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公开(公告)号：US11753669B2
公开(公告)日：2023-09-12
申请号：US17159655
申请日：2021-01-27
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Jared Spidel , Earl Albone
CPC classification number: C12P21/02 , A61K47/68 , A61K47/6803 , A61K47/6811 , C07K16/00 , C12Y203/02013 , C07K2317/40 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/53 , C07K2317/55
Abstract: Provided herein are conjugated immunoglobulins and methods for generating conjugated immunoglobulins using a microbial transglutaminase.
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公开(公告)号：US11572414B2
公开(公告)日：2023-02-07
申请号：US17091819
申请日：2020-11-06
Applicant: EISAI R&D MANAGEMENT CO., LTD.
Inventor： Earl F. Albone , Jared Spidel
IPC: A61P35/00 , C07K16/30 , A61K47/68 , A61K47/60 , A61K31/357 , G01N33/574 , A61K39/00
Abstract: Antibodies, antigen-binding fragments, and conjugates (e.g., antibody-drug conjugates such as those comprising eribulin) thereof that bind to mesothelin are disclosed. The disclosure further relates to methods and compositions for use in the treatment of cancer by administering the compositions provided herein.
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公开(公告)号：US20160046707A1
公开(公告)日：2016-02-18
申请号：US14816989
申请日：2015-08-03
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Toshio Imai , James Bradford Kline , Tetsu Kawano , Luigi Grasso , Yoshimasa Sakamoto , Jared Spidel , Miyuki Nishimura , Kenzo Muramoto , Tatsuo Horizoe
CPC classification number: C07K16/24 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , G01N33/6863 , G01N2333/521
Abstract: The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer.
Abstract translation: 本发明涉及对人CC趋化因子配体20（CCL20）具有结合特异性的新型人源化，嵌合和鼠抗体。 本发明还涉及所述抗体的重链和轻链。 本发明还涉及分离的核酸，重组载体和宿主细胞，其包含编码所述抗体的重链和/或轻链的序列，以及制备所述抗体的方法。 本发明的抗CCL20抗体可用于治疗例如炎性和自身免疫性疾病和癌症的治疗应用。
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公开(公告)号：US20220088212A1
公开(公告)日：2022-03-24
申请号：US17408003
申请日：2021-08-20
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Jared Spidel , Earl Albone
Abstract: Provided herein are conjugated immunoglobulins and methods for generating conjugated immunoglobulins using a microbial transglutaminase.
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公开(公告)号：US20210171998A1
公开(公告)日：2021-06-10
申请号：US17159655
申请日：2021-01-27
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Jared Spidel , Earl Albone
Abstract: Provided herein are conjugated immunoglobulins and methods for generating conjugated immunoglobulins using a microbial transglutaminase.
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Patent Agency Ranking
公开(公告)号：US09133273B2
公开(公告)日：2015-09-15
申请号：US13924433
申请日：2013-06-21
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Toshio Imai , James Bradford Kline , Tetsu Kawano , Luigi Grasso , Yoshimasa Sakamoto , Jared Spidel , Miyuki Nishimura , Kenzo Muramoto , Tatsuo Horizoe
CPC classification number: C07K16/24 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , G01N33/6863 , G01N2333/521
Abstract: The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer.
Abstract translation: 本发明涉及对人CC趋化因子配体20（CCL20）具有结合特异性的新型人源化，嵌合和鼠抗体。 本发明还涉及所述抗体的重链和轻链。 本发明还涉及分离的核酸，重组载体和宿主细胞，其包含编码所述抗体的重链和/或轻链的序列，以及制备所述抗体的方法。 本发明的抗CCL20抗体可用于治疗例如炎性和自身免疫性疾病和癌症的治疗应用。
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公开(公告)号：US12214050B2
公开(公告)日：2025-02-04
申请号：US17408003
申请日：2021-08-20
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Jared Spidel , Earl Albone
Abstract: Provided herein are conjugated immunoglobulins and methods for generating conjugated immunoglobulins using a microbial transglutaminase.
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公开(公告)号：US20240034777A1
公开(公告)日：2024-02-01
申请号：US18149905
申请日：2023-01-04
Applicant: Eisai R&D Management Co., Ltd , UCL Business LTD
Inventor： Malcolm Ian Roberts , James Martin Staddon , Hettihewage Alfred Rohan De Silva , Jared Spidel , Hirofumi Aoyagi , Shigeru Akasofu , Yutaka Hashizume , Kishan Agarwala
CPC classification number: C07K16/18 , C07K14/4711 , C12N15/85 , A61P25/28 , C12N15/62 , A61K39/3955 , C07K2317/24 , C12N2015/8518 , C07K2317/56 , C07K2317/34 , C07K2317/76 , C07K2317/565
Abstract: Provided herein are antibodies that specifically bind Tau and methods of using the same.
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公开(公告)号：US10829547B2
公开(公告)日：2020-11-10
申请号：US16161586
申请日：2018-10-16
Applicant: Eisai R&D Management Co., Ltd. , UCL Business LTD
Inventor： Malcolm Ian Roberts , James Martin Staddon , Hettihewage Alfred Rohan De Silva , Jared Spidel , Hirofumi Aoyagi , Shigeru Akasofu , Yutaka Hashizume , Kishan Agarwala
Abstract: Provided herein are antibodies that specifically bind Tau and methods of using the same.
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公开(公告)号：US20190112365A1
公开(公告)日：2019-04-18
申请号：US16217360
申请日：2018-12-12
Applicant: Eisai R&D Management Co., Ltd. , UCL Business PLC
Inventor： Malcolm Ian Roberts , James Martin Staddon , Hettihewage Alfred Rohan De Silva , Jared Spidel , Hirofumi Aoyagi , Shigeru Akasofu , Yutaka Hashizume , Kishan Agarwala
CPC classification number: C07K16/18 , A61K39/3955 , A61K2039/505 , A61P25/28 , C07K14/4711 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/62 , C12N15/85 , C12N2015/8518
Abstract: Provided herein are antibodies that specifically bind Tau and methods of using the same.
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