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公开(公告)号：US20080107741A1
公开(公告)日：2008-05-08
申请号：US11928278
申请日：2007-10-30
申请人： Elaine Merisko-Liversidge , H. Bosch , Greta Cary , John Pruitt , Tuula Ryde , Rajeev Jain , Amy Walters
发明人： Elaine Merisko-Liversidge , H. Bosch , Greta Cary , John Pruitt , Tuula Ryde , Rajeev Jain , Amy Walters
CPC分类号： A61K31/00 , A61K9/145 , A61K9/146 , A61K9/148 , A61K31/565
摘要： Nanoparticulate compositions comprising at least one poorly soluble angiogenesis inhibitor and at least one surface stabilizer are described. The nanoparticulate compositions have an average particle size of less than about 2000 nm. The invention also describes methods of making and using such compositions.
摘要翻译： 描述包含至少一种难溶性血管发生抑制剂和至少一种表面稳定剂的纳米颗粒组合物。 纳米颗粒组合物具有小于约2000nm的平均粒度。 本发明还描述了制备和使用这些组合物的方法。
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公开(公告)号：US20080050461A1
公开(公告)日：2008-02-28
申请号：US11928250
申请日：2007-10-30
申请人： Elaine Merisko-Liversidge , H. William Bosch , Greta Cary , John Pruitt , Tuula Ryde , Rajeev Jain , Amy Walters
发明人： Elaine Merisko-Liversidge , H. William Bosch , Greta Cary , John Pruitt , Tuula Ryde , Rajeev Jain , Amy Walters
IPC分类号： A61K31/565 , A61K36/00 , A61K38/02 , A61K9/14
CPC分类号： A61K31/00 , A61K9/145 , A61K9/146 , A61K9/148 , A61K31/565
摘要： Nanoparticulate compositions comprising at least one poorly soluble angiogenesis inhibitor and at least one surface stabilizer are described. The nanoparticulate compositions have an average particle size of less than about 2000 nm. The invention also describes methods of making and using such compositions.
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公开(公告)号：US20100329976A1
公开(公告)日：2010-12-30
申请号：US12870749
申请日：2010-08-27
申请人： Elaine Merisko-Liversidge , H. William Bosch , Greta G. Cary , John Pruitt , Tuula Ryde , Rajeev Jain , Amy Walters
发明人： Elaine Merisko-Liversidge , H. William Bosch , Greta G. Cary , John Pruitt , Tuula Ryde , Rajeev Jain , Amy Walters
IPC分类号： A61K31/565 , A61K9/00 , A61K9/20 , A61K9/48 , A61K38/16 , A61K31/7052 , A61K49/00 , A61K36/00 , A61K36/886 , A61K36/82 , A61K36/55 , A61K35/60 , A61K35/00 , A61K39/00 , A61P9/00 , A61P35/00
CPC分类号： A61K31/00 , A61K9/145 , A61K9/146 , A61K9/148 , A61K31/565
摘要： Nanoparticulate compositions comprising at least one poorly soluble angiogenesis inhibitor and at least one surface stabilizer are described. The nanoparticulate compositions have an average particle size of less than about 2000 nm. The invention also describes methods of making and using such compositions.
摘要翻译： 描述包含至少一种难溶性血管发生抑制剂和至少一种表面稳定剂的纳米颗粒组合物。 纳米颗粒组合物具有小于约2000nm的平均粒度。 本发明还描述了制备和使用这些组合物的方法。
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公开(公告)号：US20100322852A1
公开(公告)日：2010-12-23
申请号：US12870722
申请日：2010-08-27
申请人： Elaine Merisko-Liversidge , H. William Bosch , Greta G. Cary , John Pruitt , Tuula Ryde , Rajeev Jain , Amy Walters
发明人： Elaine Merisko-Liversidge , H. William Bosch , Greta G. Cary , John Pruitt , Tuula Ryde , Rajeev Jain , Amy Walters
IPC分类号： A61K31/565 , A61K9/00 , A61K38/16 , A61K31/7052 , A61K49/00 , A61K36/00 , A61K36/886 , A61K36/82 , A61K36/55 , A61K35/60 , A61K35/00 , A61K39/00 , A61P9/00 , A61P35/00
CPC分类号： A61K31/00 , A61K9/145 , A61K9/146 , A61K9/148 , A61K31/565
摘要： Nanoparticulate compositions comprising at least one poorly soluble angiogenesis inhibitor and at least one surface stabilizer are described. The nanoparticulate compositions have an average particle size of less than about 2000 nm. The invention also describes methods of making and using such compositions.
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公开(公告)号：US20080220075A1
公开(公告)日：2008-09-11
申请号：US12076247
申请日：2008-03-14
申请人： Elaine Merisko-Liversidge , H. William Bosch , Greta G. Cary , John Pruitt , Tuula Ryde , Rajeev Jain , Amy Walters
发明人： Elaine Merisko-Liversidge , H. William Bosch , Greta G. Cary , John Pruitt , Tuula Ryde , Rajeev Jain , Amy Walters
CPC分类号： A61K31/565 , A61K9/145 , A61K9/146 , A61K31/00
摘要： Nanoparticulate compositions comprising at least one poorly soluble angiogenesis inhibitor and at least one surface stabilizer are described. The nanoparticulate compositions have an average particle size of less than about 2000 nm. The invention also describes methods of making and using such compositions.
摘要翻译： 描述包含至少一种难溶性血管发生抑制剂和至少一种表面稳定剂的纳米颗粒组合物。 纳米颗粒组合物具有小于约2000nm的平均粒度。 本发明还描述了制备和使用这些组合物的方法。
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公开(公告)号：US20080226732A1
公开(公告)日：2008-09-18
申请号：US11928289
申请日：2007-10-30
申请人： Elaine Merisko-Liversidge , H. William Bosch , Greta G. Cary , John Pruitt , Tuula Ryde , Rajeev Jain , Amy Walters
发明人： Elaine Merisko-Liversidge , H. William Bosch , Greta G. Cary , John Pruitt , Tuula Ryde , Rajeev Jain , Amy Walters
CPC分类号： A61K31/00 , A61K9/145 , A61K9/146 , A61K9/148 , A61K31/565
摘要： Nanoparticulate compositions comprising at least one poorly soluble angiogenesis inhibitor and at least one surface stabilizer are described. The nanoparticulate compositions have an average particle size of less than about 2000 nm. The invention also describes methods of making and using such compositions.
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公开(公告)号：US20100322853A1
公开(公告)日：2010-12-23
申请号：US12870745
申请日：2010-08-27
申请人： Elaine Merisko-Liversidge , H. William Bosch , Greta G. Cary , John Pruitt , Tuula Ryde , Rajeev Jain , Amy Walters
发明人： Elaine Merisko-Liversidge , H. William Bosch , Greta G. Cary , John Pruitt , Tuula Ryde , Rajeev Jain , Amy Walters
IPC分类号： A61K31/565 , A61K9/00 , A61K9/20 , A61K9/48 , A61K38/16 , A61K31/7052 , A61K49/00 , A61K36/00 , A61K36/886 , A61K36/82 , A61K36/55 , A61K35/60 , A61K35/00 , A61K39/00 , A61P35/00 , A61P9/00 , A61P3/04
CPC分类号： A61K31/00 , A61K9/145 , A61K9/146 , A61K9/148 , A61K31/565
摘要： Nanoparticulate compositions comprising at least one poorly soluble angiogenesis inhibitor and at least one surface stabilizer are described. The nanoparticulate compositions have an average particle size of less than about 2000 nm. The invention also describes methods of making and using such compositions.
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公开(公告)号：US20080279949A1
公开(公告)日：2008-11-13
申请号：US12117982
申请日：2008-05-09
申请人： Elaine MERISKO-LIVERSIDGE , H. William Bosch , Greta G. Cary , John Pruitt , Tuula Ryde , Rajeev Jain , Amy Walters
发明人： Elaine MERISKO-LIVERSIDGE , H. William Bosch , Greta G. Cary , John Pruitt , Tuula Ryde , Rajeev Jain , Amy Walters
CPC分类号： A61K31/00 , A61K9/145 , A61K9/146 , A61K9/148 , A61K31/565
摘要： Nanoparticulate compositions comprising at least one poorly soluble angiogenesis inhibitor and at least one surface stabilizer are described. The nanoparticulate compositions have an average particle size of less than about 2000 nm. The invention also describes methods of making and using such compositions.
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9.发明申请NANOPARTICULATE COMPOSITIONS OF MITOGEN-ACTIVATED PROTEIN (MAP) KINASE INHIBITORS 有权活化蛋白（MAP）激酶抑制剂的纳米颗粒组合物公开(公告)号：US20060193920A1
公开(公告)日：2006-08-31
申请号：US11275069
申请日：2005-12-07
申请人： H. Bosch , Greta Cary , Douglas Hovey , Rajeev Jain , Laura Kline , Elaine Merisko-Liversidge , Kevin Ostrander
发明人： H. Bosch , Greta Cary , Douglas Hovey , Rajeev Jain , Laura Kline , Elaine Merisko-Liversidge , Kevin Ostrander
IPC分类号： A61K48/00 , A61K38/17 , A61K31/66 , A61K31/525 , A61K31/522 , A61K31/385 , A61K31/557 , A61K36/82 , A61K36/886 , A61K36/328
CPC分类号： A61K38/1709 , A61K9/0075 , A61K9/146 , A61K9/2022 , A61K31/385 , A61K31/522 , A61K31/525 , A61K31/557 , A61K31/66
摘要： Nanoparticulate compositions comprising at least one poorly soluble MAP kinase inhibitor and at least one surface stabilizer are described. The nanoparticulate compositions have an average particle size of less than about 2000 nm. The invention also describes methods of making and using such compositions.
摘要翻译： 描述了包含至少一种难溶性MAP激酶抑制剂和至少一种表面稳定剂的纳米颗粒组合物。 纳米颗粒组合物具有小于约2000nm的平均粒度。 本发明还描述了制备和使用这些组合物的方法。
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公开(公告)号：US20070298115A1
公开(公告)日：2007-12-27
申请号：US11802542
申请日：2007-05-23
申请人： Tuula Ryde , Evan Gustow , Stephen Ruddy , Rajeev Jain , Rakesh Patel , Michael Wilkins
发明人： Tuula Ryde , Evan Gustow , Stephen Ruddy , Rajeev Jain , Rakesh Patel , Michael Wilkins
IPC分类号： A61K31/235 , A61K9/50 , A61P3/04 , A61P43/00 , A61P9/00 , C07C69/767 , C13K13/00
CPC分类号： A61K31/19 , A61K9/145 , A61K9/146 , A61K9/2077 , A61K31/14 , A61K31/216 , A61K45/06 , Y10T428/29 , A61K2300/00
摘要： The present invention is directed to fibrate compositions having improved pharmacokinetic profiles and reduced fed/fasted variability. The fibrate particles of the composition have an effective average particle size of less than about 2000 nm.
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