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1.发明授权Acetate resistance in yeast based on introduction of a mutant HAA1 allele 有权基于引入突变HAA1等位基因的酵母中的醋酸耐药性公开(公告)号：US09085781B2
公开(公告)日：2015-07-21
申请号：US13947338
申请日：2013-07-22
申请人： Edeniq, Inc.
发明人： Kenneth Zahn , Sandra Jacobson
IPC分类号： C12P7/06 , C12N15/81 , C12P7/10 , C07K14/395 , C12N1/22
摘要： Improved haa1 transcriptional regulatory proteins, polynucleotides encoding improved haa1 transcriptional regulatory proteins and vectors and cells thereof are provided, as well as methods for converting a cellulose-containing biomass feedstock to ethanol using improved haa1 transcriptional regulatory proteins and cells expressing heterologous haa1 transcriptional regulatory proteins as disclosed herein.
摘要翻译： 提供了改进的haa1转录调节蛋白，编码改进的haa1转录调节蛋白的多核苷酸和载体及其细胞，以及使用改进的haa1转录调节蛋白和表达异源haa1转录调节蛋白的细胞将含纤维素的生物质原料转化为乙醇的方法， 这里公开。
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公开(公告)号：US11492649B2
公开(公告)日：2022-11-08
申请号：US16360408
申请日：2019-03-21
申请人： Edeniq, Inc.
发明人： Deepak Singh , Sandra Jacobson , Kris Ramos , Prachand Shrestha
摘要： The present disclosure provides methods for generating sugars from a cellulosic biomass. The methods combine treatment of the biomass using a high-shear milling device and saccharification of the biomass to partially hydrolyze the biomass. The biomass can be saccharified either after or simultaneously with the high-shear milling treatement. The partially hydrolyzed biomass is then separated into a solids stream with saccharification enzymes, and a liquid stream with sugars. The solids stream and associated enzymes are further incubated under saccharification conditions to produce additional sugars, or are recycled and added to fresh biomass, which is saccharified under high-shear milling conditions. The methods result in improved conversion of cellulosic biomass to glucose.
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3.发明申请公开(公告)号：US20160304849A1
公开(公告)日：2016-10-20
申请号：US15022903
申请日：2014-09-16
申请人： EDENIQ, INC.
发明人： Lan Sun , Ngim Muy Ung Ferrell , Deepak Singh , Jennifer Headman , Mei-Hua Chu , Michael Guerini , Sandra Jacobson
CPC分类号： C12N9/2445 , C12N15/81 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01021 , Y02E50/16
摘要： Described herein are beta-glucosidase enzymes that have improved beta-glucosidase activity compared to a control beta-glucosidase enzyme. The improved beta-glucosidase enzymes are useful for converting a cellulosic biomass to fermentable sugars such as glucose. Also described are isolated polynucleotides that encode polypeptides having improved beta-glucosidase activity, expression cassettes for expressing the improved beta-glucosidase polypeptides, and cells, such as yeast cells, transformed with the expression cassettes.
摘要翻译： 本文描述的是与对照β-葡糖苷酶相比具有改善的β-葡糖苷酶活性的β-葡糖苷酶。 改进的β-葡糖苷酶可用于将纤维素生物质转化为可发酵糖如葡萄糖。 还描述了编码具有改善的β-葡糖苷酶活性的多肽的分离的多核苷酸，用于表达改良的β-葡糖苷酶多肽的表达盒和用表达盒转化的细胞，例如酵母细胞。
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公开(公告)号：US20160160252A1
公开(公告)日：2016-06-09
申请号：US14907212
申请日：2014-07-24
申请人： EDENIQ, INC.
发明人： John Zhang , Sandra Jacobson , Kristoffer Ramos , Mrugesh Patel , James Kacmar , Daniel Michalopoulos
IPC分类号： C12P19/14 , C12P19/02 , C08F126/10 , C08F116/06 , C08G65/08 , C08G65/34
CPC分类号： C12P19/14 , B01D61/145 , B01D2311/08 , B01D2311/25 , B01D2315/10 , C08F116/06 , C08F126/10 , C08G65/08 , C08G65/34 , C12P19/02 , B01D2311/04
摘要： Methods and systems for increasing the yield of sugars from a biomass, such as a lignocellulosic biomass, are described. A non-ionic organic polymer is contacted with the biomass during the saccharification reaction, and the hydrolyzed mixture is separated using a filter into a permeate and a retentate, where the non-ionic organic polymer is present in the retentate. The retentate with the polymer is recycled to the hydrolysis mixture, which increased the yield of sugars using less saccharification enzymes. The methods thus allow for increased cost savings by reducing the amount of enzymes required to convert the biomass to sugars.
摘要翻译： 描述了用于提高来自生物质如木质纤维素生物质的糖的产率的方法和系统。 在糖化反应期间，非离子有机聚合物与生物质接触，并且使用过滤器将水解的混合物分离成渗透物和渗余物，其中非离子有机聚合物存在于渗余物中。 将聚合物的保留物再循环到水解混合物中，其使用较少的糖化酶增加了糖的产率。 因此，这些方法允许通过减少将生物质转化为糖所需的酶的量来增加成本节省。
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公开(公告)号：US10077436B2
公开(公告)日：2018-09-18
申请号：US15022903
申请日：2014-09-16
申请人： Edeniq, Inc.
发明人： Lan Sun , Ngim Muy Ung Ferrell , Deepak Singh , Jennifer Headman , Mei-Hua Chu , Michael Guerini , Sandra Jacobson
CPC分类号： C12N9/2445 , C12N15/81 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01021 , Y02E50/16
摘要： Described herein are beta-glucosidase enzymes that have improved beta-glucosidase activity compared to a control beta-glucosidase enzyme. The improved beta-glucosidase enzymes are useful for converting a cellulosic biomass to fermentable sugars such as glucose. Also described are isolated polynucleotides that encode polypeptides having improved beta-glucosidase activity, expression cassettes for expressing the improved beta-glucosidase polypeptides, and cells, such as yeast cells, transformed with the expression cassettes.
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公开(公告)号：US20160032339A1
公开(公告)日：2016-02-04
申请号：US14775588
申请日：2014-03-14
申请人： EDENIQ, INC.
发明人： Deepak Singh , Sandra Jacobson , Kris Ramos , Prachand Shrestha
CPC分类号： C12P19/14 , C07H3/04 , C12P7/10 , C12P19/02 , C12P19/12 , C12P2201/00 , C12P2203/00 , C13K1/02 , C13K13/002 , Y02E50/16
摘要： The present disclosure provides methods for generating sugars from a cellulosic biomass. The methods combine treatment of the biomass using a high-shear milling device and saccharification of the biomass to partially hydrolyze the biomass. The biomass can be saccharified either after or simultaneously with the high-shear milling treatement. The partially hydrolyzed biomass is then separated into a solids stream with saccharification enzymes, and a liquid stream with sugars. The solids stream and associated enzymes are further incubated under saccharification conditions to produce additional sugars, or are recycled and added to fresh biomass, which is saccharified under high-shear milling conditions. The methods result in improved conversion of cellulosic biomass to glucose.
摘要翻译： 本公开提供了用于从纤维素生物质产生糖的方法。 该方法结合了使用高剪切研磨装置的生物质处理和生物质的糖化以部分水解生物质。 生物质可以在高剪切研磨处理之后或同时进行糖化。 然后将部分水解的生物质与糖化酶和具有糖的液体流分离成固体物流。 将固体物流和相关酶进一步在糖化条件下孵育以产生额外的糖，或再循环并加入到在高剪切研磨条件下糖化的新鲜生物质中。 该方法导致纤维素生物质转化为葡萄糖。
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7.发明申请公开(公告)号：US20140024095A1
公开(公告)日：2014-01-23
申请号：US13947338
申请日：2013-07-22
发明人： Kenneth Zahn , Sandra Jacobson
摘要： Improved haa1 transcriptional regulatory proteins, polynucleotides encoding improved haa1 transcriptional regulatory proteins and vectors and cells thereof are provided, as well as methods for converting a cellulose-containing biomass feedstock to ethanol using improved haa1 transcriptional regulatory proteins and cells expressing heterologous haa1 transcriptional regulatory proteins as disclosed herein.
摘要翻译： 提供了改进的haa1转录调节蛋白，编码改进的haa1转录调节蛋白的多核苷酸和载体及其细胞，以及使用改进的haa1转录调节蛋白和表达异源haa1转录调节蛋白的细胞将含纤维素的生物质原料转化为乙醇的方法， 这里公开。
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公开(公告)号：US11999985B2
公开(公告)日：2024-06-04
申请号：US17957633
申请日：2022-09-30
申请人： Edeniq, Inc.
发明人： Deepak Singh , Sandra Jacobson , Kris Ramos , Prachand Shrestha
CPC分类号： C12P19/14 , C07H3/04 , C12P7/10 , C12P19/02 , C12P19/12 , C13K1/02 , C13K13/002 , C12P2201/00 , C12P2203/00 , Y02E50/10
摘要： The present disclosure provides methods for generating sugars from a cellulosic biomass. The methods combine treatment of the biomass using a high-shear milling device and saccharification of the biomass to partially hydrolyze the biomass. The biomass can be saccharified either after or simultaneously with the high-shear milling treatment. The partially hydrolyzed biomass is then separated into a solids stream with saccharification enzymes, and a liquid stream with sugars. The solids stream and associated enzymes are further incubated under saccharification conditions to produce additional sugars, or are recycled and added to fresh biomass, which is saccharified under high-shear milling conditions. The methods result in improved conversion of cellulosic biomass to glucose.
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公开(公告)号：US20190276865A1
公开(公告)日：2019-09-12
申请号：US16360408
申请日：2019-03-21
申请人： Edeniq, Inc.
发明人： Deepak Singh , Sandra Jacobson , Kris Ramos , Prachand Shrestha
摘要： The present disclosure provides methods for generating sugars from a cellulosic biomass. The methods combine treatment of the biomass using a high-shear milling device and saccharification of the biomass to partially hydrolyze the biomass. The biomass can be saccharified either after or simultaneously with the high-shear milling treatement. The partially hydrolyzed biomass is then separated into a solids stream with saccharification enzymes, and a liquid stream with sugars. The solids stream and associated enzymes are further incubated under saccharification conditions to produce additional sugars, or are recycled and added to fresh biomass, which is saccharified under high-shear milling conditions. The methods result in improved conversion of cellulosic biomass to glucose.
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公开(公告)号：US10260081B2
公开(公告)日：2019-04-16
申请号：US14775588
申请日：2014-03-14
申请人： Edeniq, Inc.
发明人： Deepak Singh , Sandra Jacobson , Kris Ramos , Prachand Shrestha
摘要： The present disclosure provides methods for generating sugars from a cellulosic biomass. The methods combine treatment of the biomass using a high-shear milling device and saccharification of the biomass to partially hydrolyze the biomass. The biomass can be saccharified either after or simultaneously with the high-shear milling treatment. The partially hydrolyzed biomass is then separated into a solids stream with saccharification enzymes, and a liquid stream with sugars. The solids stream and associated enzymes are further incubated under saccharification conditions to produce additional sugars, or are recycled and added to fresh biomass, which is saccharified under high-shear milling conditions. The methods result in improved conversion of cellulosic biomass to glucose.
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