀具有用作流入控制装置的阀。 此后，密封件围绕隔离柱并且邻近封隔器组件被致动。 区域隔离装置允许在封隔器组件的上方和下方设置流量控制。

公开(公告)号：US20130248179A1

公开(公告)日：2013-09-26

申请号：US13991852

申请日：2011-11-17

申请人： Charles S. Yeh ,  Michael D. Barry ,  Michael T. Hecker ,  Tracy J. Moffett ,  Jon Blacklock ,  David C. Haeberle ,  Patrick C. Hyde ,  Iain M. Macleod ,  Lee Mercer ,  Stephen Reid ,  Andrew J. Elrick

发明人： Charles S. Yeh ,  Michael D. Barry ,  Michael T. Hecker ,  Tracy J. Moffett ,  Jon Blacklock ,  David C. Haeberle ,  Patrick C. Hyde ,  Iain M. Macleod ,  Lee Mercer ,  Stephen Reid ,  Andrew J. Elrick

IPC分类号： E21B43/04 ,  E21B43/16 ,  E21B43/00 ,  E21B33/12 ,  E21B33/126

CPC分类号： E21B43/04 ,  E21B23/06 ,  E21B33/12 ,  E21B33/124 ,  E21B33/126 ,  E21B33/1295 ,  E21B43/00 ,  E21B43/16

摘要： Apparatus and method for completing a wellbore including providing a packer having an inner mandrel, alternate flow channels along the inner mandrel, and a sealing element external to the inner mandrel, including connecting packer to tubular body, then running the packer and connected tubular body into the wellbore. In one aspect, the packer and connected tubular body may be placed along an open-hole portion of the wellbore. Tubular body may be a sand screen, with the sand screen comprising a base pipe, a surrounding filter medium, and alternate flow channels. The method includes setting a packer and injecting a gravel slurry into an annular region formed between the tubular body and the surrounding wellbore, and then further injecting the gravel slurry through the alternate flow channels to allow the gravel slurry to at least partially bypass sealing element of the packer.

摘要翻译： 用于完成井眼的装置和方法，包括提供具有内心轴的封隔器，沿着内心轴的交替流动通道，以及在内心轴外部的密封元件，包括将封隔器连接到管状体，然后将封隔器和连接的管状体运行到 井筒。 在一个方面，封隔器和连接的管状体可以沿着井孔的开孔部分放置。 管状体可以是砂筛，其中筛网包括基管，周围的过滤介质和交替的流动通道。 该方法包括设置封隔器并将砾石浆料注入形成在管体和周围井眼之间的环形区域中，然后通过交替的流动通道进一步注入砾石浆料，以使砾石浆料至少部分地绕过 封隔器

公开(公告)号：US20130248178A1

公开(公告)日：2013-09-26

申请号：US13990803

申请日：2011-12-06

申请人： Michael T. Hecker ,  Michael D. Barry ,  Petrus A. J. Stevens ,  David A. Howell ,  Charles S. Yeh ,  Iain M. Macleod ,  Lee Mercer ,  Stephen Reid ,  Andew J. Elrick

发明人： Michael T. Hecker ,  Michael D. Barry ,  Petrus A. J. Stevens ,  David A. Howell ,  Charles S. Yeh ,  Iain M. Macleod ,  Lee Mercer ,  Stephen Reid ,  Andew J. Elrick

IPC分类号： E21B33/13

CPC分类号： E21B33/13 ,  E21B33/12 ,  E21B43/045

摘要： Method for completing a wellbore in a subsurface formation includes providing a sand control device representing one or more joints of sand screens, and a packer assembly along the joints with at least one mechanically-set packer with at least one alternate flow channel therein. Running the packer assembly and connected sand screen into the wellbore, setting a mechanically-set packer into engagement with the surrounding wellbore, injecting gravel slurry into the wellbore to form a gravel pack. An elongated isolation string is run into the sand control device across the packer assembly with valves that serve as an inflow control device. Thereafter, seals are activated around the isolation string and adjacent the packer assembly. A zonal isolation apparatus allows flow control to be provided above and below packer assembly.

摘要翻译： 在地下地层中完成井眼的方法包括：提供一个表示沙子筛网的一个或多个接头的砂控制装置，以及一个具有至少一个机械设置的封隔器的封隔器组件，所述封隔器在其中具有至少一个交替的流动通道。 将封隔器组件和连接的砂筛运行到井筒中，将机械设置的封隔器设置成与周围的井筒接合，将砾石浆料注入井筒中以形成砾石填料。 细长的隔离串通过封隔器组件进入砂控制装置，该阀具有用作流入控制装置的阀。 此后，密封件围绕隔离柱并且邻近封隔器组件被致动。 区域隔离装置允许在封隔器组件的上方和下方设置流量控制。