-
1.发明授权Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives 有权用于合成稠合氨基二氢噻嗪衍生物的方法和化合物公开(公告)号：US08802871B2
公开(公告)日：2014-08-12
申请号：US13795308
申请日：2013-03-12
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Branko Mitasev , Dae-Shik Kim , Huiming Zhang , Matthew J. Schnaderbeck , Christopher N. Farthing
IPC: C07D307/22
CPC classification number: C07D307/22 , C07D498/04 , C07D513/04
Abstract: Provided are compounds and methods useful for the preparation of compounds useful as inhibitors of beta-site amyloid precursor protein (APP)-cleaving enzyme.
Abstract translation: 提供了可用于制备可用作β-位淀粉样蛋白前体蛋白（APP）消除酶抑制剂的化合物的化合物和方法。
-
公开(公告)号：US11643418B2
公开(公告)日：2023-05-09
申请号：US17188819
申请日：2021-03-01
Applicant: EISAI R&D MANAGEMENT CO., LTD.
Inventor： Francis G. Fang , Dae-Shik Kim , Hyeong-Wook Choi , Charles E. Chase , Jaemoon Lee
IPC: C07D493/22 , C07F7/18 , C07D407/14 , C07D307/28 , C07D407/06 , C07D493/14
CPC classification number: C07D493/22 , C07D307/28 , C07D407/06 , C07D407/14 , C07D493/14 , C07F7/1804
Abstract: The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Homer-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.
-
3.发明授权公开(公告)号：US09783549B2
公开(公告)日：2017-10-10
申请号：US15033970
申请日：2014-11-04
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Francis G. Fang , Dae-Shik Kim , Hyeong-Wook Choi , Charles E. Chase , Jaemoon Lee
IPC: C07D493/22 , C07F7/18 , C07D307/28 , C07D407/06 , C07D493/14 , C07D407/14
CPC classification number: C07D493/22 , C07D307/28 , C07D407/06 , C07D407/14 , C07D493/14 , C07F7/1804
Abstract: The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Homer-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.
-
公开(公告)号：US12251394B2
公开(公告)日：2025-03-18
申请号：US17058817
申请日：2019-05-31
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Dae-Shik Kim , Frank Fang , Atsushi Endo , Hyeong-Wook Choi , Ming-Hong Hao , Xingfeng Bao , Kuan-Chun Huang
IPC: A61K31/7084 , A61P35/04
Abstract: Provided herein are methods for the treatment of bladder cancer.
-
公开(公告)号：US10981929B2
公开(公告)日：2021-04-20
申请号：US16313196
申请日：2017-06-30
Applicant: EISAI R&D MANAGEMENT CO., LTD.
Inventor： Charles E. Chase , Hyeong-Wook Choi , Atsushi Endo , Francis G. Fang , Dae-Shik Kim
IPC: C07D493/22
Abstract: The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditions to afford a macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides or analogs thereof and methods for preparing the same.
-
Patent Agency Ranking
公开(公告)号：US10934307B2
公开(公告)日：2021-03-02
申请号：US16833923
申请日：2020-03-30
Applicant: EISAI R&D MANAGEMENT CO., LTD.
Inventor： Francis G. Fang , Dae-Shik Kim , Hyeong-Wook Choi , Charles E. Chase , Jaemoon Lee
IPC: C07D493/22 , C07F7/18 , C07D407/14 , C07D307/28 , C07D407/06 , C07D493/14
Abstract: The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.
-
7.发明授权Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives 有权用于合成稠合氨基二氢噻嗪衍生物的方法和化合物公开(公告)号：US08962858B2
公开(公告)日：2015-02-24
申请号：US14316321
申请日：2014-06-26
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Branko Mitasev , Dae-Shik Kim , Huiming Zhang , Christopher N. Farthing
IPC: C07D498/04 , C07D307/22 , C07D513/04
CPC classification number: C07D307/22 , C07D498/04 , C07D513/04
Abstract: Provided are compounds and methods useful for the preparation of compounds useful as inhibitors of beta-site amyloid precursor protein (APP)-cleaving enzyme.
Abstract translation: 提供了可用于制备可用作β-位淀粉样蛋白前体蛋白（APP）消除酶抑制剂的化合物的化合物和方法。
-
8.发明申请METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES 有权合成氨基二氢卟吩衍生物的方法和化合物公开(公告)号：US20130197244A1
公开(公告)日：2013-08-01
申请号：US13795308
申请日：2013-03-12
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Branko Mitasev , Dae-Shik Kim , Huiming Zhang , Matthew J. Schnaderbeck , Christopher N. Farthing
IPC: C07D307/22
CPC classification number: C07D307/22 , C07D498/04 , C07D513/04
Abstract: Provided are compounds and methods useful for the preparation of compounds useful as inhibitors of beta-site amyloid precursor protein (APP)-cleaving enzyme.
Abstract translation: 提供了可用于制备可用作β-位淀粉样蛋白前体蛋白（APP）消除酶抑制剂的化合物的化合物和方法。
-
公开(公告)号：US10913749B2
公开(公告)日：2021-02-09
申请号：US16387820
申请日：2019-04-18
Applicant: EISAI R&D MANAGEMENT CO., LTD.
Inventor： Francis G. Fang , Dae-Shik Kim , Hyeong-Wook Choi , Charles E. Chase
IPC: C07D493/22 , C07F9/655
Abstract: The invention provides methods for the synthesis of a halichondrin macrolides through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.
-
公开(公告)号：US10308661B2
公开(公告)日：2019-06-04
申请号：US15571921
申请日：2016-05-09
Applicant: EISAI R&D MANAGEMENT CO., LTD.
Inventor： Francis G. Fang , Dae-Shik Kim , Hyeong-Wook Choi , Charles E. Chase
IPC: C07D493/22 , C07F9/655
Abstract: The invention provides methods for the synthesis of a halichondrin macrolides through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Homer-Wadsworth-Emmons olefination), catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.
-
-
-
-
-
-
-
-
-
Search Results
16
records
(took 0.026 seconds)
