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公开(公告)号：US06464992B2
公开(公告)日：2002-10-15
申请号：US09832571
申请日：2001-04-11
IPC分类号： A61K744
CPC分类号： A61Q19/00 , A61K8/355 , A61K8/37 , A61K8/44 , A61K8/4986 , A61K8/606 , A61K8/673 , A61K8/675 , A61K8/676 , A61K2800/782 , A61Q11/00
摘要： The invention involves methods and compositions useful in delivering micronutrients to cells. By formulating the micronutrient in the form of an ester that is convertible to the active form of the micronutrient, one can combine it with a co-ester that inhibits esterases, so that the micronutrient can reach the targeted cells prior to degradation. Both methods and compositions are described.
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公开(公告)号：US06924299B2
公开(公告)日：2005-08-02
申请号：US09834228
申请日：2001-04-12
IPC分类号： A61K8/37 , A61K31/235 , A61K31/445 , A61Q19/10 , A61K33/44
CPC分类号： A61K31/445 , A61K8/37 , A61K31/235 , A61Q19/10
摘要： The invention discloses compositions and methods which are useful in improving delivery of oxygen to cells. The compositions require at least one derivative of a compound. The derivatives are chosen to have log P values below about 6.0.
摘要翻译： 本发明公开了可用于改善向细胞递送氧气的组合物和方法。 所述组合物需要化合物的至少一种衍生物。 选择衍生物使日志P值低于约6.0。
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3.发明授权Topical formulations for the transdermal delivery of niacin and methods of treating hyperlipidemia 有权用于透皮给药烟酸的局部制剂和治疗高脂血症的方法公开(公告)号：US06677361B2
公开(公告)日：2004-01-13
申请号：US09836843
申请日：2001-04-16
IPC分类号： A61K314406
CPC分类号： A61K9/7023 , A61K31/44 , A61K31/445 , A61K31/455 , Y10S514/824
摘要： Niacin and niacin prodrugs are topically administered as suitable formulations to device for impoving the lipid profiles of subjects, preferably humans.
摘要翻译： 烟酸和烟酸前药被局部施用作为适合制剂的装置，以刺激受试者，优选人的脂质谱。
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4.发明授权Method for treating hair growth disorders, such as female pattern alopecia, and compositions useful therefore 有权用于治疗头发生长障碍的方法，例如女性脱发，以及因此有用的组合物公开(公告)号：US08114390B2
公开(公告)日：2012-02-14
申请号：US11922378
申请日：2006-06-26
IPC分类号： A61Q5/00
摘要： The invention relates to formulations useful in treating hair disorders, improving the health of hair, increasing hair growth, and in increasing the niacin content of hair follicles. Nicotinic acid alkyl esters having a straight chain alkyl group of from 1 to 22 methylene units, preferably from 6 to 16 methylene units, and most preferably from 8 to 14 methyl units, may be used, alone or in combinations for treating these conditions.
摘要翻译： 本发明涉及用于治疗头发紊乱，改善头发健康，增加毛发生长以及增加毛囊中烟酸含量的制剂。 具有1至22个亚甲基单元，优选6至16个亚甲基单元，最优选8至14个甲基单元的直链烷基的烟酸烷基酯可以单独使用或组合用于处理这些条件。
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5.发明授权Method for treating hair growth disorders, such as female pattern alopecia, and compositions useful therefore 有权用于治疗头发生长障碍的方法，例如女性脱发，以及因此有用的组合物公开(公告)号：US08790626B2
公开(公告)日：2014-07-29
申请号：US13305079
申请日：2011-11-28
摘要： The invention relates to formulations useful in treating hair disorders, improving the health of hair, increasing hair growth, and in increasing the niacin content of hair follicles. Nicotinic acid alkyl esters having a straight chain alkyl group of from 1 to 22 methylene units, preferably from 6 to 16 methylene units, and most preferably from 8 to 14 methyl units, may be used, alone or in combinations for treating these conditions.
摘要翻译： 本发明涉及用于治疗头发紊乱，改善头发健康，增加毛发生长以及增加毛囊中烟酸含量的制剂。 具有1至22个亚甲基单元，优选6至16个亚甲基单元，最优选8至14个甲基单元的直链烷基的烟酸烷基酯可以单独使用或组合用于处理这些条件。
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公开(公告)号：US09642845B2
公开(公告)日：2017-05-09
申请号：US12449793
申请日：2008-02-27
IPC分类号： A01N43/40 , A61K31/435 , A61K31/455 , A61K8/67 , A61K31/203 , A61Q19/00
CPC分类号： A61K31/455 , A61K8/671 , A61K8/675 , A61K31/203 , A61K2800/75 , A61K2800/88 , A61K2800/884 , A61Q19/00 , A61K2300/00
摘要： The invention relates to the use of nicotinic acid alkyl esters, especially myristyl nicotinate, to inhibit side effects associated with retinoic acid therapy. Also a part of the invention is a method for improving skin cell differentiation by administering the nicotinic acid alkyl ester in an amount sufficient to increase expression of caspase 14 and filaggrin. Deficiencies in expression of these molecules can be treated in this way as well.
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7.发明申请METHOD FOR TREATING HAIR GROWTH DISORDERS, SUCH AS FEMALE PATTERN ALOPECIA, AND COMPOSITIONS USEFUL THEREFORE 有权用于治疗头发生长障碍的方法，如母体型ALOPECIA及其组合物公开(公告)号：US20120093739A1
公开(公告)日：2012-04-19
申请号：US13305079
申请日：2011-11-28
IPC分类号： A61K31/455 , A61P17/14 , A61K9/12
摘要： The invention relates to formulations useful in treating hair disorders, improving the health of hair, increasing hair growth, and in increasing the niacin content of hair follicles. Nicotinic acid alkyl esters having a straight chain alkyl group of from 1 to 22 methylene units, preferably from 6 to 16 methylene units, and most preferably from 8 to 14 methyl units, may be used, alone or in combinations for treating these conditions.
摘要翻译： 本发明涉及用于治疗头发紊乱，改善头发健康，增加毛发生长以及增加毛囊中烟酸含量的制剂。 具有1至22个亚甲基单元，优选6至16个亚甲基单元，最优选8至14个甲基单元的直链烷基的烟酸烷基酯可以单独使用或组合用于处理这些条件。
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8.发明申请METHOD FOR ALLEVIATING SIDE EFFECTS OF RETINOIC ACID THERAPY AND/OR IMPROVING EFFICACY WITHOUT INTERFERING WITH EFFICACY 审中-公开用于抑制无效酸治疗的副作用和/或改善效率而不影响功效的方法公开(公告)号：US20100173957A1
公开(公告)日：2010-07-08
申请号：US12449793
申请日：2008-02-27
IPC分类号： A61K31/44
CPC分类号： A61K31/455 , A61K8/671 , A61K8/675 , A61K31/203 , A61K2800/75 , A61K2800/88 , A61K2800/884 , A61Q19/00 , A61K2300/00
摘要： The invention relates to the use of nicotinic acid alkyl esters, especially myristyl nicotinate, to inhibit side effects associated with retinoic acid therapy. Also a part of the invention is a method for improving skin cell differentiation by administering the nicotinic acid alkyl ester in an amount sufficient to increase expression of caspase 14 and filaggrin. Deficiencies in expression of these molecules can be treated in this way as well.
摘要翻译： 本发明涉及烟酸烷基酯，特别是肉豆蔻酸烟酸酯抑制与视黄酸治疗相关的副作用的用途。 本发明的一部分也是通过以足以增加半胱天冬酶14和丝聚蛋白表达的量施用烟酸烷基酯来改善皮肤细胞分化的方法。 也可以以这种方式处理这些分子的表达缺陷。
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9.发明申请Method for Treating Hair Growth Disorders, Such as Female Pattern Alopecia, and Compositions Useful Therefore 有权治疗头发生长障碍的方法，如女性型脱发，以及有用的组合物公开(公告)号：US20090318508A1
公开(公告)日：2009-12-24
申请号：US11922378
申请日：2006-06-26
IPC分类号： A61K31/455
摘要： The invention relates to formulations useful in treating hair disorders, improving the health of hair, increasing hair growth, and in increasing the niacin content of hair follicles. Nicotinic acid alkyl esters having a straight chain alkyl group of from 1 to 22 methylene units, preferably from 6 to 16 methylene units, and most preferably from 8 to 14 methyl units, may be used, alone or in combinations for treating these conditions.
摘要翻译： 本发明涉及用于治疗头发紊乱，改善头发健康，增加毛发生长以及增加毛囊中烟酸含量的制剂。 具有1至22个亚甲基单元，优选6至16个亚甲基单元，最优选8至14个甲基单元的直链烷基的烟酸烷基酯可以单独使用或组合用于处理这些条件。
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10.发明申请METHODS FOR FABRICATING CONTACTS OF SEMICONDUCTOR DEVICE STRUCTURES AND METHODS FOR DESIGNING SEMICONDUCTOR DEVICE STRUCTURES 有权用于制造半导体器件结构的接触的方法和用于设计半导体器件结构的方法公开(公告)号：US20110223761A1
公开(公告)日：2011-09-15
申请号：US13113468
申请日：2011-05-23
申请人： John K. Lee , Hyuntae Kim , Richard L. Stocks , Luan Tran
发明人： John K. Lee , Hyuntae Kim , Richard L. Stocks , Luan Tran
IPC分类号： H01L21/768 , G06F17/50
CPC分类号： H01L21/76816 , H01L27/10888 , H01L2924/0002 , H01L2924/00
摘要： Methods for fabricating contacts of semiconductor device structures include forming a dielectric layer over a semiconductor substrate with active-device regions spaced at a first pitch, forming a first plurality of substantially in-line apertures over every second active-device region of the active-device regions, and forming a second plurality of substantially in-line apertures laterally offset from apertures of the first plurality over active-device regions over which apertures of the first plurality are not located. Methods for designing semiconductor device structures include forming at least two laterally offset sets of contacts over a substrate including active-device regions at a first pitch, the contacts being formed at a second pitch that is about twice the first pitch.
摘要翻译： 用于制造半导体器件结构的触点的方法包括在半导体衬底上形成介电层，所述有源器件区域以第一间距隔开，在有源器件的每个第二有源器件区域上形成第一多个基本上一字排列的孔 并且形成第二多个基本上在线的孔，所述第二多个基本上在线的孔横向偏离所述第一多个的主动装置区域上的所述第一多个孔的孔不在其上的位置。 设计半导体器件结构的方法包括在包括有源器件区的第一间距的衬底上形成至少两个横向偏移的触点组，所述触点以大约是第一间距的两倍的第二间距形成。
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