公开(公告)号：US06548543B1

公开(公告)日：2003-04-15

申请号：US09763244

申请日：2001-02-20

申请人： Eiji Kobayashi ,  Hiromu Ohnogi ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Katsushige Ikai ,  Ikunoshin Kato

发明人： Eiji Kobayashi ,  Hiromu Ohnogi ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Katsushige Ikai ,  Ikunoshin Kato

IPC分类号： A61K31215

CPC分类号： A61K31/215 ,  A61K31/22 ,  C07C69/013 ,  C07C2601/10 ,  Y02A50/411

摘要： Remedies or preventives for diseases with a need for immunoregulation, diseases with a need for inhibition of inflammation, diseases with a need for regulation of tumor necrosis factor production, diseases with a need for regulation of fungal growth, diseases with a need for regulation of cell adhesion or disease with a deed for induction of heat-shock protein, which contain as the active ingredient at least one compound selected from among cyclopentenone derivatives represented by general formula [I], optically active isomers and salts thereof, wherein R1 and R2 are the same or different and each represents hydrogen, an aliphatic group, an aromatic group or an aromatic aliphatic group.

摘要翻译： 需要免疫调节的疾病的治疗或预防措施，需要抑制炎症的疾病，需要调节肿瘤坏死因子产生的疾病，需要调节真菌生长的疾病，需要调节细胞的疾病 含有作为活性成分的至少一种选自通式[I]表示的环戊烯酮衍生物的化合物，其光学活性异构体和盐，其中R 1和R 2为 相同或不同，各自表示氢，脂族基，芳基或芳族脂族基。

公开(公告)号：US06177592B1

公开(公告)日：2001-01-23

申请号：US09341768

申请日：1999-07-16

申请人： Nobuto Koyama ,  Tatsuji Enoki ,  Katsushige Ikai ,  Hua-Kang Wu ,  Hiromu Ohnogi ,  Takanari Tominaga ,  Eiji Nishiyama ,  Michio Hagiya ,  Hiroaki Sagawa ,  Hideto Chono ,  Ikunoshin Kato

发明人： Nobuto Koyama ,  Tatsuji Enoki ,  Katsushige Ikai ,  Hua-Kang Wu ,  Hiromu Ohnogi ,  Takanari Tominaga ,  Eiji Nishiyama ,  Michio Hagiya ,  Hiroaki Sagawa ,  Hideto Chono ,  Ikunoshin Kato

IPC分类号： C07C6106

CPC分类号： C07C323/59 ,  A23K20/105 ,  A23L2/52 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/122 ,  C07C45/60 ,  C07C45/78 ,  C07C49/707 ,  C07C323/58 ,  C07C2601/08 ,  Y02A50/478 ,  A23V2200/224 ,  A23V2250/5026 ,  A23V2250/5024 ,  A23V2250/70 ,  A23V2250/204 ,  A23V2250/06 ,  A23V2250/21

摘要： A compound represented by the following formula [I] or an optically active substance or a salt thereof. (In the formula, a bond shown by a dotted line in the five-membered ring means that said five-membered ring may be any of a cyclopentene ring having a double bond and a cyclopentane ring where said bond is saturated and, in the case of a cyclopentene ring, X is OH, Y is ═O and Z is H while, in the case of a cyclopentane ring, X is ═O, Y is OH and Z is OH. R is a residue after removal of an SH group from the SH-containing compound.)

摘要翻译： 由下式[I]表示的化合物或光学活性物质或其盐（在该式中，五元环中虚线所示的键表示所述五元环可以是 具有双键的环戊烯环和所述键饱和的环戊烷环，在环戊烯环的情况下，X为OH，Y为= O且Z为H，而在环戊烷环的情况下，X为= O，Y是OH，Z是OH，R是从含SH的化合物除去SH基团后的残基。

公开(公告)号：US06482806B1

公开(公告)日：2002-11-19

申请号：US09125397

申请日：1998-08-18

申请人： Nobuto Koyama ,  Hiroaki Sagawa ,  Eiji Kobayashi ,  Tatsuji Enoki ,  Hua-Kang Wu ,  Eiji Nishiyama ,  Suzu Deguchi ,  Katsushige Ikai ,  Hiromu Ohnogi ,  Motoko Ueda ,  Akihiro Kondo ,  Ikunoshin Kato

发明人： Nobuto Koyama ,  Hiroaki Sagawa ,  Eiji Kobayashi ,  Tatsuji Enoki ,  Hua-Kang Wu ,  Eiji Nishiyama ,  Suzu Deguchi ,  Katsushige Ikai ,  Hiromu Ohnogi ,  Motoko Ueda ,  Akihiro Kondo ,  Ikunoshin Kato

IPC分类号： A61K31727

CPC分类号： C07H7/033 ,  A61K8/60 ,  A61Q11/00 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93

摘要： A product obtained by heating at least one substance selected from the following (a), (b) and (c). (a) uronic acid or uronic acid derivative; (b) a saccharide compound containing uronic acid or a saccharide compound containing uronic acid derivative; and (c) a substance containing a saccharide compound containing uronic acid or a substance containing a saccharide compound containing uronic acid derivative; and food, beverage or a pharmaceutical agent which is characterized in containing the above-mentioned heat-treated product.

摘要翻译： 通过加热选自以下（a），（b）和（c）中的至少一种物质获得的产物：（a）糖醛酸或糖醛酸衍生物;（b）含有糖醛酸或含有糖醛酸的糖类化合物的糖类化合物 酸衍生物; 和（c）含有糖醛酸的糖类化合物或含有糖醛酸衍生物的糖类化合物的物质的物质;以及含有上述热处理物的食品，饮料或药剂。

公开(公告)号：US20050202064A1

公开(公告)日：2005-09-15

申请号：US11114071

申请日：2005-04-26

申请人： Nobuto Koyama ,  Hiroaki Sagawa ,  Eiji Kobayashi ,  Tatsuji Enoki ,  Hua-Kang Wu ,  Eiji Nishiyama ,  Suzu Deguchi ,  Katsushige Ikai ,  Hiromu Ohnogi ,  Motoko Ueda ,  Akihiro Kondo ,  Ikunoshin Kato

发明人： Nobuto Koyama ,  Hiroaki Sagawa ,  Eiji Kobayashi ,  Tatsuji Enoki ,  Hua-Kang Wu ,  Eiji Nishiyama ,  Suzu Deguchi ,  Katsushige Ikai ,  Hiromu Ohnogi ,  Motoko Ueda ,  Akihiro Kondo ,  Ikunoshin Kato

IPC分类号： A23L3/3562 ,  A61K8/60 ,  A61K31/19 ,  A61K31/70 ,  A61K31/7012 ,  A61K31/715 ,  A61K31/727 ,  A61K31/728 ,  A61K31/732 ,  A61K31/734 ,  A61K31/737 ,  A61K35/00 ,  A61K35/12 ,  A61K35/74 ,  A61K36/00 ,  A61L2/16 ,  A61P35/00 ,  A61Q11/00 ,  C07H7/033 ,  C08B37/00

CPC分类号： C07H7/033 ,  A61K8/60 ,  A61Q11/00 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93

摘要： A product obtained by heating at least one substance selected from the following (a), (b) and (c). (a) uronic acid or uronic acid derivative; (b) a saccharide compound containing uronic acid or a saccharide compound containing uronic acid derivative; and (c) a substance containing a saccharide compound containing uronic acid or a substance containing a saccharide compound containing uronic acid derivative; and food, beverage or a pharmaceutical agent which is characterized in containing the above-mentioned heat-treated product.

摘要翻译： 通过加热至少一种选自以下（a），（b）和（c）的物质而得到的产物。 （a）糖醛酸或糖醛酸衍生物; （b）含有糖醛酸的糖类化合物或含有糖醛酸衍生物的糖类化合物; 和（c）含有糖醛酸的糖类化合物或含有糖醛酸衍生物的糖类化合物的物质的物质; 以及食品，饮料或药剂，其特征在于含有上述热处理产品。

公开(公告)号：US20090099101A1

公开(公告)日：2009-04-16

申请号：US12222492

申请日：2008-08-11

申请人： Tatsuji Enoki ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Takeshi Sakai ,  Fu-Gong Yu ,  Katsushige Ikai ,  Ikunoshin Kato

发明人： Tatsuji Enoki ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Takeshi Sakai ,  Fu-Gong Yu ,  Katsushige Ikai ,  Ikunoshin Kato

IPC分类号： A61K31/70 ,  A61K31/335

CPC分类号： A01N43/04 ,  A23L3/3472 ,  A23L3/3544 ,  A23L3/3562 ,  A23L33/105 ,  A61K31/341 ,  A61K31/7048

摘要： Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose represented by formula (1): foods, drinks, cosmetics, etc. containing as the active ingredient at least one member selected from the group consisting of the above-mentioned compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. This compound also shows, for example, an apoptosis-inducing activity, a carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes it useful also as the active ingredient of antioxidants and preservatives.

摘要翻译： 用于治疗，改善或预防对由式（1）表示的3,6-脱水吡喃半乳糖敏感的疾病的药物组合物：含有作为活性成分的至少一种选自上述组分的组分的食品，饮料，化妆品等， 所述化合物，其醛，其水合物和2-O-甲基化衍生物以及含有上述化合物的可溶性糖化合物。 该化合物还显示例如细胞凋亡诱导活性，制癌活性和对活性氧，脂质过氧化物自由基和NO的产生的抑制活性，这使得它也可用作抗氧化剂和防腐剂的活性成分。

公开(公告)号：US06911432B2

公开(公告)日：2005-06-28

申请号：US10228195

申请日：2002-08-27

申请人： Tatsuji Enoki ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Takeshi Sakai ,  Fu-Gong Yu ,  Katsushige Ikai ,  Ikunoshin Kato

发明人： Tatsuji Enoki ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Takeshi Sakai ,  Fu-Gong Yu ,  Katsushige Ikai ,  Ikunoshin Kato

IPC分类号： A23L1/30 ,  A23L3/3472 ,  A23L3/3544 ,  A23L3/3562 ,  A61K31/341 ,  C07G99/00 ,  A01N43/04

CPC分类号： A01N43/04 ,  A23L3/3472 ,  A23L3/3544 ,  A23L3/3562 ,  A23L33/105 ,  A61K31/341 ,  A61K31/7048

摘要： Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose are represented by formula (I): These compositions include foods, drinks, cosmetics, etc. containing as the active ingredient at least one such compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. These compounds show an apoptosis-inducing activity, carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes them useful also as the active ingredient of antioxidants and preservatives.

摘要翻译： 用于治疗，改善或预防对3,6-脱水吡喃半乳糖敏感的疾病的药物组合物由式（I）表示：这些组合物包括含有至少一种这样的化合物，其醛， 其水合物和2-O-甲基化衍生物和含有上述化合物的可溶性糖化合物。 这些化合物对活性氧，脂质过氧化物自由基和NO的生成表现出细胞凋亡诱导活性，制癌活性和抑制活性，这使得它们也可用作抗氧化剂和防腐剂的活性成分。

公开(公告)号：US20050119191A1

公开(公告)日：2005-06-02

申请号：US11034243

申请日：2005-01-13

申请人： Tatsui Enoki ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Takeshi Sakai ,  Fu-Gong Yu ,  Katsushige Ikai ,  Ikunoshin Kato

发明人： Tatsui Enoki ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Takeshi Sakai ,  Fu-Gong Yu ,  Katsushige Ikai ,  Ikunoshin Kato

IPC分类号： A23L1/30 ,  A23L3/3472 ,  A23L3/3544 ,  A23L3/3562 ,  A61K31/341 ,  C07G99/00 ,  A61K31/70 ,  A61K31/335

CPC分类号： A01N43/04 ,  A23L3/3472 ,  A23L3/3544 ,  A23L3/3562 ,  A23L33/105 ,  A61K31/341 ,  A61K31/7048

摘要： Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose represented by formula (1): foods, drinks, cosmetics, etc. containing as the active ingredient at least one member selected from the group consisting of the above-mentioned compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. This compound also shows, for example, an apoptosis-inducing activity, a carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes it useful also as the active ingredient of antioxidants and preservatives.

摘要翻译： 用于治疗，改善或预防对由式（1）表示的3,6-脱水吡喃半乳糖敏感的疾病的药物组合物：含有作为活性成分的至少一种选自上述组分的组分的食品，饮料，化妆品等， 所述化合物，其醛，其水合物和2-O-甲基化衍生物以及含有上述化合物的可溶性糖化合物。 该化合物还显示例如细胞凋亡诱导活性，制癌活性和对活性氧，脂质过氧化物自由基和NO的产生的抑制活性，这使得它也可用作抗氧化剂和防腐剂的活性成分。

公开(公告)号：US06475990B1

公开(公告)日：2002-11-05

申请号：US09554235

申请日：2000-05-11

申请人： Tatsuji Enoki ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Takeshi Sakai ,  Fu-Gong Yu ,  Katsushige Ikai ,  Ikunoshin Kato

发明人： Tatsuji Enoki ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Takeshi Sakai ,  Fu-Gong Yu ,  Katsushige Ikai ,  Ikunoshin Kato

IPC分类号： A01N4304

CPC分类号： A01N43/04 ,  A23L3/3472 ,  A23L3/3544 ,  A23L3/3562 ,  A23L33/105 ,  A61K31/341 ,  A61K31/7048

摘要： Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose represented by formula (1): foods, drinks, cosmetics, etc. containing as the active ingredient at least one member selected from the group consisting of the above-mentioned compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. This compound also shows, for example, an apoptosis-inducing activity, a carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes it useful also as the active ingredient of antioxidants and preservatives.

摘要翻译： 用于治疗，改善或预防对由式（1）表示的3,6-脱水吡喃半乳糖敏感的疾病的药物组合物：含有作为活性成分的至少一种选自上述组分的组分的食品，饮料，化妆品等， 所述化合物，其醛，其水合物和2-O-甲基化衍生物以及含有上述化合物的可溶性糖化合物。 该化合物还显示例如细胞凋亡诱导活性，制癌活性和对活性氧，脂质过氧化物自由基和NO的产生的抑制活性，这使得它也可用作抗氧化剂和防腐剂的活性成分。

公开(公告)号：US07417031B2

公开(公告)日：2008-08-26

申请号：US11034243

申请日：2005-01-13

申请人： Tatsui Enoki ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Takeshi Sakai ,  Fu-Gong Yu ,  Katsushige Ikai ,  Ikunoshin Kato

发明人： Tatsui Enoki ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Takeshi Sakai ,  Fu-Gong Yu ,  Katsushige Ikai ,  Ikunoshin Kato

IPC分类号： A01N43/04 ,  A61K31/715 ,  C07G3/00 ,  C07G11/00 ,  C07G17/00 ,  C07H15/00 ,  C07H17/00 ,  C08B37/00

CPC分类号： A01N43/04 ,  A23L3/3472 ,  A23L3/3544 ,  A23L3/3562 ,  A23L33/105 ,  A61K31/341 ,  A61K31/7048

摘要： Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose represented by formula (1): foods, drinks, cosmetics, etc. containing as the active ingredient at least one member selected from the group consisting of the above-mentioned compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. This compound also shows, for example, an apoptosis-inducing activity, a carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes it useful also as the active ingredient of antioxidants and preservatives.

摘要翻译： 用于治疗，改善或预防对由式（1）表示的3,6-脱水吡喃半乳糖敏感的疾病的药物组合物：含有作为活性成分的至少一种选自上述组分的组分的食品，饮料，化妆品等， 所述化合物，其醛，其水合物和2-O-甲基化衍生物以及含有上述化合物的可溶性糖化合物。 该化合物还显示例如细胞凋亡诱导活性，制癌活性和对活性氧，脂质过氧化物自由基和NO的产生的抑制活性，这使得它也可用作抗氧化剂和防腐剂的活性成分。

公开(公告)号：US06380262B1

公开(公告)日：2002-04-30

申请号：US09762265

申请日：2001-02-06

申请人： Eiji Kobayashi ,  Hiromu Ohnogi ,  Nobuto Koyama ,  Katsushige Ikai ,  Hiroaki Sagawa ,  Ikunoshin Kato

发明人： Eiji Kobayashi ,  Hiromu Ohnogi ,  Nobuto Koyama ,  Katsushige Ikai ,  Hiroaki Sagawa ,  Ikunoshin Kato

IPC分类号： A61K3112

CPC分类号： C07K5/0215 ,  A61K38/00

摘要： 5-Membered ring compounds represented by general formula (I), optically active isomers thereof or salts of the same. These compounds have physiological activities including a carcinostatic effect. In said formula the bond shown by the dotted line in the 5-membered ring represents that this 5-membered ring may be either a cyclopentene ring having a double bond or a saturated cyclopentane ring, and when the 5-membered ring is a cyclopentene ring, X is OR1, Y is ═O and Z is H, and when it is a cyclopentane ring, X is ═O, Y is OR2 and Z is OR3, (wherein R1 is R4 or —(CO)—R5; R2 is H, —R6 or —(CO)—R7; and R3 is H, R8 or (CO)—R9 (wherein R4, R5, R6, R7, R8 and R9 are the same or different and each represents an aliphatic, aromatic or aliphatic aromatic group, and R5, R7 and R9 may be each H), provided that the case where R2═R3═H is excluded); and W represents a residue obtained by eliminating SH from an SH-containing compound.

摘要翻译： 由通式（I）表示的5-元环化合物，其旋光异构体或其盐。 这些化合物具有包括致癌作用的生理活性。 在所述式中，五元环中虚线所示的键表示该5元环可以是具有双键或饱和环戊烷环的环戊烯环，当5元环为环戊烯环时 X为OR 1，Y为= O且Z为H，当为环戊烷环时，X为= O，Y为OR 2，Z为OR 3，（其中R1为R4或 - （CO）-R5; R2为 H，-R6或 - （CO）-R7; R3为H，R8或（CO）-R9（其中R4，R5，R6，R7，R8和R9相同或不同，各自表示脂族，芳族或 脂族芳族基团，R 5，R 7和R 9可以各自为H），条件是排除R2 = R3 = H的情况）; W表示通过从含SH化合物中除去SH而得到的残基。