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    CYS80 conjugated immunoglobulins
    8.
    发明授权
    CYS80 conjugated immunoglobulins 有权

    公开(公告)号：US10273310B2

    公开(公告)日：2019-04-30

    申请号：US15185879

    申请日：2016-06-17

    Applicant: Eisai R&D Management Co., Ltd.

    Inventor： Luigi Grasso ,  Jared Spidel ,  James Bradford Kline ,  Earl Albone

    IPC: C07K16/40 ,  A61K47/68 ,  A61K39/00 ,  C07K16/28 ,  C07K16/30 ,  G01N33/533

    Abstract: Provided herein are methods for generating conjugated immunoglobulins, the method comprising: decapping a cysteine at amino acid position 80 (“Cys80”) in a light chain variable region of an immunoglobulin, wherein the immunoglobulin comprises a heavy chain variable region and the light chain variable region; and conjugating a thiol-reactive compound to the Cys80, wherein the thiol-reactive compound comprises a thiol-reactive group. Antigen-binding molecules and methods for generating the same, immunoglobulins as well as nucleic acid molecules encoding the immunoglobulins and host cells comprising the nucleic acid molecules, conjugated immunoglobulins, and light chain variable regions for use in a conjugated immunoglobulin are also provided.

    CYS80 CONJUGATED IMMUNOGLOBULINS
    9.
    发明申请
    CYS80 CONJUGATED IMMUNOGLOBULINS 有权

    公开(公告)号：US20230001004A1

    公开(公告)日：2023-01-05

    申请号：US17464815

    申请日：2021-09-02

    Applicant: Eisai R&D Management Co., Ltd.

    Inventor： Luigi Grasso ,  Jared Spidel ,  James Bradford Kline ,  Earl Albone

    IPC: A61K47/68 ,  C07K16/28 ,  C07K16/30 ,  C07K16/40 ,  G01N33/533

    Abstract: Provided herein are methods for generating conjugated immunoglobulins, the method comprising: decapping a cysteine at amino acid position 80 (“Cys80”) in a light chain variable region of an immunoglobulin, wherein the immunoglobulin comprises a heavy chain variable region and the light chain variable region; and conjugating a thiol-reactive compound to the Cys80, wherein the thiol-reactive compound comprises a thiol-reactive group. Antigen-binding molecules and methods for generating the same, immunoglobulins as well as nucleic acid molecules encoding the immunoglobulins and host cells comprising the nucleic acid molecules, conjugated immunoglobulins, and light chain variable regions for use in a conjugated immunoglobulin are also provided.

    Cys80 conjugated immunoglobulins
    10.
    发明授权
    Cys80 conjugated immunoglobulins 有权

    公开(公告)号：US11129904B2

    公开(公告)日：2021-09-28

    申请号：US16353326

    申请日：2019-03-14

    Applicant: Eisai R&D Management Co., Ltd.

    Inventor： Luigi Grasso ,  Jared Spidel ,  James Bradford Kline ,  Earl Albone

    IPC: A61K47/68 ,  C07K16/28 ,  C07K16/30 ,  C07K16/40 ,  A61K39/00 ,  G01N33/533

    Abstract: Provided herein are methods for generating conjugated immunoglobulins, the method comprising: decapping a cysteine at amino acid position 80 (“Cys80”) in a light chain variable region of an immunoglobulin, wherein the immunoglobulin comprises a heavy chain variable region and the light chain variable region; and conjugating a thiol-reactive compound to the Cys80, wherein the thiol-reactive compound comprises a thiol-reactive group. Antigen-binding molecules and methods for generating the same, immunoglobulins as well as nucleic acid molecules encoding the immunoglobulins and host cells comprising the nucleic acid molecules, conjugated immunoglobulins, and light chain variable regions for use in a conjugated immunoglobulin are also provided.

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