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    5-membered ring compounds
    7.
    发明授权
    5-membered ring compounds 失效
    5元环化合物

    公开(公告)号：US06380262B1

    公开(公告)日：2002-04-30

    申请号：US09762265

    申请日：2001-02-06

    申请人： Eiji Kobayashi ,  Hiromu Ohnogi ,  Nobuto Koyama ,  Katsushige Ikai ,  Hiroaki Sagawa ,  Ikunoshin Kato

    发明人： Eiji Kobayashi ,  Hiromu Ohnogi ,  Nobuto Koyama ,  Katsushige Ikai ,  Hiroaki Sagawa ,  Ikunoshin Kato

    IPC分类号： A61K3112

    CPC分类号： C07K5/0215 ,  A61K38/00

    摘要： 5-Membered ring compounds represented by general formula (I), optically active isomers thereof or salts of the same. These compounds have physiological activities including a carcinostatic effect. In said formula the bond shown by the dotted line in the 5-membered ring represents that this 5-membered ring may be either a cyclopentene ring having a double bond or a saturated cyclopentane ring, and when the 5-membered ring is a cyclopentene ring, X is OR1, Y is ═O and Z is H, and when it is a cyclopentane ring, X is ═O, Y is OR2 and Z is OR3, (wherein R1 is R4 or —(CO)—R5; R2 is H, —R6 or —(CO)—R7; and R3 is H, R8 or (CO)—R9 (wherein R4, R5, R6, R7, R8 and R9 are the same or different and each represents an aliphatic, aromatic or aliphatic aromatic group, and R5, R7 and R9 may be each H), provided that the case where R2═R3═H is excluded); and W represents a residue obtained by eliminating SH from an SH-containing compound.

    摘要翻译： 由通式（I）表示的5-元环化合物，其旋光异构体或其盐。 这些化合物具有包括致癌作用的生理活性。 在所述式中，五元环中虚线所示的键表示该5元环可以是具有双键或饱和环戊烷环的环戊烯环，当5元环为环戊烯环时 X为OR 1，Y为= O且Z为H，当为环戊烷环时，X为= O，Y为OR 2，Z为OR 3，（其中R1为R4或 - （CO）-R5; R2为 H，-R6或 - （CO）-R7; R3为H，R8或（CO）-R9（其中R4，R5，R6，R7，R8和R9相同或不同，各自表示脂族，芳族或 脂族芳族基团，R 5，R 7和R 9可以各自为H），条件是排除R2 = R3 = H的情况）; W表示通过从含SH化合物中除去SH而得到的残基。