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1.发明授权Jasmonate derivative compounds, pharmaceuticals compounds and methods of use thereof 有权茉莉酸衍生物化合物，药物化合物及其使用方法公开(公告)号：US07425651B2
公开(公告)日：2008-09-16
申请号：US10581546
申请日：2004-12-01
申请人： Eliezer Flescher , Yoel Kashman , Dorit Reischer , Shiri Shimony
发明人： Eliezer Flescher , Yoel Kashman , Dorit Reischer , Shiri Shimony
IPC分类号： C07C61/00 , C07C69/74 , A61K31/215
CPC分类号： C07C69/716 , C07C2601/08
摘要： The present invention provides novel jasmonate derivative compounds, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for treatment of cancers, especially mammalian cancers.
摘要翻译： 本发明提供新颖的茉莉酸衍生物化合物，其制备方法，包括这些化合物的药物组合物，以及使用这些化合物和组合物，特别是作为治疗癌症尤其是哺乳动物癌症的化学治疗剂的方法。
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2.发明申请Jasmonate Derivative Compounds, Pharmaceuticals Compounds and Methods of Use Thereof 有权茉莉酸衍生物，药物化合物及其使用方法公开(公告)号：US20080319066A1
公开(公告)日：2008-12-25
申请号：US12198559
申请日：2008-08-26
申请人： Eliezer FLESCHER , Yoel Kashman , Dorit Reischer , Shiri Shimony
发明人： Eliezer FLESCHER , Yoel Kashman , Dorit Reischer , Shiri Shimony
IPC分类号： A61K31/215 , C07C69/66 , A61P35/00
CPC分类号： C07C69/716 , C07C2601/08
摘要： The present invention provides novel jasmonate derivative compounds, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for treatment of cancers, especially mammalian cancers.
摘要翻译： 本发明提供新颖的茉莉酸衍生物化合物，其制备方法，包括这些化合物的药物组合物，以及使用这些化合物和组合物，特别是作为治疗癌症尤其是哺乳动物癌症的化学治疗剂的方法。
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3.发明授权Jasmonate derivative compounds pharmaceutical compounds and methods of use thereof 有权茉莉酸衍生物化合物药物化合物及其使用方法公开(公告)号：US07683211B2
公开(公告)日：2010-03-23
申请号：US12198559
申请日：2008-08-26
申请人： Eliezer Flescher , Yoel Kashman , Dorit Reischer , Shiri Shimony
发明人： Eliezer Flescher , Yoel Kashman , Dorit Reischer , Shiri Shimony
IPC分类号： C07C61/00 , C07C69/74 , A61K31/215
CPC分类号： C07C69/716 , C07C2601/08
摘要： The present invention provides novel jasmonate derivative compounds, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for treatment of cancers, especially mammalian cancers.
摘要翻译： 本发明提供新颖的茉莉酸衍生物化合物，其制备方法，包括这些化合物的药物组合物，以及使用这些化合物和组合物，特别是作为治疗癌症尤其是哺乳动物癌症的化学治疗剂的方法。
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4.发明申请Jasmonate derivative compounds, pharmaceuticals compounds and methods of use thereof 有权茉莉酸衍生物化合物，药物化合物及其使用方法公开(公告)号：US20070142474A1
公开(公告)日：2007-06-21
申请号：US10581546
申请日：2004-12-01
申请人： Eliezer Flescher , Yoel Kashman , Dorit Reischer , Shiri Shimony
发明人： Eliezer Flescher , Yoel Kashman , Dorit Reischer , Shiri Shimony
IPC分类号： A61K31/557 , C07C61/06
CPC分类号： C07C69/716 , C07C2601/08
摘要： The present invention provides novel jasmonate derivative compounds, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for treatment of cancers, especially mammalian cancers.
摘要翻译： 本发明提供新颖的茉莉酸衍生物化合物，其制备方法，包括这些化合物的药物组合物，以及使用这些化合物和组合物的方法，特别是作为治疗癌症尤其是哺乳动物癌症的化学治疗剂。
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5.发明申请CHEMICAL DERIVATIVES OF JASMONATE, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开佐剂的化学衍生物，药物组合物及其使用方法公开(公告)号：US20090291904A1
公开(公告)日：2009-11-26
申请号：US12095908
申请日：2006-12-07
申请人： Yoel Kashman , Eliezer Flescher , Max Herzberg
发明人： Yoel Kashman , Eliezer Flescher , Max Herzberg
IPC分类号： A61K31/7004 , C07D215/48 , C07H15/203 , A61K31/47 , C12N5/06 , A61P35/00
CPC分类号： C07D215/32 , C07C49/493 , C07C69/007 , C07C69/716 , C07C69/738 , C07C235/78 , C07C2601/02 , C07C2601/08 , C07F7/1804 , C07H13/08
摘要： The present invention relates to novel jasmonate derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for prevention and treatment of cancers.
摘要翻译： 本发明涉及新颖的茉莉酸衍生物，其制备方法，包括这些化合物的药物组合物，以及使用这些化合物和组合物，特别是作为预防和治疗癌症的化学治疗剂的方法。
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公开(公告)号：US20110038914A1
公开(公告)日：2011-02-17
申请号：US12934704
申请日：2009-03-25
申请人： Yehuda Benayahu , Dafna Benayahu , Yoel Kashman , Amira Rudi , Yoram Lanir , Ido Sella , Einat Raz
发明人： Yehuda Benayahu , Dafna Benayahu , Yoel Kashman , Amira Rudi , Yoram Lanir , Ido Sella , Einat Raz
摘要： An isolated collagen fiber is disclosed, wherein a length of the fiber prior to stretching by about 15%, is identical to a length of the fiber following said stretching by about 15%. The fiber comprises a Nuclear Magnetic Resonance (NMR) spectroscopic profile as shown in FIG. 1. Uses thereof and method of isolating are also disclosed.
摘要翻译： 公开了一种分离的胶原纤维，其中在拉伸之前纤维的长度约15％与所述拉伸后纤维的长度相同约15％。 纤维包含如图1所示的核磁共振（NMR）光谱分布。 还公开了其用途和隔离方法。
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7.发明授权Calanolide and related antiretroviral compounds, compositions, and uses thereof 失效卡拉宁内酯和相关的抗逆转录病毒化合物，组合物及其用途
公开(公告)号：US5591770A
公开(公告)日：1997-01-07
申请号：US65618
申请日：1993-05-21
申请人： Michael R. Boyd , John H. Cardellina, II , Kirk R. Gustafson , James B. McMahon , Richard W. Fuller , Gordon M. Cragg , Yoel Kashman , Doel Soejarto
发明人： Michael R. Boyd , John H. Cardellina, II , Kirk R. Gustafson , James B. McMahon , Richard W. Fuller , Gordon M. Cragg , Yoel Kashman , Doel Soejarto
IPC分类号： A61K31/365 , A61K31/366 , A61K36/18 , A61K45/06 , A61P31/12 , A61P31/18 , C07D493/14 , C07D493/22 , A61K31/37
CPC分类号： C07D493/14 , C07D493/22
摘要： The present invention provides novel antiviral compounds, refered to as calanolides, related compounds, and their derivatives, which may be isolated from plants, or derived from compounds from plants, of the genus Calophyllum in accordance with the present inventive method. The compounds and their derivatives may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2.
摘要翻译： 根据本发明的方法，本发明提供了可以从植物中分离或衍生自Calophyllum属植物的化合物的新的抗病毒化合物，被称为calanolides，相关化合物及其衍生物。 化合物及其衍生物可以单独使用或与组合物如药物组合物中的其它抗病毒剂组合用于抑制病毒如逆转录病毒，特别是人类免疫缺陷病毒，特别是HIV-1的生长或复制 或HIV-2。
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公开(公告)号：US20100311757A1
公开(公告)日：2010-12-09
申请号：US12680405
申请日：2008-09-25
申请人： Yoel Kashman , Maurice Aknin , Amira Rudi , Ashgan Bishara , Drorit Neumann , Nathalie Ben Califa
发明人： Yoel Kashman , Maurice Aknin , Amira Rudi , Ashgan Bishara , Drorit Neumann , Nathalie Ben Califa
IPC分类号： A61K31/395 , C07D498/04 , C07D313/00 , A61K31/424 , C07D487/04 , A61K31/5025 , A61P35/00
CPC分类号： C07D313/00 , C07D487/04 , C07D498/04 , C07D498/18
摘要： Salarines and Tulearins isolated from Fascaplysinopsis sp. sponge and synthetic derivatives thereof are provided.
摘要翻译： 从Fascaplysinopsis sp。中分离出的鱼类和Tulearins。 海绵及其合成衍生物。
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公开(公告)号：US5859049A
公开(公告)日：1999-01-12
申请号：US653006
申请日：1996-05-24
申请人： Michael R. Boyd , John H. Cardellina, II , Kirk R. Gustafson , James B. McMahon , Richard W. Fuller , Gordon M. Cragg , Yoel Kashman , Doel Soejarto
发明人： Michael R. Boyd , John H. Cardellina, II , Kirk R. Gustafson , James B. McMahon , Richard W. Fuller , Gordon M. Cragg , Yoel Kashman , Doel Soejarto
IPC分类号： A61K31/365 , A61K31/366 , A61K36/18 , A61K45/06 , A61P31/12 , A61P31/18 , C07D493/14 , C07D493/22 , A61K31/37
CPC分类号： C07D493/14 , C07D493/22
摘要： The present invention provides novel antiviral compounds, refered to as calanolides, related compounds, and their derivatives, which may be isolated from plants, or derived from compounds from plants, of the genus Calophyllum in accordance with the present inventive method. The compounds and their derivatives may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2.
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10.发明授权New compounds for the study and treatment of microfilament organization in cells 失效用于研究和处理细胞中微丝组织的新化合物
公开(公告)号：US4857538A
公开(公告)日：1989-08-15
申请号：US126364
申请日：1987-11-30
申请人： Yoel Kashman , Ilan Spector , Shmuel Carmely , Dina Blasberger
发明人： Yoel Kashman , Ilan Spector , Shmuel Carmely , Dina Blasberger
IPC分类号： C07D417/04 , C07D493/08
CPC分类号： C07D417/04 , C07D493/08
摘要： A compound, and composition including same, for effecting irreversible change in cell morphology having the following structures: ##STR1## wherein R is --(CH.sub.2).sub.n ZH in which n=1, 2, 3 and 4 and Z is O, S, or NH, and ##STR2## wherein R.sub.1 and R.sub.2 can be --OH, alkyl and acyl.
摘要翻译： 包含它们的化合物及其组合物，用于实现具有以下结构的细胞形态的不可逆变化：其中R是 - （CH 2）n ZH，其中n = 1,2,3和4 Z是O，S或NH，和Latrunculin I，其中R 1和R 2可以是-OH，烷基和酰基。
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