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    STORAGE CONTAINER
    1.
    发明申请
    STORAGE CONTAINER 有权

    公开(公告)号：US20220174942A1

    公开(公告)日：2022-06-09

    申请号：US17681432

    申请日：2022-02-25

    申请人： Nagasaki University

    发明人： Masafumi UEMATSU ,  Takashi KITAOKA

    IPC分类号： A01N1/02 ,  A61F2/14 ,  A61F2/00

    摘要： Provided is a storage container for storing a cornea specimen in which an endothelium and an epithelium of a cornea can be immersed and stored in different storage solutions. The storage container 1A is provided with a specimen-supporting portion 3A which contains a first cornea exposure portion 31a and a second cornea exposure portion 31b that expose a cornea part 101, the specimen-supporting portion supporting a scleral rim 102 at an outer circumferential side of the first and second cornea exposure portions 31a, 31b; a first chamber 20a to which an endothelium side of the cornea part 101 in the cornea specimen 100 is exposed, the scleral rim 102 of the cornea specimen 100 being supported by the specimen-supporting portion 3A, and the first chamber containing a first storage solution 60a; and a second chamber 20b to which an epithelium side of the cornea part 101 in the cornea specimen 100 is exposed, the scleral rim 102 of the cornea specimen 100 being supported by the specimen-supporting portion, the second chamber being divided from the first chamber 20a by the specimen-supporting portion 3A, and the second chamber containing a second storage solution 60b that differs from the first storage solution 60a, wherein the storage container is configured to prevent the first and second storage solutions 60a, 60b from being circulated between the first and second chambers 20a, 20b.

    RIGID ENDOSCOPE COVER AND ENDOSCOPE UNIT
    5.
    发明申请
    RIGID ENDOSCOPE COVER AND ENDOSCOPE UNIT 有权

    公开(公告)号：US20210228069A1

    公开(公告)日：2021-07-29

    申请号：US17050943

    申请日：2019-06-12

    申请人： TRYTEC Co. Ltd. ,  NAGASAKI UNIVERSITY

    发明人： Keitaro MATSUMOTO ,  Katsunori TAKAGI ,  Takeshi NAGAYASU ,  Hiroshi TAKEZAKI

    IPC分类号： A61B1/12 ,  A61B1/00

    摘要： A cover 20 for covering a circumferential portion of an outer circumferential surface of a rigid endoscope 10 having an observation window portion 14 provided at a tip thereof includes a flexible outer cover member 22 covering the circumferential portion of the circumferential surface of the rigid endoscope 10 and a tubular member 26, provided inside the outer cover member 22, through which a cleaning fluid to be supplied from a base end of the rigid endoscope 10 to the observation window portion 14 of the rigid endoscope 10 flows inside, and the outer cover member 22 is attached to the outer circumference surface of the rigid endoscope 10 by flexing the outer cover member 22.

    Instrument for delivering a surgical thread
    6.
    发明授权
    Instrument for delivering a surgical thread 有权

    公开(公告)号：US10130357B2

    公开(公告)日：2018-11-20

    申请号：US15129698

    申请日：2015-03-26

    申请人： Nagasaki University

    发明人： Susumu Eguchi ,  Tamotu Kuroki ,  Taiichiro Kosaka ,  Takakazu Ishimatu ,  Syunji Moromugi

    IPC分类号： A61B17/04 ,  A61B17/06 ,  A61B17/12 ,  A61B17/00

    摘要： To reduce the risk of damaging organs in a body while delivering a thread during surgery, an instrument for delivering a surgical thread has a grip, an outer cylinder fixed the grip, a hollow needle extending inside the outer cylinder and being configured to be moved relative to the outer cylinder in an axial direction and a loop configured to be housed in the outer cylinder. An end of the outer cylinder is bent in a state where force is not applied. The hollow needle is exposed from the outer cylinder when puncturing skin or etc., and the hollow needle is housed in the outer cylinder when it travels near organs which should not be damaged.

    Therapeutic agent for Alzheimer's disease
    7.
    发明授权
    Therapeutic agent for Alzheimer's disease 有权

    公开(公告)号：US09980937B2

    公开(公告)日：2018-05-29

    申请号：US15460846

    申请日：2017-03-16

    申请人： NAGASAKI UNIVERSITY

    发明人： Nobuhisa Iwata ,  Keiro Shirotani ,  Masashi Asai ,  Takashi Tanaka

    IPC分类号： A61K31/35 ,  A61K31/352 ,  A61K31/353

    CPC分类号： A61K31/352 ,  A61K31/353

    摘要： The present invention aims to provide a pharmaceutical agent for the prophylaxis and/or treatment of Alzheimer's disease, which has a novel action mechanism and shows less side effects. A polyphenol derivative having liposolubility enhanced by the introduction of at least one kind of a liposoluble group selected from the group consisting of a chain saturated hydrocarbon group, a chain unsaturated hydrocarbon group, a cyclic saturated hydrocarbon group, a cyclic unsaturated hydrocarbon group, an aromatic hydrocarbon group, a liposoluble vitamin residue and a sterol residue has an action to potentiate neprilysin activity, and is useful as a pharmaceutical agent for the prophylaxis and/or treatment of Alzheimer's disease.

    Ameliorating agent for blood-brain barrier dysfunction
    9.
    发明授权
    Ameliorating agent for blood-brain barrier dysfunction 有权

    公开(公告)号：US09617324B2

    公开(公告)日：2017-04-11

    申请号：US14378323

    申请日：2013-02-13

    申请人： Nagasaki University ,  Shin Nippon Biomedical Laboratories, Ltd.

    发明人： Hiroshi Ueda

    IPC分类号： C07K14/575 ,  A61K38/08 ,  A61K45/06 ,  A61K38/00

    CPC分类号： C07K14/57581 ,  A61K38/00 ,  A61K38/08 ,  A61K45/06

    摘要： To provide a peptide which can be produced and processed more readily compared with prothymosin α , which is conventionally known, or a peptide thereof and has an activity at a level equivalent to or higher than that of prothymosin α or a peptide thereof. The present invention provides an ameliorating agent for blood-organ barrier dysfunction, a therapeutic agent for diseases associated with blood-organ barrier dysfunction or ischemic diseases or a nerve cell death inhibitor, each comprising, as an active ingredient, a peptide comprising the amino acid sequence represented by SEQ ID NO: 1 or a peptide having substantially the same function as that of the aforementioned peptide.

    HB-EGF DEFICIENT TRANSGENIC ANIMAL AND PRODUCTION METHOD THEREOF
    10.
    发明申请
    HB-EGF DEFICIENT TRANSGENIC ANIMAL AND PRODUCTION METHOD THEREOF 审中-公开
    HB-EGF缺乏转基因动物及其生产方法

    公开(公告)号：US20130269045A1

    公开(公告)日：2013-10-10

    申请号：US13756247

    申请日：2013-01-31

    申请人： Nagasaki University ,  Shin Nippon Biomedical Laboratories, Ltd.

    发明人： Hiroshi Ueda

    IPC分类号： A61K49/00

    CPC分类号： A61K49/0008 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2217/15 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/0356 ,  C07K14/485

    摘要： A transgenic animal other than human in which neuropsychiatric disorder condition is developed by the deletion of an HB-EGF gene is obtained. The present invention relates to a transgenic animal other than human in which an HB-EGF gene is deficient and neuropsychiatric disorder condition is developed, and a production method thereof, and a method for screening a therapeutic agent for neuropsychiatric disorder. As a transgenic animal in accordance with the present invention, a transgenic animal in which an HB-EGF gene is specifically deficient in the spiny neurons (striatum, and hippocampus) can be obtained by crossbreeding a transgenic animal that contains a genotype of Gng7(+/cre), and a transgenic animal that contains a genotype of Hb-egf(flox/flox).

    摘要翻译： 获得通过缺失HB-EGF基因产生神经精神障碍病症的人以外的转基因动物。 本发明涉及其中HB-EGF基因缺乏并且发展神经精神障碍病症的人以外的转基因动物及其制备方法以及用于筛选神经精神障碍治疗剂的方法。 作为根据本发明的转基因动物，其中HB-EGF基因特异性缺陷多刺神经元（纹状体和海马）的转基因动物可以通过杂交包含Gng7基因型（+ / cre），以及含有Hb-egf（flox / flox）基因型的转基因动物。