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    Percutaneous absorption promoter, a tape plaster and a method of promoting percutaneous absorpton
    1.
    发明授权
    Percutaneous absorption promoter, a tape plaster and a method of promoting percutaneous absorpton 失效
    经皮吸收促进剂，胶带膏和促进经皮吸收剂的方法

    公开(公告)号：US5413794A

    公开(公告)日：1995-05-09

    申请号：US937783

    申请日：1992-09-01

    申请人： Eiji Suzuki ,  Hideaki Okabe ,  Takanori Saito

    发明人： Eiji Suzuki ,  Hideaki Okabe ,  Takanori Saito

    IPC分类号： A61K9/70 ,  A61K47/18 ,  C07C229/56 ,  C07C233/54 ,  A61F13/00

    CPC分类号： A61K9/7061 ,  A61K47/18 ,  A61K47/183 ,  A61K9/0014 ,  Y10S514/946 ,  Y10S514/947

    摘要： A percutaneous absorption promoter comprises a derivative of amino acid in which the amino group has or does not have an acyl substituent or a hydrocarbon substituent, the carboxylic group has a hydrocarbon substituent and the part between the amino group and the carboxylic group has a specified structure. A tape plaster comprises the percutaneous absorption promoter described above. The method utilizes the the percutaneous absorption promoter described above. The percutaneous promoter of the invention has excellent ability of promoting the percutaneous absorption of pharmacologically active substances and excellent safety simultaneously, capable of delivering the desired pharmacologically active substances rapidly to the location of treatment or to all parts of the body through the circulating system and effective for curing various kinds of disease. The tape plaster comprising it and the method of promoting percutaneous absorption by utilizing it have the same advantages.

    摘要翻译： 经皮吸收促进剂包括其中氨基具有或不具有酰基取代基或烃取代基的氨基酸衍生物，羧基具有烃取代基，氨基和羧基之间的部分具有特定的结构 。 胶带包含上述经皮吸收促进剂。 该方法利用上述经皮吸收促进剂。 本发明的经皮促进剂具有优异的促进药理活性物质的经皮吸收和同时具有优异安全性的能力，能够通过循环系统快速将期望的药理活性物质快速递送至身体的所有部位， 用于治疗各种疾病。 包含它的胶带膏和利用它促进经皮吸收的方法具有相同的优点。

    Percutaneous absorption promoter, a tape plaster and a method of promoting percutaneous absorption
    2.
    再颁专利
    Percutaneous absorption promoter, a tape plaster and a method of promoting percutaneous absorption 失效
    经皮吸收促进剂，胶带膏和促进经皮吸收的方法

    公开(公告)号：USRE36138E

    公开(公告)日：1999-03-09

    申请号：US854136

    申请日：1997-05-08

    申请人： Eiji Suzuki ,  Hideaki Okabe ,  Takanori Saito

    发明人： Eiji Suzuki ,  Hideaki Okabe ,  Takanori Saito

    IPC分类号： A61K9/70 ,  A61K47/18 ,  C07C229/56 ,  C07C233/54 ,  A61F13/00

    CPC分类号： A61K9/7061 ,  A61K47/18 ,  A61K47/183 ,  A61K9/0014 ,  Y10S514/946 ,  Y10S514/947

    摘要： A percutaneous absorption promoter comprises a derivative of amino acid in which the amino group has or does not have an acyl substituent or a hydrocarbon substituent, the carboxylic group has a hydrocarbon substituent and the part between the amino group and the carboxylic group has a specified structure. A tape plaster comprises the percutaneous absorption promoter described above. The method utilizes the the percutaneous absorption promoter described above. The percutaneous promoter of the invention has excellent ability of promoting the percutaneous absorption of pharmacologically active substances and excellent safety simultaneously, capable of delivering the desired pharmacologically active substances rapidly to the location of treatment or to all parts of the body through the circulating system and effective for curing various kinds of disease. The tape plaster comprising it and the method of promoting percutaneous absorption by utilizing it have the same advantages.

    摘要翻译： 经皮吸收促进剂包括其中氨基具有或不具有酰基取代基或烃取代基的氨基酸衍生物，羧基具有烃取代基，氨基和羧基之间的部分具有特定的结构 。 胶带包含上述经皮吸收促进剂。 该方法利用上述经皮吸收促进剂。 本发明的经皮促进剂具有优异的促进药理活性物质的经皮吸收和同时具有优异安全性的能力，能够通过循环系统快速将期望的药理活性物质快速递送至身体的所有部位， 用于治疗各种疾病。 包含它的胶带膏和利用它促进经皮吸收的方法具有相同的优点。

    Gel pharmaceutical formulation for local anesthesia
    3.
    发明授权
    Gel pharmaceutical formulation for local anesthesia 失效
    凝胶药物制剂局部麻醉

    公开(公告)号：US5589192A

    公开(公告)日：1996-12-31

    申请号：US353322

    申请日：1994-12-05

    申请人： Hideaki Okabe ,  Eiji Suzuki ,  Masao Kogure ,  Takanori Saito

    发明人： Hideaki Okabe ,  Eiji Suzuki ,  Masao Kogure ,  Takanori Saito

    IPC分类号： A61K9/70 ,  A61K31/165 ,  A61K31/167 ,  A61K31/245 ,  A61K45/00 ,  A61K47/32 ,  A61P23/02 ,  A61P25/02 ,  A61L15/00

    CPC分类号： A61K9/7061 ,  A61K31/245 ,  Y10S514/816 ,  Y10S514/818 ,  Y10S514/944 ,  Y10S514/946

    摘要： An article of manufacture in the form of a gel pharmaceutical formulation for local anesthesia is prepared by a process comprising: coating a supporting substrate, which preferably is porous, e.g., a non-woven fabric, and has an impervious backing sheet, with a matrix of a copolymer of alkyl (meth)acrylates and (meth)acrylic acid and a local anesthetic whereby the matrix penetrates the substrate, crosslinking the copolymer in the matrix to form a polymer/drug matrix, and coating the surface of the matrix with an aqueous fluid, thereby converting the matrix into a gel and preferably covering the gel matrix with an impervious protective sheet. The product has excellent percutaneous absorption, provides local anesthesia easily just by attaching the formulation to the skin, enables elimination of various kinds of pain, such as the pain at the time of hypodermic injection, can be removed easily from the skin, and causes no soiling of fingers, hands or cloths.

    摘要翻译： 用于局部麻醉的凝胶药物制剂形式的制品是通过以下方法制备的，该方法包括：将优选为多孔的支撑基底（例如无纺织物）涂覆并具有不透水的背衬片， 的（甲基）丙烯酸烷基酯和（甲基）丙烯酸烷基酯和局部麻醉剂的共聚物，由此基质渗透底物，使基质中的共聚物交联以形成聚合物/药物基质，并用水性 从而将基质转化成凝胶，并且优选用不透水的保护片覆盖凝胶基质。 该产品具有优异的经皮吸收，通过将配方附着到皮肤上即可轻松提供局部麻醉，能够消除各种疼痛，如皮下注射时的疼痛，可以容易地从皮肤上清除，不会导致 弄脏手指，手或布。

    Transdermal therapeutic formulation and a method of administration thereof
    4.
    发明授权
    Transdermal therapeutic formulation and a method of administration thereof 失效
    透皮治疗剂型及其施用方法

    公开(公告)号：US5744162A

    公开(公告)日：1998-04-28

    申请号：US929044

    申请日：1992-08-13

    申请人： Hideaki Okabe ,  Ichiro Tsuchida ,  Takanori Saito

    发明人： Hideaki Okabe ,  Ichiro Tsuchida ,  Takanori Saito

    IPC分类号： A61K9/70 ,  A61K47/32 ,  A61K9/14

    CPC分类号： A61K9/7061 ,  A61K47/32

    摘要： A transdermal therapeutic formulation is made of a composition comprising a polymer and ingredients mixed with the polymer which are a pharmacologically active substance, an alcohol, a percutaneous absorption promoter utilized according to necessity and water utilized according to necessity. The polymer comprises lipophilic monomer units and hydrophilic monomer units in a specific ratio. The alcohol, the percutaneous absorption promoter and water are mixed with the polymer in specific amounts. The transdermal therapeutic formulation has excellent percutaneous absorption, has many kinds of applicable pharmacologically active substances, shows good stability of percutaneous absorption with time because of absence of crystallization of the pharmacologically active substance, has good adhesive strength and thus favorably utilized as transdermal therapeutic plaster.

    摘要翻译： 透皮治疗制剂由包含聚合物和与聚合物混合的成分组成的组合物制成，所述组合物是药理活性物质，醇，根据需要使用的经皮吸收促进剂和根据需要使用的水。 聚合物包含亲脂性单体单元和具有特定比例的亲水性单体单元。 将醇，经皮吸收促进剂和水与特定量的聚合物混合。 透皮治疗剂具有优异的经皮吸收性，具有多种适用的药理活性物质，由于不存在药理活性物质的结晶，显示出良好的经皮吸收稳定性，具有良好的粘合强度，因此有利地用作透皮治疗膏药。

    Process for producing preparation for oral administration
    5.
    发明授权
    Process for producing preparation for oral administration 有权
    生产口服制剂的方法

    公开(公告)号：US08303741B2

    公开(公告)日：2012-11-06

    申请号：US12593896

    申请日：2007-12-14

    申请人： Akio Kabuto ,  Yusaku Sugiura ,  Eiji Suzuki ,  Hideaki Okabe

    发明人： Akio Kabuto ,  Yusaku Sugiura ,  Eiji Suzuki ,  Hideaki Okabe

    IPC分类号： B32B38/00 ,  B32B37/00 ,  B32B38/08

    CPC分类号： A61K9/0053 ,  A61J3/06 ,  A61K9/7007 ,  A61K31/426 ,  Y10T156/10 ,  Y10T156/1039 ,  Y10T156/1043

    摘要： A process for producing an oral preparation containing a first water-swellable gel-forming layer and a second water-swellable gel-forming layer as outermost layers, a medicine being sealed in an inner space formed by bonding the periphery of the first water-swellable gel-forming layer and the periphery of the second water-swellable gel-forming layer either directly or via an adhesive layer, the process including (a) a step of forming a first water-swellable gel-forming layer, (b) a step of forming a recess in a predetermined area of the first water-swellable gel-forming layer, (c) a step of filling the recess with a medicine to obtain a medicine-containing body, and (d) a step of forming a second water-swellable gel-forming layer over the medicine-containing body directly or via an adhesive layer so that the first water-swellable gel-forming layer and the second water-swellable gel-forming layer are bonded around the recess, and a process for continuously producing the oral preparation are disclosed. According to the above process for producing an oral preparation, an oral preparation in which the medicine is completely masked so that the medicine can be administered without a problem of bitterness and odor of the medicine can be efficiently produced without causing the medicine to deteriorate due to heat history, without a loss of the medicine, and without a limitation to the amount of the medicine to be added.

    摘要翻译： 一种制备含有第一水溶胀性凝胶形成层和第二水溶胀性凝胶形成层作为最外层的口腔制剂的方法，药物密封在内部空间中，该内部空间通过将第一水溶胀性凝胶形成层 凝胶形成层和第二水溶胀性凝胶形成层的周边直接或经由粘合剂层，该方法包括（a）形成第一水溶胀性凝胶形成层的步骤，（b）步骤 在第一水溶胀性凝胶形成层的预定区域中形成凹部，（c）用药物填充凹部以获得含药体的步骤，（d）形成第二水的步骤 直接或经由粘合剂层使药物含有体上的不​​透水凝胶形成层，使得第一水溶胀性凝胶形成层和第二水溶胀性凝胶形成层结合在凹部周围，并且连续地进行 生产口服制剂 被披露。 根据上述口服制剂的制造方法，可以有效地制造药剂完全被掩蔽的口服制剂，从而能够在不引起药物的苦味和异味的情况下给药而不会导致药物劣化 热病历史，没有药物的流失，而不限制药物的添加量。

    PROCESS FOR PRODUCING PREPARATION FOR ORAL ADMINISTRATION
    6.
    发明申请
    PROCESS FOR PRODUCING PREPARATION FOR ORAL ADMINISTRATION 有权
    生产口服药物制剂的方法

    公开(公告)号：US20100126650A1

    公开(公告)日：2010-05-27

    申请号：US12593896

    申请日：2007-12-14

    申请人： Akio Kabuto ,  Yusaku Sugiura ,  Eiji Suzuki ,  Hideaki Okabe

    发明人： Akio Kabuto ,  Yusaku Sugiura ,  Eiji Suzuki ,  Hideaki Okabe

    IPC分类号： B32B38/00 ,  B32B37/00 ,  B32B38/08

    CPC分类号： A61K9/0053 ,  A61J3/06 ,  A61K9/7007 ,  A61K31/426 ,  Y10T156/10 ,  Y10T156/1039 ,  Y10T156/1043

    摘要： A process for producing an oral preparation containing a first water-swellable gel-forming layer and a second water-swellable gel-forming layer as outermost layers, a medicine being sealed in an inner space formed by bonding the periphery of the first water-swellable gel-forming layer and the periphery of the second water-swellable gel-forming layer either directly or via an adhesive layer, the process including (a) a step of forming a first water-swellable gel-forming layer, (b) a step of forming a recess in a predetermined area of the first water-swellable gel-forming layer, (c) a step of filling the recess with a medicine to obtain a medicine-containing body, and (d) a step of forming a second water-swellable gel-forming layer over the medicine-containing body directly or via an adhesive layer so that the first water-swellable gel-forming layer and the second water-swellable gel-forming layer are bonded around the recess, and a process for continuously producing the oral preparation are disclosed. According to the above process for producing an oral preparation, an oral preparation in which the medicine is completely masked so that the medicine can be administered without a problem of bitterness and odor of the medicine can be efficiently produced without causing the medicine to deteriorate due to heat history, without a loss of the medicine, and without a limitation to the amount of the medicine to be added.

    摘要翻译： 一种制备含有第一水溶胀性凝胶形成层和第二水溶胀性凝胶形成层作为最外层的口腔制剂的方法，药物密封在内部空间中，该内部空间通过将第一水溶胀性凝胶形成层 凝胶形成层和第二水溶胀性凝胶形成层的周边直接或经由粘合剂层，该方法包括（a）形成第一水溶胀性凝胶形成层的步骤，（b）步骤 在第一水溶胀性凝胶形成层的预定区域中形成凹部，（c）用药物填充凹部以获得含药体的步骤，（d）形成第二水的步骤 直接或经由粘合剂层使药物含有体上的不​​透水凝胶形成层，使得第一水溶胀性凝胶形成层和第二水溶胀性凝胶形成层结合在凹部周围，并且连续地进行 生产口服制剂 被披露。 根据上述口服制剂的制造方法，可以有效地制造药剂完全被掩蔽的口服制剂，从而能够在不引起药物的苦味和异味的情况下给药而不会导致药物劣化 热病历史，没有药物的流失，而不限制药物的添加量。

    Blackhead-removing face pack sheet
    8.
    发明授权
    Blackhead-removing face pack sheet 失效
    黑头去除面包片

    公开(公告)号：US06190683B1

    公开(公告)日：2001-02-20

    申请号：US08919744

    申请日：1997-08-28

    申请人： Masaru Hoshi ,  Eiji Suzuki ,  Hideaki Okabe

    发明人： Masaru Hoshi ,  Eiji Suzuki ,  Hideaki Okabe

    IPC分类号： A61K970

    CPC分类号： A61Q19/00 ,  A61K8/0208

    摘要： A blackhead-removing face pack sheet with superior ease of use and blackhead-removing capacity is provided. The blackhead-removing face pack sheet 1 is formed from a laminate which comprises a gas-permeable and flexible base layer 2 and a pack material layer 3 the primary component of which is a copolymer of vinyl acetate and N-vinyl-2-pyrrolidone. The base layer 2 comprises a porous material such as a nonwoven fabric, and part of it is impregnated or embedded with the pack material constituting the pack material layer 3. This gives a high force of adhesion between the base layer 2 and the pack material layer 3.

    摘要翻译： 提供了具有优异的易用性和除黑头粉碎能力的除黑头粉刺的面包纸。 除黑头粉刺面包纸1由层叠体形成，该层压体包括透气且柔性的基底层2和主要成分为乙酸乙烯酯和N-乙烯基-2-吡咯烷酮的共聚物的包装材料层3。 基层2由无纺布等多孔质材料构成，其一部分浸渍或嵌入构成包装材料层3的包装材料。这样，在基层2和包装材料层之间产生较大的粘合力 3。