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    Contrast Agent
    3.
    发明申请
    Contrast Agent 审中-公开
    对比剂

    公开(公告)号：US20080152593A1

    公开(公告)日：2008-06-26

    申请号：US11793655

    申请日：2005-12-21

    申请人： Sumio Iijima ,  Jin Miyawaki ,  Masako Yudasaka ,  Eiichi Nakamura ,  Hiroyuki Isobe ,  Hideki Yorimitsu ,  Hideto Imai

    发明人： Sumio Iijima ,  Jin Miyawaki ,  Masako Yudasaka ,  Eiichi Nakamura ,  Hiroyuki Isobe ,  Hideki Yorimitsu ,  Hideto Imai

    IPC分类号： A61K49/06

    CPC分类号： A61K49/189 ,  A61B5/055 ,  B82Y5/00 ,  G01R33/281

    摘要： A contrast agent characterized in that each of carbon nanohorns forming a carbon nanohorn aggregate has an opening at the side wall or tip, wherein a metal M (at least one metal selected from among paramagnetic metals, ferromagnetic metals, and superparamagnetic metals) or a compound of the metal M is incorporated in or dispersed on each of the carbon nanohorns. A contrast agent characterized in that it contains a Gd oxide. There is provided a contrast agent, which can be mass-produced easily, and satisfies the requirement of low toxicity and enables microscopic diagnoses when used for MRI. A contrast agent characterized in that is contains a carbon nanohorn aggregate.

    摘要翻译： 一种造影剂，其特征在于，形成碳纳米角骨料的每个碳纳米角具有在侧壁或尖端处的开口，其中金属M（选自顺磁金属，铁磁性金属和超顺磁金属中的至少一种金属）或化合物 的金属M掺入或分散在每个碳纳米角上。 一种造影剂，其特征在于其含有Gd氧化物。 提供了可以容易地批量生产的造影剂，并且满足低毒性的要求并且在用于MRI时能够进行显微诊断。 其特征在于含有碳纳米角骨料的造影剂。

    CARBON NANOHORN MRI CONTRAST AGENTS
    4.
    发明申请
    CARBON NANOHORN MRI CONTRAST AGENTS 审中-公开
    碳纳米星MRI对比剂

    公开(公告)号：US20120058053A1

    公开(公告)日：2012-03-08

    申请号：US13295621

    申请日：2011-11-14

    申请人： Sumio Iijima ,  Jin Miyawaki ,  Masako Yudasaka ,  Eiichi Nakamura ,  Hiroyuki Isobe ,  Hideki Yorimitsu ,  Hideto Imai

    发明人： Sumio Iijima ,  Jin Miyawaki ,  Masako Yudasaka ,  Eiichi Nakamura ,  Hiroyuki Isobe ,  Hideki Yorimitsu ,  Hideto Imai

    IPC分类号： A61B5/055 ,  B82Y5/00

    CPC分类号： A61K49/189 ,  A61B5/055 ,  B82Y5/00 ,  G01R33/281

    摘要： A contrast agent characterized in that each of carbon nanohorns forming a carbon nanohorn aggregate has an opening at the side wall or tip, wherein a metal M (at least one metal selected from among paramagnetic metals, ferromagnetic metals, and superparamagnetic metals) or a compound of the metal M is incorporated in or dispersed on each of the carbon nanohorns. A contrast agent characterized in that it contains a Gd oxide. There is provided a contrast agent, which can be mass-produced easily, and satisfies the requirement of low toxicity and enables microscopic diagnoses when used for MRI. A contrast agent characterized in that is contains a carbon nanohorn aggregate.

    摘要翻译： 一种造影剂，其特征在于，形成碳纳米角骨料的每个碳纳米角具有在侧壁或尖端处的开口，其中金属M（选自顺磁金属，铁磁性金属和超顺磁金属中的至少一种金属）或化合物 的金属M掺入或分散在每个碳纳米角上。 一种造影剂，其特征在于其含有Gd氧化物。 提供了可以容易地批量生产的造影剂，并且满足低毒性的要求并且在用于MRI时能够进行显微诊断。 其特征在于含有碳纳米角骨料的造影剂。

    Substance-containing carbon nanohorn composite having polyamine plug and process for producing the same
    5.
    发明授权
    Substance-containing carbon nanohorn composite having polyamine plug and process for producing the same 有权
    含有多胺栓塞的含物质碳纳米复合材料及其制造方法

    公开(公告)号：US08084505B2

    公开(公告)日：2011-12-27

    申请号：US12307473

    申请日：2007-07-03

    申请人： Ryota Yuge ,  Hideki Yorimitsu ,  Masako Yudasaka ,  Sumio Iijima

    发明人： Ryota Yuge ,  Hideki Yorimitsu ,  Masako Yudasaka ,  Sumio Iijima

    IPC分类号： A61K9/14 ,  A61K31/13 ,  A61K31/16 ,  A01N33/00 ,  A01N33/02

    CPC分类号： B82Y30/00 ,  B82Y40/00 ,  C01B32/18 ,  Y10S977/734 ,  Y10S977/736 ,  Y10S977/74 ,  Y10S977/744 ,  Y10S977/748 ,  Y10S977/75

    摘要： The present invention provides: a carbon nanohorn composite including a carbon nanohorn, a substance encapsulated in the carbon nanohorn, and a polyamine adsorbed by chemical reaction firmly to a surface functional group present on the opening part on the surface of the carbon nanohorn, wherein the release amount and release rate of the encapsulated substance can be controlled using the difference in size, substituent or three-dimensional structure of the polyamine, which is used as a plug; a method of controlling the release of the encapsulated substance; and a process for producing the carbon nanohorn composite. The release amount and release rate of the substance encapsulated in the carbon nanohorn composite is controlled by selecting a polyamine molecule, which plugs the opening part formed in the carbon nanohorn by oxidation, by its size, substituent or three-dimensional structure.

    摘要翻译： 本发明提供了一种碳纳米角复合材料，其包含碳纳米角，包封在碳纳米角中的物质，以及通过化学反应吸附的多胺与存在于碳纳米角表面上的开口部分上的表面官能团，其中， 可以使用用作塞子的多胺的尺寸，取代基或三维结构的差异来控制包封物质的释放量和释放速率; 控制包封物质释放的方法; 以及生产碳纳米复合材料的方法。 通过选择通过其尺寸，取代基或三维结构通过氧化将形成在碳纳米角中的开口部分堵塞的多胺分子来控制包封在碳纳米角复合材料中的物质的释放量和释放速率。

    SUBSTANCE-CONTAINING CARBON NANOHORN COMPOSITE HAVING POLYAMINE PLUG AND PROCESS FOR PRODUCING THE SAME
    6.
    发明申请
    SUBSTANCE-CONTAINING CARBON NANOHORN COMPOSITE HAVING POLYAMINE PLUG AND PROCESS FOR PRODUCING THE SAME 有权
    具有聚氨酯弹性体的含碳纳米复合材料及其制造方法

    公开(公告)号：US20090208567A1

    公开(公告)日：2009-08-20

    申请号：US12307473

    申请日：2007-07-03

    申请人： Ryota Yuge ,  Hideki Yorimitsu ,  Masako Yudasaka ,  Sumio Iijima

    发明人： Ryota Yuge ,  Hideki Yorimitsu ,  Masako Yudasaka ,  Sumio Iijima

    IPC分类号： A61K47/18 ,  A61K9/48

    CPC分类号： B82Y30/00 ,  B82Y40/00 ,  C01B32/18 ,  Y10S977/734 ,  Y10S977/736 ,  Y10S977/74 ,  Y10S977/744 ,  Y10S977/748 ,  Y10S977/75

    摘要： The present invention provides: a carbon nanohorn composite including a carbon nanohorn, a substance encapsulated in the carbon nanohorn, and a polyamine adsorbed by chemical reaction firmly to a surface functional group present on the opening part on the surface of the carbon nanohorn, wherein the release amount and release rate of the encapsulated substance can be controlled using the difference in size, substituent or three-dimensional structure of the polyamine, which is used as a plug; a method of controlling the release of the encapsulated substance; and a process for producing the carbon nanohorn composite. The release amount and release rate of the substance encapsulated in the carbon nanohorn composite is controlled by selecting a polyamine molecule, which plugs the opening part formed in the carbon nanohorn by oxidation, by its size, substituent or three-dimensional structure.

    摘要翻译： 本发明提供了一种碳纳米角复合材料，其包含碳纳米角，包封在碳纳米角中的物质，以及通过化学反应吸附的多胺与存在于碳纳米角表面上的开口部分上的表面官能团，其中， 可以使用用作塞子的多胺的尺寸，取代基或三维结构的差异来控制包封物质的释放量和释放速率; 控制包封物质释放的方法; 以及生产碳纳米复合材料的方法。 通过选择通过其尺寸，取代基或三维结构通过氧化将形成在碳纳米角中的开口部分堵塞的多胺分子来控制包封在碳纳米角复合材料中的物质的释放量和释放速率。