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公开(公告)号：US20140155452A1
公开(公告)日：2014-06-05
申请号：US14173170
申请日：2014-02-05
IPC分类号： C07D231/22
CPC分类号： C07D231/22 , C07D231/20
摘要： The present invention provides compounds of Formula I: along with pharmaceutical compositions containing the same, and methods of use thereof in subjects in need of treatment.
摘要翻译： 本发明提供式I化合物以及含有其的药物组合物及其在需要治疗的受试者中的使用方法。
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公开(公告)号：US11130758B2
公开(公告)日：2021-09-28
申请号：US16845594
申请日：2020-04-10
发明人： Roch Boivin , Eric Carlson , Atsushi Endo , Hans Hansen , Lynn D. Hawkins , Sally Ishizaka , Matthew Mackey , Sridhar Narayan , Takashi Satoh , Shawn Schiller
IPC分类号： C07D487/04 , C07D471/04 , A61K31/519 , A61K31/55
摘要： Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
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公开(公告)号：US10912774B2
公开(公告)日：2021-02-09
申请号：US16717080
申请日：2019-12-17
发明人： Dominic Reynolds , Ming-Hong Hao , John Wang , Sudeep Prajapati , Takashi Satoh , Anand Selvaraj
IPC分类号： A61K31/505 , A61K31/506 , A61K31/5377
摘要： Provided herein are compounds of Formula I useful as FGFR4 inhibitors, as well as methods of use of the same.
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公开(公告)号：US09730931B2
公开(公告)日：2017-08-15
申请号：US15221018
申请日：2016-07-27
发明人： Dominic Reynolds , Ming-Hong Hao , John Wang , Sudeep Prajapati , Takashi Satoh , Anand Selvaraj
IPC分类号： A61K31/505 , C07D239/48 , C07D405/12 , C07D413/12 , A61K31/506 , C07C53/18 , C07D401/12 , C07D403/12 , A61K31/5377
CPC分类号： A61K31/505 , A61K31/506 , A61K31/5377 , C07C53/18 , C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Provided herein are compounds of Formula I useful as FGFR4 inhibitors, as well as methods of use of the same.
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公开(公告)号：US09434697B2
公开(公告)日：2016-09-06
申请号：US15000659
申请日：2016-01-19
发明人： Dominic Reynolds , Ming-Hong Hao , John Wang , Sudeep Prajapati , Takashi Satoh , Anand Selvaraj
IPC分类号： A61K31/505 , C07D239/48 , C07D401/12 , C07C53/18 , C07D403/12 , C07D413/12 , A61K31/506
CPC分类号： A61K31/505 , A61K31/506 , A61K31/5377 , C07C53/18 , C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Provided herein are compounds of Formula I useful as FGFR4 inhibitors, as well as methods of use of the same.
摘要翻译： 本文提供了可用作FGFR4抑制剂的式I化合物，以及其用途的方法。
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公开(公告)号：US20160130237A1
公开(公告)日：2016-05-12
申请号：US15000659
申请日：2016-01-19
发明人： Dominic Reynolds , Ming-Hong Hao , John Wang , Sudeep Prajapati , Takashi Satoh , Anand Selvaraj
IPC分类号： C07D239/48 , C07D413/12 , C07D403/12 , C07D401/12 , C07C53/18
CPC分类号： A61K31/505 , A61K31/506 , A61K31/5377 , C07C53/18 , C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Provided herein are compounds of Formula I useful as FGFR4 inhibitors, as well as methods of use of the same.
摘要翻译： 本文提供了可用作FGFR4抑制剂的式I化合物，以及其用途的方法。
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公开(公告)号：US20160030430A1
公开(公告)日：2016-02-04
申请号：US14806174
申请日：2015-07-22
发明人： Roch Boivin , Eric Carlson , Atsushi Endo , Hans Hansen , Lynn D. Hawkins , Sally Ishizaka , Matthew Mackey , Sridhar Narayan , Takashi Satoh , Shawn Schiller
IPC分类号： A61K31/519
CPC分类号： C07D471/04 , A61K31/519 , A61K31/55 , C07D487/04 , Y02P20/582
摘要： Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis
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公开(公告)号：US20180273532A1
公开(公告)日：2018-09-27
申请号：US15841767
申请日：2017-12-14
发明人： Roch Boivin , Eric Carlson , Atsushi Endo , Hans Hansen , Lynn D. Hawkins , Sally Ishizaka , Matthew Mackey , Sridhar Narayan , Takashi Satoh , Shawn Schiller
IPC分类号： C07D471/04 , A61K31/55 , C07D487/04 , A61K31/519
CPC分类号： C07D471/04 , A61K31/519 , A61K31/55 , C07D487/04 , Y02P20/582
摘要： Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
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公开(公告)号：US11498916B2
公开(公告)日：2022-11-15
申请号：US16722838
申请日：2019-12-20
发明人： George Moniz , Kristen Sanders , Arani Chanda , Kenshi Yoshida , Ming-Hong Hao , Dominic Reynolds , Sudeep Prajapati , Anand Selvaraj , Takashi Satoh , John Wang
IPC分类号： C07D403/12 , C07D239/48 , A61K31/505
摘要： A number of crystalline forms of N-(2-((6-(3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-methylureido)pyrimidin-4-yl)amino)-5-(4-ethylpiperazin-1-y1)phenyl)acrylamide are provided. These include a crystalline free base form, a crystalline monohydrochloride salt form, a crystalline dihydrochloride salt form, and a crystalline ethanesulfonate salt form. Methods of making and using crystalline compounds are also provided.
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公开(公告)号：US09850242B2
公开(公告)日：2017-12-26
申请号：US15233520
申请日：2016-08-10
发明人： Roch Boivin , Eric Carlson , Atsushi Endo , Hans Hansen , Lynn D. Hawkins , Sally Ishizaka , Matthew Mackey , Sridhar Narayan , Takashi Satoh , Shawn Schiller
IPC分类号： A01N43/90 , A61K31/519 , C07D471/04 , C07D487/04 , A61K31/55
CPC分类号： C07D471/04 , A61K31/519 , A61K31/55 , C07D487/04 , Y02P20/582
摘要： Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
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