公开(公告)号：US20190231720A1

公开(公告)日：2019-08-01

申请号：US16260350

申请日：2019-01-29

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Keigo Tanaka ,  Tasuku Ishida ,  Masayuki Miyano ,  Raku Shinkyo

IPC: A61K31/166 ,  A61P19/10 ,  A61P29/00 ,  A61P7/06

CPC classification number: A61K31/166 ,  A61P7/06 ,  A61P19/10 ,  A61P29/00 ,  C07C233/73 ,  C07C235/60

Abstract: The present invention provides a compound represented by formula (1): or pharmaceutically acceptable salt thereof, wherein X and Y are the same or different from each other and represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group, wherein the C1-6 alkoxy group may be substituted with a C1-6 alkoxy group, and Z and W are the same or different from each other and represent a hydrogen atom, a halogen atom, or a C1-6 alkyl group.

公开(公告)号：US10406126B2

公开(公告)日：2019-09-10

申请号：US16260350

申请日：2019-01-29

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Keigo Tanaka ,  Tasuku Ishida ,  Masayuki Miyano ,  Raku Shinkyo

IPC: C07C233/73 ,  C07C235/60 ,  A61K31/166 ,  A61P7/06 ,  A61P29/00 ,  A61P19/10

Abstract: The present invention provides a compound represented by formula (1): or pharmaceutically acceptable salt thereof, wherein X and Y are the same or different from each other and represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group, wherein the C1-6 alkoxy group may be substituted with a C1-6 alkoxy group, and Z and W are the same or different from each other and represent a hydrogen atom, a halogen atom, or a C1-6 alkyl group.

公开(公告)号：US20220135942A1

公开(公告)日：2022-05-05

申请号：US17435478

申请日：2020-03-27

Applicant: NAGASAKI UNIVERSITY ,  Eisai R&D Management Co., Ltd.

Inventor： Yusuke Sakai ,  Susumu EGUCHI ,  Tomohiko ADACHI ,  Yu HUANG ,  Raku Shinkyo ,  Saki SAGARA ,  Daichi ONOZATO

IPC: C12N5/071

Abstract: A cultured tissue, comprising: glandular cells; glandular cavities formed from the glandular cells; and ducts formed from epithelial cells, wherein the glandular cavities and the ducts are functionally connected ex vivo.