Apparatus and method for focusing and selecting ions and charged particles at or near atmospheric pressure
    1.
    发明授权
    Apparatus and method for focusing and selecting ions and charged particles at or near atmospheric pressure 失效
    在大气压或接近大气压下聚焦和选择离子和带电粒子的装置和方法

    公开(公告)号:US06784424B1

    公开(公告)日:2004-08-31

    申请号:US10155151

    申请日:2002-05-25

    IPC分类号: H01J4926

    CPC分类号: H01J49/4215

    摘要: The present invention relates to an apparatus and method for focusing, separating, and detecting gas-phase ions using the principles of quadrupole fields, substantially at or near atmospheric pressure. Ions are entrained in a concentric flow of gas and travel through a high-transmission element into a RF/DC quadrupole, through a second high-transmission element, and then impact on an ion detector, such as a faraday plate; or through an aperture with subsequent identification by a mass spectrometer. Ions with stable trajectories pass through the RF/DC quadrupole while ions with unstable trajectories drift off-axis collide with the rods and are lost. Embodiments of this invention are devices and methods for focusing, separating and detecting gas-phase ions without the need for a vacuum chamber when coupled to atmospheric ionization sources.

    摘要翻译: 本发明涉及一种基本上在大气压或接近大气压的四极场的原理聚焦,分离和检测气相离子的装置和方法。 离子被夹带在同心圆的气体中,并通过第二高传导元件穿过高传输元件进入RF / DC四极杆,然后冲击到诸如法拉第板的离子检测器; 或通过孔径随后通过质谱仪进行识别。 具有稳定轨迹的离子通过RF / DC四极杆,而具有不稳定轨迹的离子偏离轴与棒碰撞并丢失。 本发明的实施例是用于在与大气电离源耦合时不需要真空室的情况下聚焦,分离和检测气相离子的装置和方法。

    Remote reagent chemical ionization source
    2.
    发明授权
    Remote reagent chemical ionization source 失效
    远程试剂化学电离源

    公开(公告)号:US06888132B1

    公开(公告)日:2005-05-03

    申请号:US10449344

    申请日:2003-05-30

    IPC分类号: H01J49/00

    CPC分类号: H01J49/145

    摘要: An improved ion source for collecting and focusing dispersed gas-phase ions from a reagent source at atmospheric or intermediate pressure, having a remote source of reagent ions separated from a low-field sample ionization region by a stratified array of elements, each element populated with a plurality of openings, wherein DC potentials are applied to each element necessary for transferring reagent ions from the remote source into the low-field sample ionization region where the reagent ions react with neutral and/or ionic sample forming ionic species. The resulting ionic species are then introduced into the vacuum system of a mass spectrometer or ion mobility spectrometer. Embodiments of this invention are methods and devices for improving sensitivity of mass spectrometry when gas and liquid chromatographic separation techniques are coupled to atmospheric and intermediate pressure photo-ionization, chemical ionization, and thermospray ionization sources.

    摘要翻译: 一种改进的离子源,用于在大气压或中压下从试剂源收集和聚焦分散的气相离子,其具有通过分层的元素阵列与低场样品电离区域分离的试剂离子的远程源,每个元素填充有 多个开口,其中DC电位被施加到将试剂离子从远程源传输到低场样品电离区所需的每个元件,其中试剂离子与形成中性和/或离子样品的离子物质反应。 然后将所得的离子物质引入质谱仪或离子迁移谱仪的真空系统中。 本发明的实施例是当气体和液相色谱分离技术与大气和中压光电离,化学电离和热喷射电离源耦合时提高质谱灵敏度的方法和装置。

    Remote reagent chemical ionization source
    3.
    发明授权
    Remote reagent chemical ionization source 失效
    远程试剂化学电离源

    公开(公告)号:US07095019B1

    公开(公告)日:2006-08-22

    申请号:US11120363

    申请日:2005-05-02

    IPC分类号: H01J49/00

    摘要: An improved ion source and portable analyzer for collecting and focusing dispersed gas-phase ions from a reagent source at atmospheric or intermediate pressure, having a remote source of reagent ions generated by direct or alternating currents, separated from a low-field sample ionization region by a stratified array of elements, each element populated with a plurality of openings, wherein DC potentials are applied to each element necessary for transferring reagent ions from the remote source into the low-field sample ionization region where the reagent ions react with neutral and/or ionic sample forming ionic species. The resulting ionic species are then introduced into the vacuum system of a mass spectrometer or ion mobility spectrometer. Embodiments of this invention are methods and devices for improving sensitivity of mass spectrometry when gas and liquid chromatographic separation techniques or probes containing samples are coupled to atmospheric and intermediate pressure photo-ionization, chemical ionization, and thermospray ionization sources.

    摘要翻译: 一种改进的离子源和便携式分析仪,用于在大气压或中压下从试剂源收集和聚焦分散的气相离子,具有通过直接或交流产生的远程离子源,由低场样品电离区分离, 元件的分层阵列,每个元件填充有多个开口,其中DC电势被施加到将试剂离子从远程源转移到低场样品电离区域中所需的每个元件,其中试剂离子与中性和/或 离子样品形成离子物种。 然后将所得的离子物质引入质谱仪或离子迁移谱仪的真空系统中。 本发明的实施例是当气体和液相色谱分离技术或含有样品的探针与大气压和中压光电离,化学电离和热喷射电离源耦合时提高质谱灵敏度的方法和装置。

    Apparatus and method for focusing ions and charged particles at atmospheric pressure
    4.
    发明授权
    Apparatus and method for focusing ions and charged particles at atmospheric pressure 失效
    在大气压力下聚焦离子和带电粒子的装置和方法

    公开(公告)号:US06744041B2

    公开(公告)日:2004-06-01

    申请号:US09877167

    申请日:2001-06-08

    IPC分类号: B01D5944

    CPC分类号: H01J49/067

    摘要: Improvements have been made for collection and focusing of ions generated from atmospheric pressure sources such as electrospray, atmospheric pressure chemical ionization, inductively coupled plasma, discharge, photoionization and atmospheric pressure matrix assisted laser desorption ionization. A high transmission electro-optical surface is placed between the source regions and the focusing regions to optimize the field geometries and strengths in each respective region. Compression ratios of greater than 5000 are capable of transferring virtually all ions from large volume dispersive ion regions into ion beam cross-sections of less than 1 mm. Embodiments of this invention are methods and devices for improving sensitivity of mass spectrometry when coupled to atmospheric pressure ionization sources.

    摘要翻译: 已经对电喷雾,大气压化学电离,电感耦合等离子体,放电,光电离和大气压力矩阵辅助激光解吸电离等大气压源产生的离子的收集和聚焦进行了改进。 将高透射电光表面放置在源区域和聚焦区域之间,以优化每个相应区域中的场几何形状和强度。 大于5000的压缩比能够将几乎所有的离子从大体积分散离子区转移到小于1mm的离子束横截面。 本发明的实施方案是当与大气压电离源耦合时提高质谱灵敏度的方法和装置。

    Remote reagent chemical ionization source
    5.
    发明授权
    Remote reagent chemical ionization source 失效
    远程试剂化学电离源

    公开(公告)号:US07253406B1

    公开(公告)日:2007-08-07

    申请号:US11491634

    申请日:2006-07-24

    IPC分类号: H01J49/00

    CPC分类号: H01J49/145

    摘要: An improved ion source for collecting and focusing dispersed gas-phase ions from a reagent source at sub-atmospheric or intermediate pressure, having a remote source of reagent ions separated from a low-field sample ionization region by a barrier, comprised of alternating laminates of metal and insulator, populated with a plurality of openings, wherein DC potentials are applied to each metal laminate necessary for transferring reagent ions from the remote source into the low-field sample ionization region where the reagent ions react with neutral and/or ionic sample forming ionic species. The resulting ionic species are then introduced into the vacuum system of a mass spectrometer or ion mobility spectrometer. Embodiments of this invention are methods and devices for improving sensitivity of mass spectrometry when gas and liquid chromatographic separation techniques are coupled to sub-atmospheric and intermediate pressure photo-ionization, chemical ionization, and thermal-pneumatic ionization sources.

    摘要翻译: 一种改进的离子源,用于在亚大气压或中压下从试剂源收集和聚焦分散的气相离子,其具有通过阻挡层从低场样品离子化区域分离出的远程试剂离子源,其包括交替层叠的 金属和绝缘体,其中填充有多个开口,其中DC电位被施加到将试剂离子从远程源传输到低场样品电离区域所需的每个金属层压体上,其中试剂离子与中性和/或离子样品形成 离子物种。 然后将所得的离子物质引入质谱仪或离子迁移谱仪的真空系统中。 本发明的实施例是当气体和液相色谱分离技术与亚大气压和中压光电离,化学电离和热 - 气动电离源耦合时提高质谱的灵敏度的方法和装置。

    Laminated lens for focusing ions from atmospheric pressure
    6.
    发明授权
    Laminated lens for focusing ions from atmospheric pressure 失效
    用于聚焦大气压离子的层压透镜

    公开(公告)号:US06818889B1

    公开(公告)日:2004-11-16

    申请号:US10449147

    申请日:2003-05-31

    IPC分类号: B01D5944

    CPC分类号: H01J49/10 H01J49/04

    摘要: A thin laminated high transmission electro-optical lens populated with a plurality of apertures in communication with its laminates used to improve the collection, focusing, and selection of ions generated from atmospheric pressure sources, such as electrospray, atmospheric pressure chemical ionization, inductively coupled plasma, discharge, photoionization and atmospheric pressure matrix assisted laser desorption ionization. The laminated lens is made of alternating layers of electrically insulating and metal laminates. The geometry of the lens may be planar or shaped into various curve shapes, any of which act to optimize the direct current (DC) electric field geometries and strengths across the lens for transferring virtually all the ions from the ion source into an ion-focusing region. Embodiments of this invention are methods and devices for improving sensitivity of mass spectrometry when coupled to atmospheric pressure ionization sources.

    摘要翻译: 薄层叠高透射电光透镜,填充有与其层叠体连通的多个孔,用于改善从大气压源(例如电喷雾,大气压化学电离,电感耦合等离子体)产生的离子的收集,聚焦和选择 ,放电,光电离和大气压矩阵辅助激光解吸电离。 层压透镜由电绝缘和金属层压体的交替层制成。 透镜的几何形状可以是平面的或成形为各种曲线形状,其中任何一个都用于优化跨透镜的直流(DC)电场几何形状和强度,用于将几乎所有离子从离子源转移到离子聚焦 地区。 本发明的实施方案是当与大气压电离源耦合时提高质谱灵敏度的方法和装置。

    Efficient direct current collision and reaction cell
    7.
    发明授权
    Efficient direct current collision and reaction cell 失效
    高效的直流碰撞和反应池

    公开(公告)号:US06781117B1

    公开(公告)日:2004-08-24

    申请号:US10447645

    申请日:2003-05-29

    IPC分类号: B01D5944

    摘要: An improved collison or reaction cell for collecting and focusing gas-phase ions in a mixture from an ion source or a mass analyzer into a gas-filled collision cell, inducing fragmentation or reaction of the ions by interaction with neutral or ionic gas-phase species, passing the resultant ionic products into another mass analyzer, determining the mass spectrum of the collision fragment ions to confirm the identity of the components in a mixture. The collision cell simultaneously provides collision gas confinements, precursor and product ion confinement, variability of collision energy, and variability of the DC drift field in the collision cell. Embodiments of this invention are methods and devices for improving the information content of chemical ionic species when coupled in tandem with mass analyzers.

    摘要翻译: 一种用于将离子源或质量分析器的混合物中的气相离子收集并聚焦到气体填充的碰撞池中的改进的聚光或反应池,通过与中性或离子气相物质的相互作用诱导离子的碎裂或反应 ,将得到的离子产物转移到另一个质量分析器中,确定碰撞碎片离子的质谱,以确认混合物中组分的同一性。 碰撞池同时提供碰撞气体约束,前体和产物离子限制,碰撞能量的变异性和碰撞池中的DC漂移场的变异性。 本发明的实施例是用于在与质量分析器串联时改善化学离子物质的信息含量的方法和装置。